+ |
MAFA | up-regulates quantity by expression
transcriptional regulation
|
GLP1R |
0.338 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-254563 |
|
|
Homo sapiens |
|
pmid |
sentence |
17149590 |
the expression of important beta cell genes, e.g. those encoding solute carrier family 2 (facilitated glucose transporter), member 2 (formerly known as GLUT2), pancreatic and duodenal homeobox factor 1 (PDX1), NK6 transcription factor-related, locus 1 (NKX6-1), glucagon-like peptide 1 receptor (GLP1R), prohormone convertase 1/3 (PCSK1) and pyruvate carboxylase (PC), was regulated positively by MAFA and negatively by DN-MAFA. |
|
Publications: |
1 |
Organism: |
Homo Sapiens |
+ |
GCG | up-regulates
binding
|
GLP1R |
0.778 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-34855 |
|
|
Homo sapiens |
B-lymphocyte |
pmid |
sentence |
7937318 |
In the present study we stably expressed the rat b-cell glp-i receptor in cho cells and studied binding characteristics and receptor activation utilizing the naturally occurring receptor agonist glp-i(7-36)-amide (glp-i), the proglucagon-derived glp-i-related peptide oxyntomodulin, the glp-i receptor agonist exendin-4, and the specific antagonist exendin |
|
Publications: |
1 |
Organism: |
Homo Sapiens |
+ |
GCG | up-regulates activity
binding
|
GLP1R |
0.778 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-278133 |
|
|
Homo sapiens |
Pancreatic Beta Cell |
pmid |
sentence |
35065096 |
GLP-1 and GIP exert their physiological actions via stimulation of the two G protein-coupled receptors (GPCRs): the GLP-1 receptor (GLP-1R) and the GIP receptor (GIPR), respectively. |
|
Publications: |
1 |
Organism: |
Homo Sapiens |
+ |
GLP1R | up-regulates activity
binding
|
GNAS |
0.467 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-278137 |
|
|
Homo sapiens |
Pancreatic Beta Cell |
pmid |
sentence |
35065096 |
The GPCRs are allocated in five families where the GLP-1R and GIPR are found within the secretin family, also classified as class B [31,32]. Upon stimulation by an extracellular stimuli (ligand), GPCRs undergo conformational changes, and triggers downstream intracellular signals by coupling with G proteins (or other intracellular proteins such as arrestins), causing a wide range of both physiological and pathological processes.To stimulate insulin secretion, and in the presence of elevated blood glucose concentrations, GLP-1R activation in pancreatic beta cells promote recruitment and activation of Gαs protein leading to adenylate cyclase-mediated cAMP production, elevation of Ca2+, and ERK1/2 phosphorylation (Fig. 3) |
|
Publications: |
1 |
Organism: |
Homo Sapiens |