| + |
Neutrophil_activation | up-regulates 
|
Neutrophil_degranulation |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-270582 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 2161532 |
ANCA cause normal human neutrophils to undergo an oxidative burst and degranulate. Both ANCA phenotypes (i.e., cytoplasmic-pattern ANCA and myeloperoxidase-specific ANCA) induce neutrophil activation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Tissue: |
Blood Serum |
| + |
CXCL5 | up-regulates
|
Neutrophil_activation |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-277732 |
|
|
Homo sapiens |
Neutrophil |
| pmid |
sentence |
| 34237033 |
We demonstrate that collagen-induced DDR1 activation in cancer cells is a major stimulus for CXCL5 production, resulting in the recruitment of tumor-associated neutrophils (TANs), the formation of neutrophil extracellular traps (NETs), and subsequent cancer cell invasion and metastasis. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
MPO-ANCA | up-regulates
|
Neutrophil_activation |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-270583 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 2161532 |
ANCA cause normal human neutrophils to undergo an oxidative burst and degranulate. Both ANCA phenotypes (i.e., cytoplasmic-pattern ANCA and myeloperoxidase-specific ANCA) induce neutrophil activation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Tissue: |
Blood Serum |
| + |
CXCL2 | up-regulates
|
Neutrophil_activation |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-277722 |
|
|
Homo sapiens |
Neutrophil |
| pmid |
sentence |
| 35022267 |
Chemotherapy-induced infiltration of neutrophils promotes pancreatic cancer metastasis via Gas6/AXL signalling axis. neutrophils are recruited to the metastatic liver via CXCL1 and 2 secretion by metastatic tumour cells. These neutrophils express growth arrest specific 6 (Gas6) which leads to AXL receptor activation on tumour cells enabling their regrowth.Taken together, these results show that the neutrophil attracting cytokines Cxcl1 and 2 are highly expressed in metastatic livers in response to gemcitabine withdrawal and this favours CXCR2-dependent recruitment of neutrophils at the hepatic metastatic site. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
Neutrophil_activation | up-regulates
|
GAS6 |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-277724 |
|
|
Homo sapiens |
Neutrophil |
| pmid |
sentence |
| 35022267 |
Chemotherapy-induced infiltration of neutrophils promotes pancreatic cancer metastasis via Gas6/AXL signalling axis. neutrophils are recruited to the metastatic liver via CXCL1 and 2 secretion by metastatic tumour cells. These neutrophils express growth arrest specific 6 (Gas6) which leads to AXL receptor activation on tumour cells enabling their regrowth.Taken together, these results show that the neutrophil attracting cytokines Cxcl1 and 2 are highly expressed in metastatic livers in response to gemcitabine withdrawal and this favours CXCR2-dependent recruitment of neutrophils at the hepatic metastatic site. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CXCL1 | up-regulates
|
Neutrophil_activation |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-277721 |
|
|
Homo sapiens |
Neutrophil |
| pmid |
sentence |
| 35022267 |
Chemotherapy-induced infiltration of neutrophils promotes pancreatic cancer metastasis via Gas6/AXL signalling axis. neutrophils are recruited to the metastatic liver via CXCL1 and 2 secretion by metastatic tumour cells. These neutrophils express growth arrest specific 6 (Gas6) which leads to AXL receptor activation on tumour cells enabling their regrowth.Taken together, these results show that the neutrophil attracting cytokines Cxcl1 and 2 are highly expressed in metastatic livers in response to gemcitabine withdrawal and this favours CXCR2-dependent recruitment of neutrophils at the hepatic metastatic site. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
Pr3-ANCA | up-regulates
|
Neutrophil_activation |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-270584 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 2161532 |
ANCA cause normal human neutrophils to undergo an oxidative burst and degranulate. Both ANCA phenotypes (i.e., cytoplasmic-pattern ANCA and myeloperoxidase-specific ANCA) induce neutrophil activation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Tissue: |
Blood Serum |
4.0
Neutrophil_activation