Summary

Name EFNA3
Full Name Ephrin-A3
Synonyms EFL-2, EHK1 ligand, EHK1-L, EPH-related receptor tyrosine kinase ligand 3, LERK-3 | EFL2, EPLG3, LERK3
Primary ID P52797
Links - -
Type protein
Relations 6
Function Cell surface GPI-bound ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling (By similarity).

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Relations

Regulator Mechanism target score
+ up-regulates img/direct-activation.png binding EPHA8 0.28
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding EPHA4 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding EPHA2 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding EPHA3 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding EPHA5 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding EPHA7 0.14
Publications: 1 Organism: Homo Sapiens