| + |
AKT | down-regulates 
phosphorylation
|
CDKN1C |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-201042 |
Ser282 |
FFAKRKRsAPEKSSG |
Homo sapiens |
Breast Cancer Cell |
| pmid |
sentence |
| 23421998 |
Cdk inhibitor p57 (kip2) is downregulated by akt during her2-mediated tumorigenicityakt phosphorylates p57 on ser 282 or thr310. Akt activity results in destabilization of p57 by accelerating turnover rate of p57 and enhancing p57 ubiquitination |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-201046 |
Thr310 |
GVGSVEQtPRKRLR |
Homo sapiens |
Breast Cancer Cell |
| pmid |
sentence |
| 23421998 |
Cdk inhibitor p57 (kip2) is downregulated by akt during her2-mediated tumorigenicityakt phosphorylates p57 on ser 282 or thr310. Akt activity results in destabilization of p57 by accelerating turnover rate of p57 and enhancing p57 ubiquitination |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
AKT1 | down-regulates
phosphorylation
|
CDKN1C |
0.459 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252535 |
Ser282 |
FFAKRKRsAPEKSSG |
Homo sapiens |
Breast Cancer Cell |
| pmid |
sentence |
| 23421998 |
Cdk inhibitor p57 (kip2) is downregulated by akt during her2-mediated tumorigenicityakt phosphorylates p57 on ser 282 or thr310. Akt activity results in destabilization of p57 by accelerating turnover rate of p57 and enhancing p57 ubiquitination |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252536 |
Thr310 |
GVGSVEQtPRKRLR |
Homo sapiens |
Breast Cancer Cell |
| pmid |
sentence |
| 23421998 |
Cdk inhibitor p57 (kip2) is downregulated by akt during her2-mediated tumorigenicityakt phosphorylates p57 on ser 282 or thr310. Akt activity results in destabilization of p57 by accelerating turnover rate of p57 and enhancing p57 ubiquitination |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
VHL | up-regulates quantity by expression 
transcriptional regulation
|
CDKN1C |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255601 |
|
|
Homo sapiens |
Renal Cell Carcinoma Cell |
| pmid |
sentence |
| 15824735 |
three of the nine targets had been identified previously as candidate TSGs (DOC-2/DAB2, CDKN1C and SPARC) and all were upregulated by wild-type pVHL. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
HLX | up-regulates quantity by expression 
transcriptional regulation
|
CDKN1C |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-261620 |
|
|
Homo sapiens |
SGHPL-4 Cell |
| pmid |
sentence |
| 20008130 |
In this study, we have identified cell cycle regulatory genes as downstream targets of the homeobox gene HLX in cultured trophoblast cells, namely RB1, MYC, EGR1, CDKN1C, ELK1, CCNB1, and JUN. RB1 and MYC mRNA expression was increased with HLX inactivation, whereas EGR1, CDKN1C, ELK1, CCNB1, and JUN mRNA expression was decreased compared with mock-transfected control cells. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
MAPK14 | up-regulates
phosphorylation
|
CDKN1C |
0.265 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-198390 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 22820251 |
G1-s control by p38/hog1 sapks upon osmostress. Upon osmostress, activated p38 and hog1 sapks phosphorylate the s/cdk inhibitor p57 or sic1 respectively at one single residue. In mammalian cells (left panel), p57 phosphorylation on thr143 leads to an increase of the affinity of p57 towards the cyclin a/cdk2 complex leading to a g1 arrest. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
CDKN1C
- 
- 