Relation Results

Summary

Name NFKB1
Full Name Nuclear factor NF-kappa-B p105 subunit
Synonyms DNA-binding factor KBF1, EBP-1, Nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
Primary ID P19838
Links - -
Type protein
Relations 51
Pathways Glucocorticoid receptor Signaling, NOTCH Signaling
Inhibitors 2,5-dimethylcelecoxib
Function NF-kappa-B is a pleiotropic transcription factor present in almost all cell types and is the endpoint of a series of signal transduction events that a ...
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Type: Score: Layout: SPV 
0.2770.4960.3930.850.7410.2470.3820.20.20.2580.5880.3320.5760.640.7050.3010.5890.5780.40.80.3070.3060.680.20.20.550.20.5280.4030.7320.20.3570.20.510.4360.4170.5140.705CHEK1NFKB1PRKACAGSK3BIKBKBCHUKCASP8AP2NOTCH1BMP4BTF3POMCMAP3K7AKT2BCL3BIRC3RELACD80NR3C1BTRChsa-miR-146a2,5-dimethylcelecoxibCTCFTNFSF10MAP3K8NPPBTHBDTRAF1IEX-1LNFKBIERNF123NFKBIAKLK3PPARGC1APERPSCF-betaTRCPRBX1BIRC2BCL10NfKb-p65/p50

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▶Modifications Tables

Relations
Regulator
Mechanism
target
score ℹ
+ CHEK1down-regulates img/direct_inhibition.png phosphorylation NFKB1 0.277
Identifier Residue Sequence Organism Cell Line
SIGNOR-195208 Ser328 INITKPAsVFVQLRR Homo sapiens
pmid sentence
Taken together, the above findings suggest that chk1 phosphorylates p50 at s329 and further, that this phosphorylation blocks p50 dna binding.
Publications: 1 Organism: Homo Sapiens
+ PRKACAup-regulates img/direct-activation.png phosphorylation NFKB1 0.496
Identifier Residue Sequence Organism Cell Line
SIGNOR-158595 Ser337 FVQLRRKsDLETSEP Homo sapiens
pmid sentence
In this study, we demonstrate that the phosphorylation of p50 and p65 by the catalytic subunit of protein kinase a (pkac) is essential for nf-kappab dna binding and transactivation activity. treatment with h89 and knockdown of pkac in cells led to the inhibition of phosphorylation at p50 ser(337) and p65 ser(276) and loss of dna binding by nf-kappab.
Publications: 1 Organism: Homo Sapiens
+ GSK3Bup-regulates quantity by stabilization img/direct-activation.png phosphorylation NFKB1 0.393
Identifier Residue Sequence Organism Cell Line
SIGNOR-251251 Ser903 KTTSQAHsLPLSPAS Mus musculus Fibroblast
pmid sentence
GSK-3 beta forms an in vivo complex with and specifically phosphorylates NF-kappa B1/p105 at Ser-903 and Ser-907 in vitro. GSK-3 beta has a dual effect on p105: it stabilizes p105 under resting conditions and primes p105 for degradation upon tumor necrosis factor (TNF)-alpha treatment. Indeed, constitutive processing of p105 to p50 occurs at a higher rate in cells lacking GSK-3 beta with respect to wild-type cells and can be reduced upon reintroduction of GSK-3 beta by transfection. S903A and S907A point mutations impair p105 proteolysis in response to TNF-α.
Identifier Residue Sequence Organism Cell Line
SIGNOR-251252 Ser907 QAHSLPLsPASTRQQ Mus musculus Fibroblast
pmid sentence
GSK-3 beta forms an in vivo complex with and specifically phosphorylates NF-kappa B1/p105 at Ser-903 and Ser-907 in vitro. GSK-3 beta has a dual effect on p105: it stabilizes p105 under resting conditions and primes p105 for degradation upon tumor necrosis factor (TNF)-alpha treatment. Indeed, constitutive processing of p105 to p50 occurs at a higher rate in cells lacking GSK-3 beta with respect to wild-type cells and can be reduced upon reintroduction of GSK-3 beta by transfection. S903A and S907A point mutations impair p105 proteolysis in response to TNF-α.
