4.0
Summary
| Name |  ROR2View Modifications |
| Full Name | Tyrosine-protein kinase transmembrane receptor ROR2 |
| Synonyms | Neurotrophic tyrosine kinase, receptor-related 2 | NTRKR2 |
| Primary ID | Q01974 |
| Links |  -  -  |
| Type | protein |
| Relations | 9 |
| Function | Tyrosine-protein kinase receptor which may be involved in the early formation of the chondrocytes. It seems to be required for cartilage and growth plate development (By similarity). Phosphorylates YWHAB, leading to induction of osteogenesis and bone formation (PubMed:17717073). In contrast, has also been shown to have very little tyrosine kinase activity in vitro. May act as a receptor for wnt ligand WNT5A which may result in the inhibition of WNT3A-mediated signaling (PubMed:25029443). |
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Modifications Tables
Relations
| Regulator | Mechanism | target | score ℹ | |
|---|---|---|---|---|
| + | GSK3B/Axin/APC | down-regulates activity 
phosphorylation
|
ROR2 | 0.332 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | GSK3B | down-regulates activity
phosphorylation
|
ROR2 | 0.312 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | CSNK1E | up-regulates 
phosphorylation
|
ROR2 | 0.268 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | WNT5A | up-regulates
binding
|
ROR2 | 0.776 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | TAB1 | down-regulates
phosphorylation
|
ROR2 | 0.278 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | ROR2 | up-regulates
binding
|
ROR2 | 0.2 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | ROR2 | down-regulates activity
phosphorylation
|
VANGL2 | |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | ROR2 | up-regulates
binding
|
MAPK8 | 0.459 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | ROR2 | up-regulates
binding
|
FLNA | 0.438 |
| Publications: | 1 | Organism: | Homo Sapiens | |