3.0
Summary
| Name |  WDR5View Modifications |
| Full Name | WD repeat-containing protein 5 |
| Synonyms | BMP2-induced 3-kb gene protein | BIG3 |
| Primary ID | P61964 |
| Links |  -  -  |
| Type | protein |
| Relations | 4 |
| Function | Contributes to histone modification (PubMed:19131338, PubMed:19556245, PubMed:19103755, PubMed:20018852, PubMed:16600877, PubMed:16829960). May position the N-terminus of histone H3 for efficient trimethylation at 'Lys-4' (PubMed:16829960). As part of the MLL1/MLL complex it is involved in methylation and dimethylation at 'Lys-4' of histone H3 (PubMed:19556245). H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation (PubMed:18840606). As part of the NSL complex it may be involved in acetylation of nucleosomal histone H4 on several lysine residues (PubMed:19103755, PubMed:20018852). May regulate osteoblasts differentiation (By similarity). In association with RBBP5 and ASH2L, stimulates the histone methyltransferase activities of KMT2A, KMT2B, KMT2C, KMT2D, SETD1A and SETD1B (PubMed:21220120, PubMed:22266653). |
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Modifications Tables
Relations
| Regulator | Mechanism | target | score ℹ | |
|---|---|---|---|---|
| + | PASK | up-regulates activity 
phosphorylation
|
WDR5 | 0.309 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | WDR5 | form complex 
binding
|
Set1-Ash2 HMT complex | 0.917 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | WDR5 | form complex
binding
|
HMT | 0.891 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | WDR5 | form complex
binding
|
NSL histone acetyltransferase | 0.654 |
| Publications: | 1 | Organism: | Homo Sapiens | |