Publications: 2 Organism: Mus Musculus
+ IKBKBdown-regulates activity img/direct_inhibition.png phosphorylation NFKB1 0.85
Identifier Residue Sequence Organism Cell Line
SIGNOR-104803 Ser923 DELRDSDsVCDSGVE Homo sapiens HEK-293 Cell
pmid sentence
Ikkbeta phosphorylates p105 resulting in its degradation, which releases tpl2 resulting in activation of the pro-proliferative map kinase- pathway.
Identifier Residue Sequence Organism Cell Line
SIGNOR-104807 Ser927 DSDSVCDsGVETSFR Homo sapiens HEK-293 Cell
pmid sentence
Ikkbeta phosphorylates p105 resulting in its degradation, which releases tpl2 resulting in activation of the pro-proliferative map kinase- pathway.
Identifier Residue Sequence Organism Cell Line
SIGNOR-104811 Ser932 CDSGVETsFRKLSFT Homo sapiens HEK-293 Cell
pmid sentence
Ikkbeta phosphorylates p105 resulting in its degradation, which releases tpl2 resulting in activation of the pro-proliferative map kinase- pathway.
Publications: 3 Organism: Homo Sapiens
+ CHUKdown-regulates quantity by destabilization img/direct_inhibition.png phosphorylation NFKB1 0.741
Identifier Residue Sequence Organism Cell Line
SIGNOR-70449 Ser923 DELRDSDsVCDSGVE Homo sapiens HeLa Cell
pmid sentence
All residues of p105 phosphorylated by ikka are c-terminal; the major phosphorylation region contains three serines (ser923; ser927;ser932) and two threonines (thr927 and thr391).
Identifier Residue Sequence Organism Cell Line
SIGNOR-235434 Ser923 DELRDSDsVCDSGVE Mus musculus NIH-3T3 Cell
pmid sentence
The i b kinase (ikk) complex rapidly phosphorylates nf- b1 p105 on serine 927 in the pest region romashkova et al. demonstrated that akt binds to and activates inhibitor of kappa b kinase-alfa (ikkalfa), which in turn phosphorylates and thereby promotes the degradation of the inhibitory cofactor of nf-kb, i-kb the scf-betatrcp complex is responsible for the ubiquitination of p100 and p105 following their phosphorylation by ikk.
Identifier Residue Sequence Organism Cell Line
SIGNOR-235438 Ser927 DSDSVCDsGVETSFR Mus musculus NIH-3T3 Cell
pmid sentence
The i b kinase (ikk) complex rapidly phosphorylates nf- b1 p105 on serine 927 in the pest region romashkova et al. demonstrated that akt binds to and activates inhibitor of kappa b kinase-alfa (ikkalfa), which in turn phosphorylates and thereby promotes the degradation of the inhibitory cofactor of nf-kb, i-kb the scf-betatrcp complex is responsible for the ubiquitination of p100 and p105 following their phosphorylation by ikk.
Identifier Residue Sequence Organism Cell Line
SIGNOR-70453 Ser927 DSDSVCDsGVETSFR Homo sapiens HeLa Cell
pmid sentence
All residues of p105 phosphorylated by ikka are c-terminal; the major phosphorylation region contains three serines (ser923; ser927;ser932) and two threonines (thr927 and thr391).
Identifier Residue Sequence Organism Cell Line
SIGNOR-235442 Ser932 CDSGVETsFRKLSFT Mus musculus NIH-3T3 Cell
pmid sentence
The i b kinase (ikk) complex rapidly phosphorylates nf- b1 p105 on serine 927 in the pest region romashkova et al. demonstrated that akt binds to and activates inhibitor of kappa b kinase-alfa (ikkalfa), which in turn phosphorylates and thereby promotes the degradation of the inhibitory cofactor of nf-kb, i-kb the scf-betatrcp complex is responsible for the ubiquitination of p100 and p105 following their phosphorylation by ikk.
Identifier Residue Sequence Organism Cell Line
SIGNOR-70457 Ser932 CDSGVETsFRKLSFT Homo sapiens HeLa Cell
pmid sentence
All residues of p105 phosphorylated by ikka are c-terminal; the major phosphorylation region contains three serines (ser923; ser927;ser932) and two threonines (thr927 and thr391).
Identifier Residue Sequence Organism Cell Line
SIGNOR-70461 Thr931 VCDSGVEtSFRKLSF Homo sapiens HeLa Cell
pmid sentence
All residues of p105 phosphorylated by ikka are c-terminal; the major phosphorylation region contains three serines (ser923; ser927;ser932) and two threonines (thr927 and thr391).
