| + |
SNAI1 | up-regulates 
|
Metastasis |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-278098 |
|
|
Homo sapiens |
Hep-G2 Cell |
| pmid |
sentence |
| 27239445 |
We also observed that SNAI1 expression was correlated with distal metastasis, incomplete tumor capsule formation, and histological differentiation in hepatocellular carcinoma (HCC). |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
PTTG1 | up-regulates activity
|
Metastasis |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-256535 |
|
|
Mus musculus |
MCF-7 Cell |
| pmid |
sentence |
| 22002306 |
Overexpressed hPTTG1 promotes breast cancer cell invasion and metastasis by regulating GEF-H1/RhoA signalling |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
EZR | up-regulates
|
Metastasis |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-259375 |
|
|
Homo sapiens |
Rhabdomyosarcoma Cell |
| pmid |
sentence |
| 16488997 |
Ezrin is indispensable for Six1-induced metastasis and highly expressed in a panel of representative pediatric cancers. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
MET | up-regulates
|
Metastasis |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-263658 |
|
|
Homo sapiens |
Prostate Cancer Cell Line |
| pmid |
sentence |
| 22035268 |
C-Met expression and activation appears to be one of the common mechanisms of resistance to other targeted therapies. Given these multiple roles of c-Met in prostate cancer, several c-Met inhibitors have been developed. Evidence to date suggests that aberrant activation of the HGF/c-Met axis in prostate cancer epithelial cells appears to be a relatively late event in tumor progression. C-Met expression increases in advanced stages of the disease, with the highest expression observed in bone metastases. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Prostate Cancer |
| + |
PDIA6 | up-regulates activity
|
Metastasis |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-256533 |
|
|
Mus musculus |
Mammary Gland Tumor Cell Line |
| pmid |
sentence |
| 17420453 |
Overexpression of ERp5 promotes both in vitro migration and invasion and in vivo metastasis of breast cancer cells. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
CCL5 | up-regulates
|
Metastasis |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-277729 |
|
|
Homo sapiens |
Pancreatic Cancer Cell |
| pmid |
sentence |
| 38339310 |
This suggests CCL5 not only remodels the PDAC TME to benefit tumor cells, but can also enhance the tumor cell’s metastatic potential. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SPRY4 | down-regulates 
|
Metastasis |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-278110 |
|
|
Homo sapiens |
NCI-H157 Cell |
| pmid |
sentence |
| 20501643 |
The reduction of cell mobility and invasion demonstrated with Spry4 expression suggests that Spry4 may act on downstream targets to inhibit metastasis. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
BACH1 | up-regulates
|
Metastasis |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-259337 |
|
|
Homo sapiens |
Breast Cancer Cell |
| pmid |
sentence |
| 22875853 |
Transcriptional network analysis identifies BACH1 as a master regulator of breast cancer bone metastasis |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
AXL | up-regulates
|
Metastasis |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-277725 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 35022267 |
Gas6 and its main receptor AXL are overexpressed in pancreatic cancer and their expression correlates with poor prognosis.Gas6/AXL signalling in cancer cells is associated with tumour cell proliferation, epithelial mesenchymal transition and metastases. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CXCL5 | up-regulates
|
Metastasis |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-277733 |
|
|
Homo sapiens |
Pancreatic Cancer Cell |
| pmid |
sentence |
| 34237033 |
We demonstrate that collagen-induced DDR1 activation in cancer cells is a major stimulus for CXCL5 production, resulting in the recruitment of tumor-associated neutrophils (TANs), the formation of neutrophil extracellular traps (NETs), and subsequent cancer cell invasion and metastasis. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
WASF3 | up-regulates activity
|
Metastasis |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-259078 |
|
|
Chlorocebus aethiops |
|
| pmid |
sentence |
| 17623672 |
We have also shown that Abl targets and phosphorylates four tyrosine residues in WAVE3 and that the Abl-dependent phosphorylation of WAVE3 is critical for the stimulation of lamellipodia formation and cell migration. |
|
| Publications: |
1 |
Organism: |
Chlorocebus Aethiops |
| + |
CTNNB1 | up-regulates activity
|
Metastasis |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-256534 |
|
|
Mus musculus |
Mammary Gland Tumor Cell Line |
| pmid |
sentence |
| 17420453 |
Overexpression of ERp5 promotes both in vitro migration and invasion and in vivo metastasis of breast cancer cells. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
GNAI1 | down-regulates 
|
Metastasis |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-278878 |
|
|
Homo sapiens |
SNU-387 Cell |
| pmid |
sentence |
| 23691483 |
GNAI1 can signifi cantly inhibit the migration and metastasis of HCC cells. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CRABP2 | up-regulates
|
Metastasis |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-259371 |
|
|
Homo sapiens |
Lung Cancer Cell |
| pmid |
sentence |
| 30696915 |
Analysis of clinical samples revealed that high CRABP2 levels were correlated with lymph node metastases, poor overall survival, and increased recurrence. Knockdown of Crabp2 decreased migration, invasion, anoikis resistance, and in vivo metastasis. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
NFE2L2 | up-regulates
|
Metastasis |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-259285 |
|
|
Homo sapiens |
Hep-G2 Cell |
| pmid |
sentence |
| 26194347 |
Nrf2 was up-regulated in HCC, and expression of Nrf2 was correlated with tumor differentiation, metastasis, and tumor size. Further studies demonstrated that inhibition of Nrf2 expression inhibited proliferation by inducing apoptosis and repressed invasion, and up-regulation of Nrf2 expression resulted in opposite phenotypes. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
Metastasis