| + |
NfKb-p65/p50 | up-regulates quantity by expression 
transcriptional regulation
|
CCL11 |
0.266 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254661 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 16604092 |
Rosmarinic acid also inhibited TNF-alpha-induced phosphorylation and degradation of IkappaB-alpha, as well as nuclear translocation of NF-kappaB heterodimer induced by TNF-alpha. This suggests that rosmarinic acid downregulates the expression of CCL11 and CCR3 via the inhibition of NF-kappaB activation signaling. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CCL11 | up-regulates activity 
binding
|
CCR3 |
0.934 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-256091 |
|
|
Homo sapiens |
Eosinophil |
| pmid |
sentence |
| 10706854 |
Eotaxin and other CC chemokines acting via CC chemokine receptor-3 (CCR3) are believed to play an integral role in the development of eosinophilic inflammation in asthma and allergic inflammatory diseases. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CCL11 | up-regulates
binding
|
CCR3 |
0.934 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254356 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 24702154 |
Eotaxin (CCL11) is a specific ligand for CCR3 and serves as a potent chemoattractant for eosinophils |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
CCL11
- 
- 