Relation Results

Summary

Name LIMK2
Full Name LIM domain kinase 2
Synonyms LIMK-2
Primary ID P53671
Links - -
Type protein
Relations 6
Function Serine/threonine-protein kinase that plays an essential role in the regulation of actin filament dynamics (PubMed:10436159, PubMed:11018042). Acts dow ...
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Type: Score: Layout: SPV 
0.2580.7560.6170.404PRKCDLIMK2CFL1ROCK1CDC42BPA

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▶Modifications Tables

Relations
Regulator
Mechanism
target
score ℹ
+ PRKCDdown-regulates img/direct_inhibition.png phosphorylation LIMK2 0.258
Identifier Residue Sequence Organism Cell Line
SIGNOR-147716 Ser283 EGTLRRRsLRRSNSI Homo sapiens
pmid sentence
Recently we have shown that limk2 shuttles between cytoplasm and nucleus in endothelial cells and that nuclear import is inhibited by protein kinase c-mediated phosphorylation of ser-283.
Identifier Residue Sequence Organism Cell Line
SIGNOR-137927 Ser283 EGTLRRRsLRRSNSI Homo sapiens
pmid sentence
Activation of pkc by phorbol ester treatment of endothelial cells stimulated limk2 phosphorylation at ser-283 and inhibited nuclear import of limk2
Publications: 2 Organism: Homo Sapiens
+ LIMK2down-regulates activity img/direct_inhibition.png phosphorylation CFL1 0.756
Identifier Residue Sequence Organism Cell Line
SIGNOR-105098 Ser3 sGVAVSDG Homo sapiens HeLa Cell
pmid sentence
We report here that limk1 and limk2 phosphorylate both cofilin and actin-depolymerizing factor (adf) specifically at ser-3 and exhibit partially distinct substrate specificity when tested using site-directed cofilin mutants as substrates
Publications: 1 Organism: Homo Sapiens
+ ROCK1up-regulates img/direct-activation.png phosphorylation LIMK2 0.617
Identifier Residue Sequence Organism Cell Line
SIGNOR-82755 Thr505 NDRKKRYtVVGNPYW Homo sapiens
pmid sentence
Specific activation of lim kinase 2 via phosphorylation of threonine 505 by rock, a rho-dependent protein kinase
Publications: 1 Organism: Homo Sapiens
+ CDC42BPAup-regulates activity img/direct-activation.png phosphorylation LIMK2 0.404
Identifier Residue Sequence Organism Cell Line
SIGNOR-107584 Thr505 NDRKKRYtVVGNPYW Chlorocebus aethiops COS Cell
pmid sentence
These results indicate that mrckalpha phosphorylates and activates lim kinases downstream of cdc42, which in turn regulates the actin cytoskeletal reorganization through the phosphorylation and inactivation of adf/cofilin.
Publications: 1 Organism: Chlorocebus Aethiops
+ ROCK1up-regulates activity img/direct-activation.png phosphorylation LIMK2 0.617
Identifier Residue Sequence Organism Cell Line
SIGNOR-249053 Thr526 NGKSYDEtVDIFSFG Chlorocebus aethiops COS-7 Cell
pmid sentence
Specific Activation of LIM kinase 2 via Phosphorylation of Threonine 505 by ROCK, a Rho-dependent Protein Kinase
Publications: 1 Organism: Chlorocebus Aethiops
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