Summary

Name LIMK2
Full Name LIM domain kinase 2
Synonyms LIMK-2
Primary ID P53671
Links - -
Type protein
Relations 10
Function Serine/threonine-protein kinase that plays an essential role in the regulation of actin filament dynamics (PubMed:10436159, PubMed:11018042). Acts downstream of several Rho family GTPase signal transduction pathways (PubMed:10436159, PubMed:11018042). Involved in astral microtubule organization and mitotic spindle orientation during early stages of mitosis by mediating phosphorylation of TPPP (PubMed:22328514). Displays serine/threonine-specific phosphorylation of myelin basic protein and histone (MBP) in vitro (PubMed:8537403). Suppresses ciliogenesis via multiple pathways; phosphorylation of CFL1, suppression of directional trafficking of ciliary vesicles to the ciliary base, and by facilitating YAP1 nuclear localization where it acts as a transcriptional corepressor of the TEAD4 target genes AURKA and PLK1 (PubMed:25849865).

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▶Modifications Tables

Relations

Regulator Mechanism target score ℹ
+ LIMK2down-regulates activity img/direct_inhibition.png phosphorylation SPOP 0.2
Publications: 3 Organism: Homo Sapiens
+ PRKCDdown-regulates img/direct_inhibition.png phosphorylation LIMK2 0.256
Publications: 2 Organism: Homo Sapiens
+ LIMK2down-regulates activity img/direct_inhibition.png phosphorylation CFL1 0.766
Publications: 1 Organism: Homo Sapiens
+ CDC42BPAup-regulates activity img/direct-activation.png phosphorylation LIMK2 0.396
Publications: 1 Organism: Chlorocebus Aethiops
+ ROCK1up-regulates img/direct-activation.png phosphorylation LIMK2 0.63
Publications: 1 Organism: Homo Sapiens
+ ROCK1up-regulates activity img/direct-activation.png phosphorylation LIMK2 0.63
Publications: 1 Organism: Chlorocebus Aethiops
+ LIMK2down-regulates activity img/direct_inhibition.png phosphorylation PTEN 0.275
Publications: 1 Organism: Homo Sapiens