Publications: 7 Organism: Homo Sapiens, Mus Musculus
+ IKBKBdown-regulates quantity by destabilization img/direct_inhibition.png phosphorylation NFKB1 0.85
Identifier Residue Sequence Organism Cell Line
SIGNOR-70465 Ser923 DELRDSDsVCDSGVE Homo sapiens Fibrosarcoma Cell
pmid sentence
Ikkbeta phosphorylates p105 resulting in its degradation, which releases tpl2 resulting in activation of the pro-proliferative map kinase- pathway.
Identifier Residue Sequence Organism Cell Line
SIGNOR-70469 Ser927 DSDSVCDsGVETSFR Homo sapiens Fibrosarcoma Cell
pmid sentence
Ikkbeta phosphorylates p105 resulting in its degradation, which releases tpl2 resulting in activation of the pro-proliferative map kinase- pathway.
Identifier Residue Sequence Organism Cell Line
SIGNOR-70473 Ser932 CDSGVETsFRKLSFT Homo sapiens Fibrosarcoma Cell
pmid sentence
Ikkbeta phosphorylates p105 resulting in its degradation, which releases tpl2 resulting in activation of the pro-proliferative map kinase- pathway.
Publications: 3 Organism: Homo Sapiens
+ PRKACAup-regulates quantity by stabilization img/direct-activation.png phosphorylation NFKB1 0.496
Identifier Residue Sequence Organism Cell Line
SIGNOR-260327 Ser937 ETSFRKLsFTESLTS
pmid sentence
Ser940 of p105 was phosphorylated by PKA to a similar extent, whereas no phosphorylation of the same sequence occurred when Ser940 was substituted by Ala|Mechanistically, phosphorylation of p105 at Ser940 by PKA appeared to attenuate the extent of IKK-dependent phosphorylation of p105 at Ser935, which could in turn influence the rate of activation of NF-kappaB
Publications: 1
+ CASP8AP2up-regulates img/direct-activation.png binding NFKB1 0.247
Identifier Residue Sequence Organism Cell Line
SIGNOR-177104 Homo sapiens
pmid sentence
In addition, both cleavage products of c-flip turned out to be inducers of nf-kb activity by binding to the ikk complex.
Publications: 1 Organism: Homo Sapiens
+ NOTCH1up-regulates quantity by expression img/indirect-activation.png transcriptional regulation NFKB1 0.382
Identifier Residue Sequence Organism Cell Line
SIGNOR-110963 Homo sapiens B-lymphocyte
pmid sentence
Nf-kappab activity is regulated by notch-1 via transcriptional control of nf-kappab.
Publications: 1 Organism: Homo Sapiens
Pathways:NOTCH Signaling
+ NFKB1down-regulates quantity by repression img/direct_inhibition.png transcriptional regulation BMP4 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-266086 Homo sapiens A-549 Cell
pmid sentence
 The effect of TNF-alpha on the Bmp4 promoter is mediated through NF-kB.
Publications: 1 Organism: Homo Sapiens
+ BTF3down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation NFKB1 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-253950 Homo sapiens
pmid sentence
In contrast, BTF3 silencing resulted in down-regulation of several cancer-associated genes, including EPHB2, ABL2, HPSE2 and ATM, and up-regulation of KRAG, RRAS2, NFkappa-B, MRVI1, MADCAM1 and others. In conclusion, BTF3 is overexpressed in PDAC, where it acts as a transcriptional regulator rather than a direct modulator of apoptosis.
Publications: 1 Organism: Homo Sapiens
+ POMCdown-regulates activity img/indirect_inhibition.png NFKB1 0.258
Identifier Residue Sequence Organism Cell Line
SIGNOR-252371 Homo sapiens Melanoma Cell
pmid sentence
Alpha-MSH is an anti-inflammatory peptide which signals by binding to the melanocortin-1 receptor (MC1R) and elevating cyclic AMP in several different cells and tissues. The carboxyl terminal peptides of alpha-MSH (KPV/GKPV) are the smallest minimal sequences that prevent inflammation, but it is not known if they operate via MC1R or cyclic AMP. Immobilized alpha-melanocyte stimulating hormone 10-13 (GKPV) inhibits tumor necrosis factor-alpha stimulated NF-kappaB activity.
