| + |
PPM1F | down-regulates activity 
dephosphorylation
|
CHEK1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-276987 |
Ser317 |
ENVKYSSsQPEPRTG |
Homo sapiens |
|
| pmid |
sentence |
| 31944151 |
As a result, inactivation of Chk1 by POPX2 leads to impaired G1S checkpoint activation and cells are able to proceed from G1 to S phase despite DNA damage.|We also determined that POPX2 can dephosphorylate Chk1Ser317 and -Ser345 and is a potential regulator of Chk1 function in the cell. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-276988 |
Ser345 |
LVQGISFsQPTCPDH |
Homo sapiens |
|
| pmid |
sentence |
| 31944151 |
As a result, inactivation of Chk1 by POPX2 leads to impaired G1S checkpoint activation and cells are able to proceed from G1 to S phase despite DNA damage.|We also determined that POPX2 can dephosphorylate Chk1Ser317 and -Ser345 and is a potential regulator of Chk1 function in the cell. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
PPM1F | down-regulates activity
dephosphorylation
|
PAK1 |
0.399 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-248530 |
Ser57 |
KKDRFYRsILPGDKT |
Rattus norvegicus |
|
| pmid |
sentence |
| 11864573 |
The p21-activated kinase PAK is negatively regulated by POPX1 and POPX2, a pair of serine/threonine phosphatases of the PP2C family|POPX Can Dephosphorylate and Downregulate PAK| To confirm that POPX2 acts on αPAK phospho-Thr422, a key regulator of activity in the kinase activation loop [9], we used phospho-specific antibodies against αPAK P-Thr422 (Figure 3B, lower panel), which proved to be an excellent substrate for POPX2. Similarly, complete loss of αPAK P-Ser57 with 0.2 μg POPX2 contrasts with the slight loss observed with 1.5 μg PP1. On the basis of these results, we suggest PAK is a substrate of POPX. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-248531 |
Thr423 |
PEQSKRStMVGTPYW |
Rattus norvegicus |
|
| pmid |
sentence |
| 11864573 |
The p21-activated kinase PAK is negatively regulated by POPX1 and POPX2, a pair of serine/threonine phosphatases of the PP2C family|POPX Can Dephosphorylate and Downregulate PAK| To confirm that POPX2 acts on αPAK phospho-Thr422, a key regulator of activity in the kinase activation loop [9], we used phospho-specific antibodies against αPAK P-Thr422 (Figure 3B, lower panel), which proved to be an excellent substrate for POPX2. Similarly, complete loss of αPAK P-Ser57 with 0.2 μg POPX2 contrasts with the slight loss observed with 1.5 μg PP1. On the basis of these results, we suggest PAK is a substrate of POPX. |
|
| Publications: |
2 |
Organism: |
Rattus Norvegicus |
| + |
PPM1F | down-regulates activity
dephosphorylation
|
LATS1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-276989 |
Thr1079 |
EHAFYEFtFRRFFDD |
Homo sapiens |
|
| pmid |
sentence |
| 30863499 |
POPX2 is capable of dephosphorylating LATS1 at Thr1079 (Figure xref ), which is a residue critical for LATS1 activity.|POPX2 might negatively regulate the activities of MST1 and LATS1 through dephosphorylation.|We found that POPX2 could dephosphorylate LATS1 on Threonine-1079, leading to inactivation of LATS1 kinase. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
PPM1F | down-regulates
dephosphorylation
|
CAMK2A |
0.337 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-124309 |
Thr286 |
SCMHRQEtVDCLKKF |
Homo sapiens |
Neuron |
| pmid |
sentence |
| 15140879 |
Ppm1f specifically dephosphorylates the phospho-thr-286 in autophosphorylated camkii substrate and thus deactivates the camkii in vitro. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
PPM1F | down-regulates
dephosphorylation
|
PAK2 |
0.264 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-162149 |
|
|
Homo sapiens |
Breast Cancer Cell, MCF-7 Cell |
| pmid |
sentence |
| 20016286 |
Pop x2, a pp 2c serine/threonine phosphatase, is known to dephosphorylate pak and downregulate its activity. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
PPM1F | down-regulates activity
dephosphorylation
|
MAP3K7 |
0.405 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-277047 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 28906490 |
However, our current work shows that POPX2 can downregulate TAK1 and affect the anti-apoptotic activities of TAK1, implying that silencing POPX2 could facilitate TAK1 activation and will lead to increased cell survival.|We have also demonstrated that POPX2 can directly dephosphorylate TAK1 (XREF_FIG). |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
PPM1F | down-regulates
dephosphorylation
|
PAK |
0.399 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-269882 |
|
|
Homo sapiens |
Breast Cancer Cell, MCF-7 Cell |
| pmid |
sentence |
| 20016286 |
Pop x2, a pp 2c serine/threonine phosphatase, is known to dephosphorylate pak and downregulate its activity. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
PPM1F | down-regulates
dephosphorylation
|
PAK1 |
0.399 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-162146 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 20016286 |
Pop x2, a pp 2c serine/threonine phosphatase, is known to dephosphorylate pak and downregulate its activity. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
PPM1F | down-regulates activity
dephosphorylation
|
CAMK4 |
0.355 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-277157 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 11726284 |
Calmodulin-dependent protein kinase phosphatase (CaMKP) dephosphorylates and concomitantly deactivates multifunctional Ca(2+)/calmodulin-dependent protein kinases , such as CaMKI, CaMKII, and CaMKIV. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
PPM1F | down-regulates activity
dephosphorylation
|
CAMK1 |
0.475 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-277111 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 11726284 |
Calmodulin-dependent protein kinase phosphatase (CaMKP) dephosphorylates and concomitantly deactivates multifunctional Ca(2+)/calmodulin-dependent protein kinases , such as CaMKI, CaMKII, and CaMKIV. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
PPM1F
- 
- 