+ |
STAT3 | up-regulates quantity by expression
transcriptional regulation
|
HAMP |
0.439 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-255239 |
|
|
Homo sapiens |
HuH-7 Cell |
pmid |
sentence |
18671304 |
HCV-induced ROS stabilized the expression of two negative hepcidin regulators, HIF1alpha and HIF2alpha, and its expression was decreased by a HDAC inhibitor or an anti-oxidant. HCV-induced ROS also caused hypoacetylation of histones and inhibited binding of two positive regulators, C/EBPalpha and STAT3, to the hepcidin promoter, whereas anti-oxidant treatment of cells recovered C/EBPalpha and STAT3 binding to the hepcidin promoter. |
|
Publications: |
1 |
Organism: |
Homo Sapiens |
+ |
CEBPA | up-regulates quantity by expression
transcriptional regulation
|
HAMP |
0.302 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-253770 |
|
|
Homo sapiens |
HuH-7 Cell |
pmid |
sentence |
18671304 |
HCV-induced ROS stabilized the expression of two negative hepcidin regulators, HIF1alpha and HIF2alpha, and its expression was decreased by a HDAC inhibitor or an anti-oxidant. HCV-induced ROS also caused hypoacetylation of histones and inhibited binding of two positive regulators, C/EBPalpha and STAT3, to the hepcidin promoter, whereas anti-oxidant treatment of cells recovered C/EBPalpha and STAT3 binding to the hepcidin promoter. |
|
Publications: |
1 |
Organism: |
Homo Sapiens |
+ |
GATA4 | up-regulates quantity by expression
transcriptional regulation
|
HAMP |
0.2 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-254196 |
|
|
Homo sapiens |
Hep-G2 Cell |
pmid |
sentence |
21609320 |
Co-transfection of a GATA-4 expression vector with a hepcidin promoter reporter construct enhanced hepcidin promoter transcriptional activity. |
|
Publications: |
1 |
Organism: |
Homo Sapiens |