| + |
TP53 | up-regulates quantity by expression 
transcriptional regulation
|
FNTB |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-242353 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 26469958 |
In this study, we provided evidence that p53 induces the expression of a group of enzymes of the MVA pathway including 3'-hydroxy-3'-methylglutaryl-coenzyme A reductase, MVA kinase, farnesyl diphosphate synthase and farnesyl diphosphate farnesyl transferase 1, in the human glioblastoma multiforme cell line, U343 cells, and in normal human astrocytes, NHAs. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
FNTB | up-regulates activity 
|
HRAS |
0.472 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-242565 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 24294527 |
Major investments have been made to target Ras through indirect routes. Inhibition of farnesyl transferase to block Ras maturation has failed in large clinical trials. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
FNTB | up-regulates activity
|
MRAS |
0.276 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-242562 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 24294527 |
Major investments have been made to target Ras through indirect routes. Inhibition of farnesyl transferase to block Ras maturation has failed in large clinical trials. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
FNTB | up-regulates activity
|
KRAS |
0.428 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-242556 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 24294527 |
Major investments have been made to target Ras through indirect routes. Inhibition of farnesyl transferase to block Ras maturation has failed in large clinical trials. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
FNTB
- 
- 