Publications: 1 Organism: Homo Sapiens
+ MAP3K7up-regulates quantity by expression img/indirect-activation.png transcriptional regulation NFKB1 0.588
Identifier Residue Sequence Organism Cell Line
SIGNOR-55713 Homo sapiens HeLa Cell
pmid sentence
These results suggest that tak1 induces nf-kappa b activation through a novel nik-independent signaling pathway.
Publications: 1 Organism: Homo Sapiens
+ AKT2up-regulates img/indirect-activation.png NFKB1 0.332
Identifier Residue Sequence Organism Cell Line
SIGNOR-156530 Homo sapiens
pmid sentence
Several studies have demonstrated that akt signaling can activate the nf-kb transcription factor downstream of a variety of stimuli, such as tumor necrosis factor (tnfalfa)
Publications: 1 Organism: Homo Sapiens
+ BCL3up-regulates activity img/direct-activation.png binding NFKB1 0.576
Identifier Residue Sequence Organism Cell Line
SIGNOR-254789 Homo sapiens Corneal Epithelial Cell
pmid sentence
In the present study, we report that regulation of CTCF by extracellular stress signals is dependent upon activations of an oxidative stress-regulated protein Bcl-3. We found that activated Bcl-3 was able to bind to the κB sites identified in the CTCF promoter region. Bcl-3 was activated by UV irradiation to interact with NF-κB p50 by forming a Bcl-3/p50 heterodimer complex. The Bcl-3/p50 complex suppressed CTCF promoter activity to down-regulate CTCF transcription.
Publications: 1 Organism: Homo Sapiens
+ NFKB1up-regulates quantity by expression img/indirect-activation.png transcriptional regulation BIRC3 0.64
Identifier Residue Sequence Organism Cell Line
SIGNOR-59951 Homo sapiens
pmid sentence
Thus, our data indicate that nf-kb controls the expression of traf1 and traf2 and c-iap1 and c-iap2
Publications: 1 Organism: Homo Sapiens
+ NFKB1up-regulates activity img/direct-activation.png binding RELA 0.705
Identifier Residue Sequence Organism Cell Line
SIGNOR-55378 Homo sapiens
pmid sentence
Here we report the crystal structure at 2.9 a resolution of the p50/p65 heterodimer bound to the kappab dna
Publications: 1 Organism: Homo Sapiens
+ NFKB1up-regulates quantity by expression img/indirect-activation.png transcriptional regulation CD80 0.301
Identifier Residue Sequence Organism Cell Line
SIGNOR-253934 Mus musculus B-lymphocyte
pmid sentence
Upon CD40 signaling, transcription of the CD80 gene is induced by the nuclear factor (NF)-kappaB transcription factor. Our results show that BCL6 prevents CD40-induced expression of CD80 by binding its promoter region in vivo and suppressing its transcriptional activation by NF-kappaB. Consistent with a physiologic role for BCL6 in suppressing CD80, the expression of these two genes is mutually exclusive in B cells, and BCL6-defective mice show increased expression of CD80 in B cells.
Publications: 1 Organism: Mus Musculus
+ NR3C1down-regulates quantity by repression img/direct_inhibition.png transcriptional regulation NFKB1 0.589
Identifier Residue Sequence Organism Cell Line
SIGNOR-251680 Homo sapiens
pmid sentence
We have described how the receptor uses several means to achieve repression of the genes regulated by AP-1 and NF-KB proteins
Publications: 1 Organism: Homo Sapiens
Pathways:Glucocorticoid receptor Signaling
+ BTRCdown-regulates quantity by destabilization img/direct_inhibition.png polyubiquitination NFKB1 0.578
Identifier Residue Sequence Organism Cell Line
SIGNOR-272570 in vitro
pmid sentence
Here we demonstrate that following IkappaB kinase (IkappaK)-mediated phosphorylation, the C-terminal domain of p105 (residues 918-934) serves as a recognition motif for the SCF(beta)(-TrCP) ubiquitin ligase.In vitro, SCF(beta)(-TrCP) specifically conjugates and promotes processing of phosphorylated p105.
Publications: 1 Organism: In Vitro
+ NFKB1up-regulates quantity by expression img/direct-activation.png post transcriptional regulation hsa-miR-146a 0.4
Identifier Residue Sequence Organism Cell Line
SIGNOR-277937 Homo sapiens MDA-MB-231 Cell
pmid sentence
These data suggest that TRAIL induces miR-146a expression in an NF-κB-dependent manner in MDA-MB-231 breast cancer cells.
