4.0
Summary
| Name |  RAB1AView Modifications |
| Full Name | Ras-related protein Rab-1A |
| Synonyms | YPT1-related protein | RAB1 |
| Primary ID | P62820 |
| Links |  -  -  |
| Type | protein |
| Relations | 11 |
| Function | The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. RAB1A regulates vesicular protein transport from the endoplasmic reticulum (ER) to the Golgi compartment and on to the cell surface, and plays a role in IL-8 and growth hormone secretion. Regulates the level of CASR present at the cell membrane. Plays a role in cell adhesion and cell migration, via its role in protein trafficking. Plays a role in autophagosome assembly and cellular defense reactions against pathogenic bacteria. Plays a role in microtubule-dependent protein transport by early endosomes and in anterograde melanosome transport. |
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Modifications Tables
Relations
| Regulator | Mechanism | target | score ℹ | |
|---|---|---|---|---|
| + | MAP3K7 | up-regulates activity 
phosphorylation
|
RAB1A | 0.2 |
| Publications: | 1 | Organism: | In Vitro | |
| + | RAB1A | up-regulates activity
relocalization
|
GOLGA2 | 0.718 |
| Publications: | 1 | Organism: | Rattus Norvegicus | |
| + | RAB1A | up-regulates activity
binding
|
ULK1/Atg13/Fip200 | 0.373 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | RAB1A | up-regulates activity
binding
|
C9orf72 | 0.474 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | RAB1A | up-regulates activity
binding
|
USO1 | 0.798 |
| Publications: | 1 | Organism: | In Vitro | |
| + | RAB1A | up-regulates activity
binding
|
mTORC1 | 0.316 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | CDK1 | down-regulates activity 
phosphorylation
|
RAB1A | 0.526 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | TRAPP III complex, TRAPPC2B variant | up-regulates activity
gtpase-activating protein
|
RAB1A | |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | TRAPP III complex, TRAPPC2 variant | up-regulates activity
gtpase-activating protein
|
RAB1A | |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | RAB1A | up-regulates activity
relocalization
|
ULK1 | 0.532 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | C9orf72 | up-regulates activity
binding
|
RAB1A | 0.474 |
| Publications: | 1 | Organism: | Homo Sapiens | |