4.0
Summary
| Name |  MBPView Modifications |
| Full Name | Myelin basic protein |
| Synonyms | MBP, Myelin A1 protein, Myelin membrane encephalitogenic protein |
| Primary ID | P02686 |
| Links |  -  -  |
| Type | protein |
| Relations | 26 |
| Function | The classic group of MBP isoforms (isoform 4-isoform 14) are with PLP the most abundant protein components of the myelin membrane in the CNS. They have a role in both its formation and stabilization. The smaller isoforms might have an important role in remyelination of denuded axons in multiple sclerosis. The non-classic group of MBP isoforms (isoform 1-isoform 3/Golli-MBPs) may preferentially have a role in the early developing brain long before myelination, maybe as components of transcriptional complexes, and may also be involved in signaling pathways in T-cells and neural cells. Differential splicing events combined with optional post-translational modifications give a wide spectrum of isomers, with each of them potentially having a specialized function. Induces T-cell proliferation. |
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Modifications Tables
Relations
| Regulator | Mechanism | target | score ℹ |
|---|---|
| + | PRKACA |