Publications: 1 Organism: Homo Sapiens
+ 2,5-dimethylcelecoxibdown-regulates activity img/direct_inhibition.png chemical inhibition NFKB1 0.8
Identifier Residue Sequence Organism Cell Line
SIGNOR-278101 Homo sapiens HeLa Cell
pmid sentence
DMC inhibits EGR1 promoter activity by influencing NF-κB
Publications: 1 Organism: Homo Sapiens
+ NFKB1down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation CTCF 0.307
Identifier Residue Sequence Organism Cell Line
SIGNOR-254788 Homo sapiens
pmid sentence
In the present study, we report that regulation of CTCF by extracellular stress signals is dependent upon activations of an oxidative stress-regulated protein Bcl-3. We found that activated Bcl-3 was able to bind to the κB sites identified in the CTCF promoter region. Bcl-3 was activated by UV irradiation to interact with NF-κB p50 by forming a Bcl-3/p50 heterodimer complex. The Bcl-3/p50 complex suppressed CTCF promoter activity to down-regulate CTCF transcription.
Publications: 1 Organism: Homo Sapiens
+ TNFSF10up-regulates quantity by expression img/direct-activation.png post transcriptional regulation NFKB1 0.306
Identifier Residue Sequence Organism Cell Line
SIGNOR-277936 Homo sapiens MDA-MB-231 Cell
pmid sentence
Treatment with TRAIL increased the NF-κB transcriptional activity by approximately twofold in MDA-MB-231 cells compared to the control.
Publications: 1 Organism: Homo Sapiens
+ NFKB1down-regulates img/direct_inhibition.png binding MAP3K8 0.68
Identifier Residue Sequence Organism Cell Line
SIGNOR-196747 Homo sapiens
pmid sentence
Tpl-2 is stoichiometrically complexed with the nf-kb inhibitory protein, nf-kb1 p105, and the ubiquitin-binding protein abin-2, both of which are required to maintain tpl-2 protein stability. Binding to p105 also prevents tpl-2 from phosphorylating mek
Publications: 1 Organism: Homo Sapiens
+ NFKB1 img/unknown.png transcriptional regulation NPPB 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-253648
pmid sentence
In comparison to the ANF gene, less is known about BNP promoter consensus elements that regulate gene expression by mechanical or neurohumoral agonists. A number of cis-acting elements for GATA, Nkx2.5, NF-kappaB and TEF transcription factors have recently been identified within the BNP promoter that regulate BNP expression in response to specific agonists. This review focuses on the information available regarding cis-acting determinants responsible for inducible BNP transcription.
Publications: 1
+ NFKB1down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation THBD 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-254811 Homo sapiens
pmid sentence
Blocking the transcriptional activation of NF-kappaB prevented the TNFalpha-induced downregulation of TM.
Publications: 1 Organism: Homo Sapiens
+ NFKB1up-regulates quantity by expression img/indirect-activation.png transcriptional regulation TRAF1 0.55
Identifier Residue Sequence Organism Cell Line
SIGNOR-59954 Homo sapiens
pmid sentence
Thus, our data indicate that nf-kb controls the expression of traf1 and traf2 and c-iap1 and c-iap2
Publications: 1 Organism: Homo Sapiens
+ NFKB1up-regulates quantity by expression img/indirect-activation.png transcriptional regulation IEX-1L 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-59539 Homo sapiens
pmid sentence
Transcription factors of the nuclear factor-kappab/rel (nf-kappab) family may be important in cell survival by regulating unidentified, anti-apoptotic genes. One such gene that protects cells from apoptosis induced by fas or tumor necrosis factor type alpha (tnf), iex-1l, is described here. Its transcription induced by tnf was decreased in cells with defective nf-kappab activation, rendering them sensitive to tnf-induced apoptosis, which was abolished by transfection with iex-1l.
