| + |
RPS6K | up-regulates activity 
phosphorylation
|
ETV1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252768 |
Ser191 |
HRFRRQLsEPCNSFP |
Homo sapiens |
|
| pmid |
sentence |
| 12213813 |
Here we describe that the 90-kDa ribosomal S6 kinase 1 (RSK1), a protein kinase downstream of the extracellular signal-regulated kinase (ERK) subclass of MAPKs, binds to ER81, phosphorylates it, and enhances ER81-dependent transcription. Two in vivo RSK1 phosphorylation sites within ER81, Ser(191) and Ser(216), were identified, whose mutation to alanine reduces ER81 activity upon ERK-MAPK stimulation. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252769 |
Ser216 |
PMYQRQMsEPNIPFP |
Homo sapiens |
|
| pmid |
sentence |
| 12213813 |
Here we describe that the 90-kDa ribosomal S6 kinase 1 (RSK1), a protein kinase downstream of the extracellular signal-regulated kinase (ERK) subclass of MAPKs, binds to ER81, phosphorylates it, and enhances ER81-dependent transcription. Two in vivo RSK1 phosphorylation sites within ER81, Ser(191) and Ser(216), were identified, whose mutation to alanine reduces ER81 activity upon ERK-MAPK stimulation. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
MAPKAPK2 | down-regulates activity 
phosphorylation
|
ETV1 |
0.595 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-250145 |
Ser191 |
HRFRRQLsEPCNSFP |
Neovison vison |
|
| pmid |
sentence |
| 11551945 |
MK2 phosphorylates ER81 in vitro within its central inhibitory domain, and overexpression of MK2 leads to increased in vivo phosphorylation of ER81. Two serine residues, ER81 amino acids 191 and 216, were identified as MK2 phosphorylation sites. MK2 suppresses basal ER81-dependent transcription |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-250146 |
Ser216 |
PMYQRQMsEPNIPFP |
Neovison vison |
|
| pmid |
sentence |
| 11551945 |
MK2 phosphorylates ER81 in vitro within its central inhibitory domain, and overexpression of MK2 leads to increased in vivo phosphorylation of ER81. Two serine residues, ER81 amino acids 191 and 216, were identified as MK2 phosphorylation sites. MK2 suppresses basal ER81-dependent transcription |
|
| Publications: |
2 |
Organism: |
Neovison Vison |
| + |
RPS6KA1 | up-regulates activity
phosphorylation
|
ETV1 |
0.356 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-249162 |
Ser191 |
HRFRRQLsEPCNSFP |
Homo sapiens |
|
| pmid |
sentence |
| 12213813 |
Here we describe that the 90-kDa ribosomal S6 kinase 1 (RSK1), a protein kinase downstream of the extracellular signal-regulated kinase (ERK) subclass of MAPKs, binds to ER81, phosphorylates it, and enhances ER81-dependent transcription. Two in vivo RSK1 phosphorylation sites within ER81, Ser(191) and Ser(216), were identified, whose mutation to alanine reduces ER81 activity upon ERK-MAPK stimulation. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-249163 |
Ser216 |
PMYQRQMsEPNIPFP |
Homo sapiens |
|
| pmid |
sentence |
| 12213813 |
Here we describe that the 90-kDa ribosomal S6 kinase 1 (RSK1), a protein kinase downstream of the extracellular signal-regulated kinase (ERK) subclass of MAPKs, binds to ER81, phosphorylates it, and enhances ER81-dependent transcription. Two in vivo RSK1 phosphorylation sites within ER81, Ser(191) and Ser(216), were identified, whose mutation to alanine reduces ER81 activity upon ERK-MAPK stimulation. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
PRKACA | up-regulates activity
phosphorylation
|
ETV1 |
0.296 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-92447 |
Ser191 |
HRFRRQLsEPCNSFP |
Homo sapiens |
|
| pmid |
sentence |
| 12213813 |
The camp-dependent protein kinase a (pka) phosphorylates er81 on ser(191)/ser(216)ser(191) and ser(216), were identified, whose mutation to alanine reduces er81 activity upon erk-mapk stimulation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
RPS6KA5 | up-regulates activity
phosphorylation
|
ETV1 |
0.476 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-262987 |
Ser216 |
PMYQRQMsEPNIPFP |
Homo sapiens |
HEK-293T Cell |
| pmid |
sentence |
| 12213813 |
Activated, overexpressed MSK1 was able to phosphorylate ER81 at Ser191 and Ser216. Mutation of these residues strongly impairs ER81-responsive promoter activity. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
PRKACA | up-regulates
phosphorylation
|
ETV1 |
0.296 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-92455 |
Ser334 |
PTYQRRGsLQLWQFL |
Homo sapiens |
|
| pmid |
sentence |
| 12213813 |
Pka targets er81 on ser(334) in vivo. Surprisingly, phosphorylation of ser(334) severely reduces the dna-binding ability of er81 but also enhances the transactivation potential of er81. These counteractive effects of pka phosphorylation on er81-dependent transcription may cause the selective up-regulation of promoters with high but not low affinity for er81. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
MAPKAPK2 | up-regulates
phosphorylation
|
ETV1 |
0.595 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-166625 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 20626350 |
Neverthless, some transcription factors, such as e47, er81, srf and creb are also phosphorylated by mk2 |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
ETV1
- 
- 