Relation Results

Summary

Name UBA52
Full Name Ubiquitin-60S ribosomal protein L40
Synonyms CEP52, Ubiquitin A-52 residue ribosomal protein fusion product 1 | UBCEP2
Primary ID P62987
Links - -
Type protein
Relations 8
Function [Ubiquitin]

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Type: Score: Layout: SPV 
0.380.8070.20.80.7320.20.20.607PINK1UBA5260S cytosolic large ribosomal subunitSIX4UCHL3USP7PRKNSEC23BUSP9X

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▶Modifications Tables

Relations
Regulator
Mechanism
target
score ℹ
+ PINK1up-regulates img/direct-activation.png phosphorylation UBA52 0.38
Identifier Residue Sequence Organism Cell Line
SIGNOR-270342 Ser65 DYNIQKEsTLHLVLR Mus musculus MEF Cell
pmid sentence
Here we report that ubiquitin is the genuine substrate of PINK1. PINK1 phosphorylated ubiquitin at Ser 65 both in vitro and in cells, and a Ser 65 phosphopeptide derived from endogenous ubiquitin was only detected in cells in the presence of PINK1 and following a decrease in mitochondrial membrane potential.
Publications: 1 Organism: Mus Musculus
+ UBA52form complex img/form-complex.png binding 60S cytosolic large ribosomal subunit 0.807
Identifier Residue Sequence Organism Cell Line
SIGNOR-262459 in vitro
pmid sentence
Here we report the near-atomic structure of the human ribosome derived from high-resolution single-particle cryo-electron microscopy and atomic model building. The structure has an average resolution of 3.6 Å, reaching 2.9 Å resolution in the most stable regions. |The human ribosome (80S) has a molecular weight of 4.3 MDa: the large subunit (60S) consists of 28S, 5S and 5.8S rRNAs and 47 proteins, while the small subunit (40S) possesses a single 18S rRNA chain and 33 pro- teins.
Publications: 1 Organism: In Vitro
+ SIX4up-regulates quantity by expression img/indirect-activation.png transcriptional regulation UBA52 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-62178 Homo sapiens
pmid sentence
We have demonstrated by studies of transgenic mice the importance of the mef3 motif present in the myogeninpromoter for its activation and have characterized the mef3 binding activity as consisting of two skeletal-muscle specific members of the six family, six1 and six4.
Publications: 1 Organism: Homo Sapiens
Tissue: Muscle
+ UCHL3up-regulates quantity img/direct-activation.png cleavage UBA52 0.8
Identifier Residue Sequence Organism Cell Line
SIGNOR-270827 Homo sapiens HeLa Cell
pmid sentence
Here we provide data suggesting that two of the four mammalian ubiquitin precursors, UBA52 and UBA80, are processed mostly post-translationally whereas the other two, UBB and UBC, probably undergo a combination of co- and post-translational processing. Using an unbiased biochemical approach we found that UCHL3, USP9X, USP7, USP5 and Otulin/Gumby/FAM105b are by far the most active DUBs acting on these precursors.
Publications: 1 Organism: Homo Sapiens
Pathways:Ubiquitin activation
+ USP7up-regulates quantity img/direct-activation.png cleavage UBA52 0.732
Identifier Residue Sequence Organism Cell Line
SIGNOR-270823 Homo sapiens HeLa Cell
pmid sentence
Here we provide data suggesting that two of the four mammalian ubiquitin precursors, UBA52 and UBA80, are processed mostly post-translationally whereas the other two, UBB and UBC, probably undergo a combination of co- and post-translational processing. Using an unbiased biochemical approach we found that UCHL3, USP9X, USP7, USP5 and Otulin/Gumby/FAM105b are by far the most active DUBs acting on these precursors.
Publications: 1 Organism: Homo Sapiens
Pathways:Ubiquitin activation
+ UBA52up-regulates activity img/direct-activation.png binding PRKN 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-270344 Mus musculus MEF Cell
pmid sentence
The phosphorylation-dependent interaction between ubiquitin and parkin suggests that phosphorylated ubiquitin unlocks autoinhibition of the catalytic cysteine. Our results show that PINK1-dependent phosphorylation of both parkin and ubiquitin is sufficient for full activation of parkin E3 activity. These findings demonstrate that phosphorylated ubiquitin is a parkin activator.
Publications: 1 Organism: Mus Musculus
+ SEC23B img/unknown.png binding UBA52 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-265305
pmid sentence
We validate the genotype-specific differential SEC23B–UBA52 (ribosomal protein RPL40) interaction.
Publications: 1
+ USP9Xup-regulates quantity img/direct-activation.png cleavage UBA52 0.607
Identifier Residue Sequence Organism Cell Line
SIGNOR-270825 Homo sapiens HeLa Cell
pmid sentence
Here we provide data suggesting that two of the four mammalian ubiquitin precursors, UBA52 and UBA80, are processed mostly post-translationally whereas the other two, UBB and UBC, probably undergo a combination of co- and post-translational processing. Using an unbiased biochemical approach we found that UCHL3, USP9X, USP7, USP5 and Otulin/Gumby/FAM105b are by far the most active DUBs acting on these precursors.
Publications: 1 Organism: Homo Sapiens
Pathways:Ubiquitin activation
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