Publications: 1 Organism: Homo Sapiens
+ NFKBIEdown-regulates img/direct_inhibition.png binding NFKB1 0.528
Identifier Residue Sequence Organism Cell Line
SIGNOR-102774 Homo sapiens Leukemia Cell
pmid sentence
Nf-kb is normally sequestered in the cell cytoplasm by binding to ikbx, ikbb, ikbe
Publications: 1 Organism: Homo Sapiens
+ RNF123down-regulates quantity by destabilization img/direct_inhibition.png polyubiquitination NFKB1 0.403
Identifier Residue Sequence Organism Cell Line
SIGNOR-272221 Homo sapiens HEK-293 Cell
pmid sentence
 Here, we identify KPC1 as the Ub ligase (E3) that binds to the ankyrin repeats domain of p105, ubiquitinates it, and mediates its processing both under basal conditions and following signaling.
Publications: 1 Organism: Homo Sapiens
+ NFKBIAdown-regulates activity img/direct_inhibition.png binding NFKB1 0.732
Identifier Residue Sequence Organism Cell Line
SIGNOR-17688 Homo sapiens
pmid sentence
Nf-kappa b is an inducible transcription factor comprised of a 50-kd (p50) and a 65-kd (p65) subunit. Induction of nf-kappa b activity, which is a critical event in many signal transduction pathways, involves release from a cytoplasmic inhibitory protein, i kappa b, followed by translocation of the active transcription factor complex into the nucleus. we demonstrate by in vitro and in vivo methods that the recently cloned i kappa b/mad-3 interacts with both the p50 and p65 subunits of nf-kappa b
Publications: 1 Organism: Homo Sapiens
+ NFKB1up-regulates quantity by expression img/direct-activation.png transcriptional regulation KLK3 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-253668 Homo sapiens LNCaP Cell
pmid sentence
NF-kappa B activates prostate-specific antigen expression and is upregulated in androgen-independent prostate cancer.
Publications: 1 Organism: Homo Sapiens
+ PPARGC1Adown-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation NFKB1 0.357
Identifier Residue Sequence Organism Cell Line
SIGNOR-217969 Mus musculus
pmid sentence
In mouse muscles, overexpression of PGC-1beta (like PGC-1alpha) inhibited denervation atrophy, ubiquitin ligase induction, and transcription by NFkappaB
Publications: 1 Organism: Mus Musculus
Tissue: Skeletal Muscle
+ PERPdown-regulates quantity img/direct_inhibition.png ubiquitination NFKB1 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-255843 Homo sapiens
pmid sentence
We identify KPC1 as the Ub ligase (E3) that binds to the ankyrin repeats domain of p105, ubiquitinates it, and mediates its processing both under basal conditions and following signaling
Publications: 1 Organism: Homo Sapiens
+ SCF-betaTRCPup-regulates activity img/direct-activation.png ubiquitination NFKB1 0.51
Identifier Residue Sequence Organism Cell Line
SIGNOR-217190 Chlorocebus aethiops COS Cell
pmid sentence
The scf-betatrcp complex is responsible for the ubiquitination of p100 and p105 following their phosphorylation by ikk.
Publications: 1 Organism: Chlorocebus Aethiops
+ RBX1up-regulates img/direct-activation.png ubiquitination NFKB1 0.436
Identifier Residue Sequence Organism Cell Line
SIGNOR-106781 Homo sapiens
pmid sentence
The scf-betatrcp complex is responsible for the ubiquitination of p100 and p105 following their phosphorylation by ikk.
Publications: 1 Organism: Homo Sapiens
+ NFKB1up-regulates quantity by expression img/indirect-activation.png transcriptional regulation BIRC2 0.417
Identifier Residue Sequence Organism Cell Line
SIGNOR-59948 Homo sapiens
pmid sentence
Thus, our data indicate that nf-kb controls the expression of traf1 and traf2 and c-iap1 and c-iap2
Publications: 1 Organism: Homo Sapiens
+ BCL10up-regulates quantity by expression img/indirect-activation.png transcriptional regulation NFKB1 0.514
Identifier Residue Sequence Organism Cell Line
SIGNOR-274145 Homo sapiens
pmid sentence
The adaptor protein Bcl10 promotes activation of NF-κB transcription factors through paracaspase- and UBC13-dependent ubiquitination of NEMO.
Publications: 1 Organism: Homo Sapiens
+ NFKB1form complex img/form-complex.png binding NfKb-p65/p50 0.705
Identifier Residue Sequence Organism Cell Line
SIGNOR-55375 Homo sapiens
pmid sentence
Here we report the crystal structure at 2.9 a resolution of the p50/p65 heterodimer bound to the kappab dna
Publications: 1 Organism: Homo Sapiens
Pathways:Glucocorticoid receptor Signaling
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