Summary

Name NUP153
Full Name Nuclear pore complex protein Nup153
Synonyms 153 kDa nucleoporin, Nucleoporin Nup153
Primary ID P49790
Links - -
Type protein
Relations 9
Function Component of the nuclear pore complex (NPC), a complex required for the trafficking across the nuclear envelope. Functions as a scaffolding element in the nuclear phase of the NPC essential for normal nucleocytoplasmic transport of proteins and mRNAs. Involved in the quality control and retention of unspliced mRNAs in the nucleus; in association with TPR, regulates the nuclear export of unspliced mRNA species bearing constitutive transport element (CTE) in a NXF1- and KHDRBS1-independent manner. Mediates TPR anchoring to the nuclear membrane at NPC. The repeat-containing domain may be involved in anchoring other components of the NPC to the pore membrane. Possible DNA-binding subunit of the nuclear pore complex (NPC).

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▶Modifications Tables

Relations

Regulator Mechanism target score ℹ
+ MAPK3 img/unknown.png phosphorylation NUP153 0.4
Publications: 2 Organism: Homo Sapiens
+ MAPK1 img/unknown.png phosphorylation NUP153 0.397
Publications: 2 Organism: Homo Sapiens
+ SUN1up-regulates activity img/direct-activation.png binding NUP153 0.443
Publications: 1 Organism: Homo Sapiens
+ ERK1/2 img/unknown.png phosphorylation NUP153 0.2
Publications: 1 Organism: Homo Sapiens
+ NUP153form complex img/form-complex.png binding NPC 0.731
Publications: 1
+ Gbeta img/unknown.png phosphorylation NUP153 0.2
Publications: 1 Organism: Homo Sapiens
+ TNPO1up-regulates activity img/direct-activation.png relocalization NUP153 0.514
Publications: 1