| + |
USP9X | up-regulates 
deubiquitination
|
SMAD4 |
0.633 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-236855 |
Lys519 |
DYPRQSIkETPCWIE |
Mus musculus |
C2C12 Cell |
| pmid |
sentence |
| 20016939 |
Smad4 is monoubiquitinated in lysine 519 in vivo, a modification that inhibits smad4 by impeding association with phospho-smad2. Fam reverts this negative modification, re-empowering smad4 function;control of smad4 is a good way to regulate bone formation. Fam and ectodermin/tif1gamma (ecto) were reported to respectively regulate the de-ubiquitination and ubiquitination of smad4. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-195697 |
Lys519 |
DYPRQSIkETPCWIE |
Homo sapiens |
|
| pmid |
sentence |
| 22298955 |
Smad4 is monoubiquitinated in lysine 519 in vivo, a modification that inhibits smad4 by impeding association with phospho-smad2. Fam reverts this negative modification, re-empowering smad4 function;control of smad4 is a good way to regulate bone formation. Fam and ectodermin/tif1gamma (ecto) were reported to respectively regulate the de-ubiquitination and ubiquitination of smad4. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-183285 |
Lys519 |
DYPRQSIkETPCWIE |
Homo sapiens |
|
| pmid |
sentence |
| 19135894 |
Smad4 is monoubiquitinated in lysine 519 in vivo, a modification that inhibits smad4 by impeding association with phospho-smad2. Fam reverts this negative modification, re-empowering smad4 function;control of smad4 is a good way to regulate bone formation. Fam and ectodermin/tif1gamma (ecto) were reported to respectively regulate the de-ubiquitination and ubiquitination of smad4. |
|
| Publications: |
3 |
Organism: |
Mus Musculus, Homo Sapiens |
| + |
CDC14B | down-regulates quantity by destabilization 
dephosphorylation
|
USP9X |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-275613 |
Ser2547 |
YEGSEEVsPPQTKDQ |
|
|
| pmid |
sentence |
| 32152317 |
Here, we find that CDC14B antagonizes CDK1-mediated activating mitotic phosphorylation of the deubiquitinase USP9X at serine residue 2563, which we show to be essential for USP9X to mediate mitotic survival. Starting from an unbiased proteome-wide screening approach, we specify Wilms' tumor protein 1 (WT1) as the relevant substrate that becomes deubiquitylated and stabilized by serine 2563-phosphorylated USP9X in mitosis. |
|
| Publications: |
1 |
| + |
CyclinB/CDK1 | up-regulates activity
phosphorylation
|
USP9X |
0.273 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-275612 |
Ser2547 |
YEGSEEVsPPQTKDQ |
|
|
| pmid |
sentence |
| 32152317 |
Here, we find that CDC14B antagonizes CDK1-mediated activating mitotic phosphorylation of the deubiquitinase USP9X at serine residue 2563, which we show to be essential for USP9X to mediate mitotic survival. Starting from an unbiased proteome-wide screening approach, we specify Wilms' tumor protein 1 (WT1) as the relevant substrate that becomes deubiquitylated and stabilized by serine 2563-phosphorylated USP9X in mitosis. |
|
| Publications: |
1 |
| + |
CDK1 | up-regulates activity
phosphorylation
|
USP9X |
0.283 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-275608 |
Ser2547 |
YEGSEEVsPPQTKDQ |
|
|
| pmid |
sentence |
| 32152317 |
Here, we find that CDC14B antagonizes CDK1-mediated activating mitotic phosphorylation of the deubiquitinase USP9X at serine residue 2563, which we show to be essential for USP9X to mediate mitotic survival. Starting from an unbiased proteome-wide screening approach, we specify Wilms' tumor protein 1 (WT1) as the relevant substrate that becomes deubiquitylated and stabilized by serine 2563-phosphorylated USP9X in mitosis. |
|
| Publications: |
1 |
| + |
USP9X | down-regulates activity
deubiquitination
|
EPS15 |
0.275 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-245052 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 26748853 |
We identify the endocytic protein Eps15 as one of the critical substrates of USP9X |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
USP9X | up-regulates quantity
cleavage
|
RPS27A |
0.482 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-270826 |
|
|
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 26235645 |
Here we provide data suggesting that two of the four mammalian ubiquitin precursors, UBA52 and UBA80, are processed mostly post-translationally whereas the other two, UBB and UBC, probably undergo a combination of co- and post-translational processing. Using an unbiased biochemical approach we found that UCHL3, USP9X, USP7, USP5 and Otulin/Gumby/FAM105b are by far the most active DUBs acting on these precursors. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Ubiquitin activation |
| + |
USP9X | up-regulates quantity by stabilization
deubiquitination
|
SMN1 |
0.285 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253113 |
|
|
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 23112048 |
Ubiquitin-specific Protease 9x Deubiquitinates and Stabilizes the Spinal Muscular Atrophy Protein-Survival Motor Neuron |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
USP9X | up-regulates quantity
cleavage
|
Ubiquitin |
0.632 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-270831 |
|
|
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 26235645 |
Here we provide data suggesting that two of the four mammalian ubiquitin precursors, UBA52 and UBA80, are processed mostly post-translationally whereas the other two, UBB and UBC, probably undergo a combination of co- and post-translational processing. Using an unbiased biochemical approach we found that UCHL3, USP9X, USP7, USP5 and Otulin/Gumby/FAM105b are by far the most active DUBs acting on these precursors. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Ubiquitin activation |
| + |
USP9X | up-regulates quantity
cleavage
|
UBA52 |
0.593 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-270825 |
|
|
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 26235645 |
Here we provide data suggesting that two of the four mammalian ubiquitin precursors, UBA52 and UBA80, are processed mostly post-translationally whereas the other two, UBB and UBC, probably undergo a combination of co- and post-translational processing. Using an unbiased biochemical approach we found that UCHL3, USP9X, USP7, USP5 and Otulin/Gumby/FAM105b are by far the most active DUBs acting on these precursors. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Ubiquitin activation |
| + |
USP9X | up-regulates quantity by stabilization
deubiquitination
|
WT1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-275614 |
|
|
|
|
| pmid |
sentence |
| 32152317 |
Here, we find that CDC14B antagonizes CDK1-mediated activating mitotic phosphorylation of the deubiquitinase USP9X at serine residue 2563, which we show to be essential for USP9X to mediate mitotic survival. Starting from an unbiased proteome-wide screening approach, we specify Wilms' tumor protein 1 (WT1) as the relevant substrate that becomes deubiquitylated and stabilized by serine 2563-phosphorylated USP9X in mitosis. |
|
| Publications: |
1 |
3.0
USP9X
- 
- 