Summary

Name UBE2A
Full Name Ubiquitin-conjugating enzyme E2 A
Synonyms E2 ubiquitin-conjugating enzyme A, RAD6 homolog A, HR6A, hHR6A, Ubiquitin carrier protein A, Ubiquitin-protein ligase A | RAD6A
Primary ID P49459
Links - -
Type protein
Relations 4
Function Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In association with the E3 enzyme BRE1 (RNF20 and/or RNF40), it plays a role in transcription regulation by catalyzing the monoubiquitination of histone H2B at 'Lys-120' to form H2BK120ub1. H2BK120ub1 gives a specific tag for epigenetic transcriptional activation, elongation by RNA polymerase II, telomeric silencing, and is also a prerequisite for H3K4me and H3K79me formation. In vitro catalyzes 'Lys-11', as well as 'Lys-48'-linked polyubiquitination. Required for postreplication repair of UV-damaged DNA.

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Modifications Tables

Relations

Regulator Mechanism target score
+ up-regulates img/direct-activation.png ubiquitination PCNA 0.18
Publications: 2 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation UBE2A 0.28
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation UBE2A 0.18
Publications: 1 Organism: Homo Sapiens