| + |
PDHX | down-regulates quantity by repression 
transcriptional regulation
|
GCG |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254901 |
|
|
Homo sapiens |
Glucagonoma Cell |
| pmid |
sentence |
| 12783165 |
In glucagonoma cells transduced with a Pdx1-encoding lentiviral vector, insulin gene expression was induced while glucagon mRNA levels were reduced by 50 to 60%. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
GCG | up-regulates 
binding
|
GLP1R |
0.775 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-34855 |
|
|
Homo sapiens |
B-lymphocyte |
| pmid |
sentence |
| 7937318 |
In the present study we stably expressed the rat b-cell glp-i receptor in cho cells and studied binding characteristics and receptor activation utilizing the naturally occurring receptor agonist glp-i(7-36)-amide (glp-i), the proglucagon-derived glp-i-related peptide oxyntomodulin, the glp-i receptor agonist exendin-4, and the specific antagonist exendin |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
GCG | up-regulates 
|
LATS1 |
0.276 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-199202 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 23075495 |
On the other hand, galfas-coupled signals, such as epinephrine and glucagon, induce kinase activity of lats1/2, leading to phosphorylation and yap/taz. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CDX2/PAX6/P300 | up-regulates quantity by expression
transcriptional regulation
|
GCG |
0.453 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-70957 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 10506141 |
Pax-6 and cdx-2 also directly interacted with one another at the protein level. pax-6, bound to its dna recognition site in the glucagon g1 promoter element, tethered cdx-2 to the molecular complex of pax-6 and p300. Further, we found that the presence of cdx-2 enhanced the interaction of pax-6 with p300, thus establishing a molecular complex of transcription factors implicated in tissue-specific glucagon gene expression with the basal transcriptional machinery. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
GCG | up-regulates
binding
|
GCGR |
0.769 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-198504 |
|
|
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 22863277 |
In contrast, stimulation of gs-coupled receptors by glucagon or epinephrine activates lats1/2 kinase activity, thereby inhibiting yap function. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-97338 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 12529935 |
Mutation of a highly conserved d64 residue in the n-terminal portion of the rat glucagon receptor completely eliminates glucagon binding. This residue corresponds to a mutated asp residue at amino acid 60 in the growth hormone releasing hormone receptor that gives rise to the little mouse phenotype (lin et al.1993). Antisera directed against amino acid sequences 126_137 of the n-terminal region, and agai residues 206_219 of the first extracellular loop block [125i]-glucagon binding and interfere with glucagon-induced adenylyl cyclase generation in rat liver membranes. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
GCG | up-regulates
|
LATS1/2 |
0.276 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-269857 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 23075495 |
On the other hand, galfas-coupled signals, such as epinephrine and glucagon, induce kinase activity of lats1/2, leading to phosphorylation and yap/taz. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
PAX6 | up-regulates quantity by expression
transcriptional regulation
|
GCG |
0.596 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254905 |
|
|
Homo sapiens |
BHK-21 Cell |
| pmid |
sentence |
| 12783165 |
In the heterologous cell line BHK-21, Pdx1 inhibited by 60 to 80% the activation of the alpha-cell specific element G1 conferred by Pax-6 and/or Cdx-2/3. Although Pdx1 could bind three AT-rich motifs within G1, two of which are binding sites for Pax-6 and Cdx-2/3, the affinity of Pdx1 for G1 was much lower as compared to Pax-6. In addition, Pdx1 inhibited Pax-6 mediated activation through G3, to which Pdx1 was unable to bind. Moreover, a mutation impairing DNA binding of Pdx1 had no effect on its inhibition on Cdx-2/3. Since Pdx1 interacts directly with Pax-6 and Cdx-2/3 forming heterodimers, we suggest that Pdx1 inhibits glucagon gene transcription through protein to protein interactions with Pax-6 and Cdx-2/3. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
GCG | up-regulates
|
LATS2 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-199205 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 23075495 |
On the other hand, galfas-coupled signals, such as epinephrine and glucagon, induce kinase activity of lats1/2, leading to phosphorylation and yap/taz. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
GCG
- 
- 