| + |
CCR3 | up-regulates activity 
|
p38 |
0.251 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-256092 |
|
|
Homo sapiens |
Eosinophil |
| pmid |
sentence |
| 10706854 |
Activation of ERK2 and p38 by eotaxin is mediated through CCR3. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CCL11 | up-regulates activity
binding
|
CCR3 |
0.934 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-256091 |
|
|
Homo sapiens |
Eosinophil |
| pmid |
sentence |
| 10706854 |
Eotaxin and other CC chemokines acting via CC chemokine receptor-3 (CCR3) are believed to play an integral role in the development of eosinophilic inflammation in asthma and allergic inflammatory diseases. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CCL11 | up-regulates
binding
|
CCR3 |
0.934 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254356 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 24702154 |
Eotaxin (CCL11) is a specific ligand for CCR3 and serves as a potent chemoattractant for eosinophils |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CCL5 | up-regulates
binding
|
CCR3 |
0.76 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254370 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 10734056 |
In addition to the CCR1 receptor, RANTES activates several members of the CC subfamily of chemokine receptors including CCR3, CCR4, and CCR5 |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CCR3 | up-regulates activity
|
ERK1/2 |
0.301 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-256093 |
|
|
Homo sapiens |
Eosinophil |
| pmid |
sentence |
| 10706854 |
Activation of ERK2 and p38 by eotaxin is mediated through CCR3. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CCR3 | up-regulates 
|
p38 |
0.251 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254358 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 11591790 |
We and others have recently found that eotaxin activates extracellular signal-regulated kinase (ERK)-1/2 and p38 mitogen-activated protein (MAP) kinases in eosinophils, and that these kinases are indispensable for eosinophil chemotaxis and degranulation |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
NfKb-p65/p50 | up-regulates quantity by expression
transcriptional regulation
|
CCR3 |
0.261 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254660 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 16604092 |
Rosmarinic acid also inhibited TNF-alpha-induced phosphorylation and degradation of IkappaB-alpha, as well as nuclear translocation of NF-kappaB heterodimer induced by TNF-alpha. This suggests that rosmarinic acid downregulates the expression of CCL11 and CCR3 via the inhibition of NF-kappaB activation signaling. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CCR3 | up-regulates
|
ERK1/2 |
0.301 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254357 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 11591790 |
We and others have recently found that eotaxin activates extracellular signal-regulated kinase (ERK)-1/2 and p38 mitogen-activated protein (MAP) kinases in eosinophils, and that these kinases are indispensable for eosinophil chemotaxis and degranulation |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
CCR3
- 
- 