| + |
9-cis-retinoic acid | up-regulates activity 
chemical activation
|
RXRG |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-259239 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 18321241 |
Alitretinoin (9-cis-retinoic acid) is a unique panagonist retinoid, capable of binding to all six known retinoid receptors (RAR-alpha, -beta, -gamma, and RXR-alpha, -beta, -gamma). |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
RXRG | up-regulates quantity 
transcriptional regulation
|
MBP |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-269266 |
|
|
|
|
| pmid |
sentence |
| 31390799 |
RXRγ gene silencing reduces the ability of the drugs to promote MBP expression. |
|
| Publications: |
1 |
| + |
bexarotene | up-regulates activity
chemical activation
|
RXRG |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-259232 |
|
|
Homo sapiens |
Non-small Cell Lung Cancer Cell |
| pmid |
sentence |
| 17483357 |
Bexarotene (LGD1069, Targretin), a selective retinoid X receptor agonist, prevents and reverses gemcitabine resistance in NSCLC cells by modulating gene amplification. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
RARA | up-regulates quantity by expression
transcriptional regulation
|
RXRG |
0.653 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-16469 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 1310351 |
Here we report that the transcriptional activity of rar and rxr can be reciprocally modulated by direct interactions between the two proteins |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
RXRG | up-regulates quantity
transcriptional regulation
|
GLI2 |
0.262 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-269267 |
|
|
|
|
| pmid |
sentence |
| 31390799 |
Despite RXRγ being heavily down-regulated upon silencing (average silencing was about 80%), the reduction in Gli2 expression levels was statistically significant only for Clobetasol-treated but not for Gefitinib-treated cells. |
|
| Publications: |
1 |
| + |
all-trans-retinoic acid | up-regulates activity
chemical activation
|
RXRG |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-256193 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 17132853 |
The physiological effects of retinoic acids (RAs) are mediated by members of two families of nuclear receptors, the retinoic acid receptors (RARs) and the retinoid X receptors (RXRs), which are encoded by three distinct human genes, RXRalpha, RXRbeta, and RXRgamma. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
RARA | up-regulates
binding
|
RXRG |
0.653 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-16466 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 1310351 |
Here we report that the transcriptional activity of rar and rxr can be reciprocally modulated by direct interactions between the two proteins |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
RXRG
- 
- 