4.0
Summary
| Name |  UBE2AView Modifications |
| Full Name | Ubiquitin-conjugating enzyme E2 A |
| Synonyms | E2 ubiquitin-conjugating enzyme A, RAD6 homolog A, HR6A, hHR6A, Ubiquitin carrier protein A, Ubiquitin-protein ligase A | RAD6A |
| Primary ID | P49459 |
| Links |  -  -  |
| Type | protein |
| Relations | 7 |
| Function | Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In association with the E3 enzyme BRE1 (RNF20 and/or RNF40), it plays a role in transcription regulation by catalyzing the monoubiquitination of histone H2B at 'Lys-120' to form H2BK120ub1. H2BK120ub1 gives a specific tag for epigenetic transcriptional activation, elongation by RNA polymerase II, telomeric silencing, and is also a prerequisite for H3K4me and H3K79me formation. In vitro catalyzes 'Lys-11', as well as 'Lys-48'-linked polyubiquitination. Required for postreplication repair of UV-damaged DNA. |
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Modifications Tables
Relations
| Regulator | Mechanism | target | score ℹ | |
|---|---|---|---|---|
| + | UBE2A | up-regulates 
ubiquitination
|
PCNA | 0.475 |
| Publications: | 2 | Organism: | Homo Sapiens | |
| + | CDK9 | up-regulates activity
phosphorylation
|
UBE2A | 0.449 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | CDK1 | up-regulates
phosphorylation
|
UBE2A | 0.368 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | CDK2 | up-regulates
phosphorylation
|
UBE2A | 0.372 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | Ub:E1 (UBA6 substrate) | up-regulates activity
ubiquitination
|
UBE2A | 0.675 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | Ub:E1 (UBA1 substrate) | up-regulates activity
ubiquitination
|
UBE2A | 0.788 |
| Publications: | 1 | Organism: | Homo Sapiens | |