Relation Results

Summary

Name Metastasis
Primary ID SIGNOR-PH107
Type phenotype
Description When a cancer spreads to a different body part from where it started
Relations 15
Pathways GPCR_CRC, GPCR_HCC, iCAF signaling in PDAC, Chemokines PDAC, Prostate Cancer

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Type: Score: Layout: SPV 
0.70.70.70.70.70.70.70.70.70.70.70.70.70.70.7SPRY4MetastasisPDIA6WASF3NFE2L2CTNNB1BACH1SNAI1CRABP2PTTG1GNAI1AXLCXCL5EZRMETCCL5

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Relations
Regulator
Mechanism
target
score ℹ
+ SPRY4down-regulates img/indirect_inhibition.png Metastasis 0.7
Identifier Residue Sequence Organism Cell Line
SIGNOR-278110 Homo sapiens NCI-H157 Cell
pmid sentence
The reduction of cell mobility and invasion demonstrated with Spry4 expression suggests that Spry4 may act on downstream targets to inhibit metastasis.
Publications: 1 Organism: Homo Sapiens
+ PDIA6up-regulates activity img/indirect-activation.png Metastasis 0.7
Identifier Residue Sequence Organism Cell Line
SIGNOR-256533 Mus musculus Mammary Gland Tumor Cell Line
pmid sentence
Overexpression of ERp5 promotes both in vitro migration and invasion and in vivo metastasis of breast cancer cells.
Publications: 1 Organism: Mus Musculus
+ WASF3up-regulates activity img/indirect-activation.png Metastasis 0.7
Identifier Residue Sequence Organism Cell Line
SIGNOR-259078 Chlorocebus aethiops
pmid sentence
We have also shown that Abl targets and phosphorylates four tyrosine residues in WAVE3 and that the Abl-dependent phosphorylation of WAVE3 is critical for the stimulation of lamellipodia formation and cell migration.
Publications: 1 Organism: Chlorocebus Aethiops
+ NFE2L2up-regulates img/indirect-activation.png Metastasis 0.7
Identifier Residue Sequence Organism Cell Line
SIGNOR-259285 Homo sapiens Hep-G2 Cell
pmid sentence
Nrf2 was up-regulated in HCC, and expression of Nrf2 was correlated with tumor differentiation, metastasis, and tumor size. Further studies demonstrated that inhibition of Nrf2 expression inhibited proliferation by inducing apoptosis and repressed invasion, and up-regulation of Nrf2 expression resulted in opposite phenotypes.
Publications: 1 Organism: Homo Sapiens
+ CTNNB1up-regulates activity img/indirect-activation.png Metastasis 0.7
Identifier Residue Sequence Organism Cell Line
SIGNOR-256534 Mus musculus Mammary Gland Tumor Cell Line
pmid sentence
Overexpression of ERp5 promotes both in vitro migration and invasion and in vivo metastasis of breast cancer cells.
Publications: 1 Organism: Mus Musculus
+ BACH1up-regulates img/indirect-activation.png Metastasis 0.7
Identifier Residue Sequence Organism Cell Line
SIGNOR-259337 Homo sapiens Breast Cancer Cell
pmid sentence
Transcriptional network analysis identifies BACH1 as a master regulator of breast cancer bone metastasis
Publications: 1 Organism: Homo Sapiens
+ SNAI1up-regulates img/indirect-activation.png Metastasis 0.7
Identifier Residue Sequence Organism Cell Line
SIGNOR-278098 Homo sapiens Hep-G2 Cell
pmid sentence
We also observed that SNAI1 expression was correlated with distal metastasis, incomplete tumor capsule formation, and histological differentiation in hepatocellular carcinoma (HCC).
Publications: 1 Organism: Homo Sapiens
+ CRABP2up-regulates img/indirect-activation.png Metastasis 0.7
Identifier Residue Sequence Organism Cell Line
SIGNOR-259371 Homo sapiens Lung Cancer Cell
pmid sentence
Analysis of clinical samples revealed that high CRABP2 levels were correlated with lymph node metastases, poor overall survival, and increased recurrence. Knockdown of Crabp2 decreased migration, invasion, anoikis resistance, and in vivo metastasis.
Publications: 1 Organism: Homo Sapiens
+ PTTG1up-regulates activity img/indirect-activation.png Metastasis 0.7
Identifier Residue Sequence Organism Cell Line
SIGNOR-256535 Mus musculus MCF-7 Cell
pmid sentence
Overexpressed hPTTG1 promotes breast cancer cell invasion and metastasis by regulating GEF-H1/RhoA signalling
Publications: 1 Organism: Mus Musculus
+ GNAI1down-regulates img/direct_inhibition.png Metastasis 0.7
Identifier Residue Sequence Organism Cell Line
SIGNOR-278878 Homo sapiens SNU-387 Cell
pmid sentence
GNAI1 can signifi cantly inhibit the migration and metastasis of HCC cells.
Publications: 1 Organism: Homo Sapiens
+ AXLup-regulates img/indirect-activation.png Metastasis 0.7
Identifier Residue Sequence Organism Cell Line
SIGNOR-277725 Homo sapiens
pmid sentence
Gas6 and its main receptor AXL are overexpressed in pancreatic cancer and their expression correlates with poor prognosis.Gas6/AXL signalling in cancer cells is associated with tumour cell proliferation, epithelial mesenchymal transition and metastases.
Publications: 1 Organism: Homo Sapiens
+ CXCL5up-regulates img/indirect-activation.png Metastasis 0.7
Identifier Residue Sequence Organism Cell Line
SIGNOR-277733 Homo sapiens Pancreatic Cancer Cell
pmid sentence
 We demonstrate that collagen-induced DDR1 activation in cancer cells is a major stimulus for CXCL5 production, resulting in the recruitment of tumor-associated neutrophils (TANs), the formation of neutrophil extracellular traps (NETs), and subsequent cancer cell invasion and metastasis.
Publications: 1 Organism: Homo Sapiens
+ EZRup-regulates img/indirect-activation.png Metastasis 0.7
Identifier Residue Sequence Organism Cell Line
SIGNOR-259375 Homo sapiens Rhabdomyosarcoma Cell
pmid sentence
Ezrin is indispensable for Six1-induced metastasis and highly expressed in a panel of representative pediatric cancers.
Publications: 1 Organism: Homo Sapiens
+ METup-regulates img/indirect-activation.png Metastasis 0.7
Identifier Residue Sequence Organism Cell Line
SIGNOR-263658 Homo sapiens Prostate Cancer Cell Line
pmid sentence
C-Met expression and activation appears to be one of the common mechanisms of resistance to other targeted therapies. Given these multiple roles of c-Met in prostate cancer, several c-Met inhibitors have been developed. Evidence to date suggests that aberrant activation of the HGF/c-Met axis in prostate cancer epithelial cells appears to be a relatively late event in tumor progression. C-Met expression increases in advanced stages of the disease, with the highest expression observed in bone metastases.
Publications: 1 Organism: Homo Sapiens
Pathways:Prostate Cancer
+ CCL5up-regulates img/indirect-activation.png Metastasis 0.7
Identifier Residue Sequence Organism Cell Line
SIGNOR-277729 Homo sapiens Pancreatic Cancer Cell
pmid sentence
This suggests CCL5 not only remodels the PDAC TME to benefit tumor cells, but can also enhance the tumor cell’s metastatic potential.
Publications: 1 Organism: Homo Sapiens
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