3.0
Summary
| Name |  GRIA4View Modifications |
| Full Name | Glutamate receptor 4 |
| Synonyms | GluR-4, GluR4, AMPA-selective glutamate receptor 4, GluR-D, Glutamate receptor ionotropic, AMPA 4, GluA4 | GLUR4 |
| Primary ID | P48058 |
| Links |  -  -  |
| Type | protein |
| Relations | 12 |
| Function | Receptor for glutamate that functions as ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. In the presence of CACNG4 or CACNG7 or CACNG8, shows resensitization which is characterized by a delayed accumulation of current flux upon continued application of glutamate. |
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Modifications Tables
Relations
| Regulator | Mechanism | target | score ℹ | |
|---|---|---|---|---|
| + | PRKCA | up-regulates 
phosphorylation
|
GRIA4 | 0.551 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | CAMK2A | up-regulates
phosphorylation
|
GRIA4 | 0.574 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | PRKACA | up-regulates
phosphorylation
|
GRIA4 | 0.415 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | PRKCG | up-regulates
phosphorylation
|
GRIA4 | 0.691 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | CAMK2G |
phosphorylation
|
GRIA4 | 0.507 |
| Publications: | 1 | |||
| + | PRKCA |
phosphorylation
|
GRIA4 | 0.551 |
| Publications: | 1 | Organism: | In Vitro | |
| + | FUS | down-regulates quantity by repression 
post transcriptional regulation
|
GRIA4 | 0.2 |
| Publications: | 1 | Organism: | Mus Musculus | |
| Tissue: | Spinal Cord | |||
| + | SHANK3 | up-regulates quantity
binding
|
GRIA4 | 0.2 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | glutamic acid | up-regulates activity
chemical activation
|
GRIA4 | 0.8 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | IQSEC2 | up-regulates quantity
relocalization
|
GRIA4 | 0.2 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| Tissue: | Brain | |||
| + | GRIA4 | up-regulates 
|
Excitatory_synaptic_transmission | 0.7 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | GRIA4 | up-regulates quantity
relocalization
|
calcium(2+) | 0.8 |
| Publications: | 1 | Organism: | Homo Sapiens | |