Summary

Name RAB1A
Full Name Ras-related protein Rab-1A
Synonyms YPT1-related protein | RAB1
Primary ID P62820
Links - -
Type protein
Relations 8
Function The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. RAB1A regulates vesicular protein transport from the endoplasmic reticulum (ER) to the Golgi compartment and on to the cell surface, and plays a role in IL-8 and growth hormone secretion. Regulates the level of CASR present at the cell membrane. Plays a role in cell adhesion and cell migration, via its role in protein trafficking. Plays a role in autophagosome assembly and cellular defense reactions against pathogenic bacteria. Plays a role in microtubule-dependent protein transport by early endosomes and in anterograde melanosome transport.

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Relations

Regulator Mechanism target score ℹ
+ RAB1Aup-regulates activity img/direct-activation.png binding C9orf72 0.492
Publications: 1 Organism: Homo Sapiens
+ RAB1Aup-regulates activity img/direct-activation.png binding mTORC1 0.323
Publications: 1 Organism: Homo Sapiens
+ RAB1Aup-regulates activity img/direct-activation.png binding USO1 0.79
Publications: 1 Organism: In Vitro
+ RAB1Aup-regulates activity img/direct-activation.png relocalization ULK1 0.552
Publications: 1 Organism: Homo Sapiens
+ RAB1Aup-regulates activity img/direct-activation.png binding ULK1/Atg13/Fip200 0.385
Publications: 1 Organism: Homo Sapiens
+ RAB1Aup-regulates activity img/direct-activation.png relocalization GOLGA2 0.706
Publications: 1 Organism: Rattus Norvegicus
+ CDK1down-regulates activity img/direct_inhibition.png phosphorylation RAB1A 0.504
Publications: 1 Organism: Homo Sapiens
+ C9orf72up-regulates activity img/direct-activation.png binding RAB1A 0.492
Publications: 1 Organism: Homo Sapiens