3.0
Summary
| Name |  LIMK2View Modifications |
| Full Name | LIM domain kinase 2 |
| Synonyms | LIMK-2 |
| Primary ID | P53671 |
| Links |  -  -  |
| Type | protein |
| Relations | 13 |
| Function | Serine/threonine-protein kinase that plays an essential role in the regulation of actin filament dynamics (PubMed:10436159, PubMed:11018042). Acts downstream of several Rho family GTPase signal transduction pathways (PubMed:10436159, PubMed:11018042). Involved in astral microtubule organization and mitotic spindle orientation during early stages of mitosis by mediating phosphorylation of TPPP (PubMed:22328514). Displays serine/threonine-specific phosphorylation of myelin basic protein and histone (MBP) in vitro (PubMed:8537403). Suppresses ciliogenesis via multiple pathways; phosphorylation of CFL1, suppression of directional trafficking of ciliary vesicles to the ciliary base, and by facilitating YAP1 nuclear localization where it acts as a transcriptional corepressor of the TEAD4 target genes AURKA and PLK1 (PubMed:25849865). |
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Modifications Tables
Relations
| Regulator | Mechanism | target | score ℹ | |
|---|---|---|---|---|
| + | LIMK2 | down-regulates activity 
phosphorylation
|
SPOP | 0.2 |
| Publications: | 3 | Organism: | Homo Sapiens | |
| + | LIMK2 | down-regulates activity
phosphorylation
|
NKX3-1 | 0.2 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | PRKCD | down-regulates
phosphorylation
|
LIMK2 | 0.256 |
| Publications: | 2 | Organism: | Homo Sapiens | |
| + | LIMK2 | down-regulates activity
phosphorylation
|
CFL1 | 0.765 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | ROCK1 | up-regulates 
phosphorylation
|
LIMK2 | 0.632 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | CDC42BPA | up-regulates activity
phosphorylation
|
LIMK2 | 0.396 |
| Publications: | 1 | Organism: | Chlorocebus Aethiops | |
| + | ROCK1 | up-regulates activity
phosphorylation
|
LIMK2 | 0.632 |
| Publications: | 1 | Organism: | Chlorocebus Aethiops | |
| + | LIMK2 | up-regulates activity
phosphorylation
|
SRPK1 | 0.2 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | LIMK2 | up-regulates quantity
phosphorylation
|
TWIST1 | 0.2 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | LIMK2 | down-regulates activity
phosphorylation
|
PTEN | 0.274 |
| Publications: | 1 | Organism: | Homo Sapiens | |