| + |
CDK5 | up-regulates 
phosphorylation
|
HTT |
0.467 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-156836 |
Ser1179 |
LTNPPSLsPIRRKGK |
Homo sapiens |
Neuron |
| pmid |
sentence |
| 17611284 |
Huntingtin is an antiapoptotic proteinwe show here that huntingtin is phosphorylated by the cyclin-dependent kinase 5 (cdk5) at serines 1181 and 1201. Phosphorylation can be induced by dna damage in vitro and in vivo. The state of huntingtin phosphorylation is a crucial regulator of neuronal cell death. Absence of phosphorylation of huntingtin at serines 1181 and 1201 confers toxic properties to wild-type huntingtin in a p53-dependent manner in striatal neurons and accelerates neuronal death induced by dna damage. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-156840 |
Ser1199 |
EQASVPLsPKKGSEA |
Homo sapiens |
Neuron |
| pmid |
sentence |
| 17611284 |
Huntingtin is an antiapoptotic proteinwe show here that huntingtin is phosphorylated by the cyclin-dependent kinase 5 (cdk5) at serines 1181 and 1201. Phosphorylation can be induced by dna damage in vitro and in vivo. The state of huntingtin phosphorylation is a crucial regulator of neuronal cell death. Absence of phosphorylation of huntingtin at serines 1181 and 1201 confers toxic properties to wild-type huntingtin in a p53-dependent manner in striatal neurons and accelerates neuronal death induced by dna damage. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
TBK1 | up-regulates activity
phosphorylation
|
HTT |
0.296 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-270350 |
Ser13 |
KLMKAFEsLKSFQQQ |
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 32757223 |
Herein, we report the discovery and validation of a kinase, TANK-binding kinase 1 (TBK1), that efficiently phosphorylates full-length and N-terminal HTT fragments in vitro (at S13/S16), in cells (at S13) and in vivo. TBK1 expression in HD models (cells, primary neurons, and Caenorhabditis elegans) increases mutant HTT exon 1 phosphorylation and reduces its aggregation and cytotoxicity. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
AKT |
phosphorylation
|
HTT |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-89696 |
Ser419 |
GGRSRSGsIVELIAG |
Homo sapiens |
Neuron |
| pmid |
sentence |
| 12062094 |
We demonstrate that huntingtin is a substrate of akt and that phosphorylation of huntingtin by akt is crucial to mediate the neuroprotective effects of igf-1. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SGK1 | down-regulates 
phosphorylation
|
HTT |
0.386 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-121349 |
Ser419 |
GGRSRSGsIVELIAG |
Homo sapiens |
|
| pmid |
sentence |
| 14725621 |
The serum- and glucocorticoid-induced kinase sgk inhibits mutant huntingtin-induced toxicity by phosphorylating serine 421 of huntingtin. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
AKT1 |
phosphorylation
|
HTT |
0.575 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252590 |
Ser419 |
GGRSRSGsIVELIAG |
Homo sapiens |
Neuron |
| pmid |
sentence |
| 12062094 |
We demonstrate that huntingtin is a substrate of akt and that phosphorylation of huntingtin by akt is crucial to mediate the neuroprotective effects of igf-1. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
HTT
- 
- 