Relation Results

Summary

Name RXRG
Full Name Retinoic acid receptor RXR-gamma
Synonyms Nuclear receptor subfamily 2 group B member 3, Retinoid X receptor gamma | NR2B3
Primary ID P48443
Links - -
Type protein
Relations 7
Function Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or ...
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Type: Score: Layout: SPV 
0.80.20.2590.80.6650.89-cis-retinoic acidRXRGMBPGLI2all-trans-retinoic acidRARAbexarotene

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Relations
Regulator
Mechanism
target
score ℹ
+ 9-cis-retinoic acidup-regulates activity img/direct-activation.png chemical activation RXRG 0.8
Identifier Residue Sequence Organism Cell Line
SIGNOR-259239 Homo sapiens
pmid sentence
Alitretinoin (9-cis-retinoic acid) is a unique panagonist retinoid, capable of binding to all six known retinoid receptors (RAR-alpha, -beta, -gamma, and RXR-alpha, -beta, -gamma).
Publications: 1 Organism: Homo Sapiens
+ RXRGup-regulates quantity img/indirect-activation.png transcriptional regulation MBP 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-269266
pmid sentence
RXRγ gene silencing reduces the ability of the drugs to promote MBP expression.
Publications: 1
+ RXRGup-regulates quantity img/indirect-activation.png transcriptional regulation GLI2 0.259
Identifier Residue Sequence Organism Cell Line
SIGNOR-269267
pmid sentence
Despite RXRγ being heavily down-regulated upon silencing (average silencing was about 80%), the reduction in Gli2 expression levels was statistically significant only for Clobetasol-treated but not for Gefitinib-treated cells.
Publications: 1
+ all-trans-retinoic acidup-regulates activity img/direct-activation.png chemical activation RXRG 0.8
Identifier Residue Sequence Organism Cell Line
SIGNOR-256193 Homo sapiens
pmid sentence
The physiological effects of retinoic acids (RAs) are mediated by members of two families of nuclear receptors, the retinoic acid receptors (RARs) and the retinoid X receptors (RXRs), which are encoded by three distinct human genes, RXRalpha, RXRbeta, and RXRgamma.
Publications: 1 Organism: Homo Sapiens
+ RARAup-regulates img/direct-activation.png binding RXRG 0.665
Identifier Residue Sequence Organism Cell Line
SIGNOR-16466 Homo sapiens
pmid sentence
Here we report that the transcriptional activity of rar and rxr can be reciprocally modulated by direct interactions between the two proteins
Publications: 1 Organism: Homo Sapiens
+ RARAup-regulates quantity by expression img/indirect-activation.png transcriptional regulation RXRG 0.665
Identifier Residue Sequence Organism Cell Line
SIGNOR-16469 Homo sapiens
pmid sentence
Here we report that the transcriptional activity of rar and rxr can be reciprocally modulated by direct interactions between the two proteins
Publications: 1 Organism: Homo Sapiens
+ bexaroteneup-regulates activity img/direct-activation.png chemical activation RXRG 0.8
Identifier Residue Sequence Organism Cell Line
SIGNOR-259232 Homo sapiens Non-small Cell Lung Cancer Cell
pmid sentence
Bexarotene (LGD1069, Targretin), a selective retinoid X receptor agonist, prevents and reverses gemcitabine resistance in NSCLC cells by modulating gene amplification.
Publications: 1 Organism: Homo Sapiens
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