Summary

Name WDR5
Full Name WD repeat-containing protein 5
Synonyms BMP2-induced 3-kb gene protein | BIG3
Primary ID P61964
Links - -
Type protein
Relations 3
Function Contributes to histone modification (PubMed:19131338, PubMed:19556245, PubMed:19103755, PubMed:20018852, PubMed:16600877, PubMed:16829960). May position the N-terminus of histone H3 for efficient trimethylation at 'Lys-4' (PubMed:16829960). As part of the MLL1/MLL complex it is involved in methylation and dimethylation at 'Lys-4' of histone H3 (PubMed:19556245). H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation (PubMed:18840606). As part of the NSL complex it may be involved in acetylation of nucleosomal histone H4 on several lysine residues (PubMed:19103755, PubMed:20018852). May regulate osteoblasts differentiation (By similarity). In association with RBBP5 and ASH2L, stimulates the histone methyltransferase activities of KMT2A, KMT2B, KMT2C, KMT2D, SETD1A and SETD1B (PubMed:21220120, PubMed:22266653).

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Relations

Regulator Mechanism target score ℹ
+ WDR5form complex img/form-complex.png binding Set1-Ash2 HMT complex 0.916
Publications: 1 Organism: Homo Sapiens
+ WDR5form complex img/form-complex.png binding HMT 0.889
Publications: 1 Organism: Homo Sapiens
+ WDR5form complex img/form-complex.png binding NSL histone acetyltransferase 0.648
Publications: 1 Organism: Homo Sapiens