3.0
Summary
| Name |  NFKB2View Modifications |
| Full Name | Nuclear factor NF-kappa-B p100 subunit |
| Synonyms | DNA-binding factor KBF2, H2TF1, Lymphocyte translocation chromosome 10 protein, Nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, Oncogene Lyt-10, Lyt10 | LYT10 |
| Primary ID | Q00653 |
| Links |  -  -  |
| Type | protein |
| Relations | 15 |
| Pathways | NF-KB Non Canonical |
| Function | NF-kappa-B is a pleiotropic transcription factor present in almost all cell types and is the endpoint of a series of signal transduction events that are initiated by a vast array of stimuli related to many biological processes such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52. The dimers bind at kappa-B sites in the DNA of their target genes and the individual dimers have distinct preferences for different kappa-B sites that they can bind with distinguishable affinity and specificity. Different dimer combinations act as transcriptional activators or repressors, respectively. NF-kappa-B is controlled by various mechanisms of post-translational modification and subcellular compartmentalization as well as by interactions with other cofactors or corepressors. NF-kappa-B complexes are held in the cytoplasm in an inactive state complexed with members of the NF-kappa-B inhibitor (I-kappa-B) family. In a conventional activation pathway, I-kappa-B is phosphorylated by I-kappa-B kinases (IKKs) in response to different activators, subsequently degraded thus liberating the active NF-kappa-B complex which translocates to the nucleus. In a non-canonical activation pathway, the MAP3K14-activated CHUK/IKKA homodimer phosphorylates NFKB2/p100 associated with RelB, inducing its proteolytic processing to NFKB2/p52 and the formation of NF-kappa-B RelB-p52 complexes. The NF-kappa-B heterodimeric RelB-p52 complex is a transcriptional activator. The NF-kappa-B p52-p52 homodimer is a transcriptional repressor. NFKB2 appears to have dual functions such as cytoplasmic retention of attached NF-kappa-B proteins by p100 and generation of p52 by a cotranslational processing. The proteasome-mediated process ensures the production of both p52 and p100 and preserves their independent function. p52 binds to the kappa-B consensus sequence 5'-GGRNNYYCC-3', located in the enhancer region of genes involved in immune response and acute phase reactions. p52 and p100 are respectively the minor and major form; the processing of p100 being relatively poor. Isoform p49 is a subunit of the NF-kappa-B protein complex, which stimulates the HIV enhancer in synergy with p65. In concert with RELB, regulates the circadian clock by repressing the transcriptional activator activity of the CLOCK-ARNTL/BMAL1 heterodimer. |
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Modifications Tables
Relations
| Regulator | Mechanism | target | score ℹ | |
|---|---|---|---|---|
| + | CHUK | up-regulates activity 
phosphorylation
|
NFKB2 | 0.784 |
| Publications: | 2 | Organism: | Mus Musculus | |
| Pathways: | NF-KB Non Canonical | |||
| + | MAP3K14 | up-regulates activity
phosphorylation
|
NFKB2 | 0.664 |
| Publications: | 2 | Organism: | Homo Sapiens | |
| Pathways: | NF-KB Non Canonical | |||
| + | BCL3 | up-regulates 
|
NFKB2 | 0.554 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | NOTCH1 | up-regulates quantity by expression
transcriptional regulation
|
NFKB2 | 0.293 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | RBPJ | down-regulates quantity by repression 
transcriptional regulation
|
NFKB2 | 0.27 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | Cullin 1-RBX1-Skp1 | down-regulates quantity by destabilization 
polyubiquitination
|
NFKB2 | 0.432 |
| Publications: | 1 | Organism: | Mus Musculus | |
| + | BCL3 | up-regulates
binding
|
NFKB2 | 0.554 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | TP53 | up-regulates
binding
|
NFKB2 | 0.437 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | RBX1 | up-regulates
ubiquitination
|
NFKB2 | 0.285 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | NFKB2 | up-regulates activity
binding
|
RELB | 0.749 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| Pathways: | NF-KB Non Canonical | |||
| + | FBXW7 | down-regulates quantity by destabilization
binding
|
NFKB2 | 0.404 |
| Publications: | 1 | Organism: | Mus Musculus | |
| + | SCF-betaTRCP | up-regulates activity
ubiquitination
|
NFKB2 | 0.534 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| Pathways: | NF-KB Non Canonical | |||
| + | TSC22D3 | down-regulates activity
binding
|
NFKB2 | 0.332 |
| Publications: | 1 | Organism: | Homo Sapiens | |