Summary

Name CSNK1E
Full Name Casein kinase I isoform epsilon
Synonyms CKI-epsilon, CKIe
Primary ID P49674
Links - -
Type protein
Relations 59
Pathways Circadian clock, YAP/TAZ regulation
Inhibitors N-(2-aminoethyl)-5-chloroisoquinoline-8-sulfonamide
Function Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. Can phosphorylate a large number of proteins. Participates in Wnt signaling. Phosphorylates DVL1 and DVL2. Central component of the circadian clock. In balance with PP1, determines the circadian period length, through the regulation of the speed and rhythmicity of PER1 and PER2 phosphorylation. Controls PER1 and PER2 nuclear transport and degradation. Inhibits cytokine-induced granuloytic differentiation.

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Modifications Tables

Relations

Regulator Mechanism target score
+ up-regulates activity img/direct-activation.png phosphorylation APC 0.612
Publications: 2 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation DVL1 0.635
Publications: 2 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation LRP6 0.263
Publications: 2 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation DVL2 0.692
Publications: 2 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation CTNND1 0.289
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation DVL3 0.667
Publications: 2 Organism: In Vitro
+ down-regulates img/direct_inhibition.png phosphorylation WWTR1 0.363
Publications: 1 Organism: Homo Sapiens
Pathways:Hippo Signaling
+ down-regulates activity img/direct_inhibition.png phosphorylation CSNK1E 0.2
Publications: 8 Organism: Homo Sapiens
Pathways:Circadian clock, Hippo Signaling
+ up-regulates activity img/direct-activation.png phosphorylation TRAF3 0.308
Publications: 3 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation CSNK1E 0.263
Publications: 1 Organism: In Vitro
Pathways:Circadian clock
+ down-regulates img/direct_inhibition.png phosphorylation YAP1 0.419
Publications: 4 Organism: Homo Sapiens
Pathways:Hippo Signaling
+ down-regulates img/direct_inhibition.png phosphorylation CTNNB1 0.656
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation CTNNB1 0.656
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by destabilization img/direct_inhibition.png phosphorylation PER2 0.902
Publications: 3 Organism: In Vitro, Mus Musculus
Pathways:Circadian clock
+ down-regulates activity img/direct_inhibition.png phosphorylation PER3 0.74
Publications: 6 Organism: Chlorocebus Aethiops
Pathways:Circadian clock
+ up-regulates activity img/direct-activation.png phosphorylation BID 0.346
Publications: 2 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation CDH1 0.26
Publications: 1
Pathways:Hippo Signaling
+ down-regulates img/direct_inhibition.png phosphorylation EIF4EBP1 0.2
Publications: 2 Organism: Homo Sapiens
+ down-regulates quantity by destabilization img/direct_inhibition.png phosphorylation PER3 0.74
Publications: 1 Organism: Mus Musculus
Pathways:Circadian clock
+ up-regulates quantity img/direct-activation.png binding CSNK1E 0.2
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation PER1 0.842
Publications: 1 Organism: Homo Sapiens
Pathways:Circadian clock
+ up-regulates img/direct-activation.png phosphorylation ROR2 0.268
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity img/direct-activation.png binding CSNK1E 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation AXIN1 0.746
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation LEF1 0.268
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity img/direct-activation.png binding CSNK1E 0.331
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity img/direct-activation.png binding CSNK1E 0.256
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png chemical inhibition CSNK1E 0.8
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by destabilization img/direct_inhibition.png phosphorylation PER1 0.842
Publications: 1 Organism: Mus Musculus
Pathways:Circadian clock
+ up-regulates img/direct-activation.png binding CSNK1E 0.667
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation DVL2 0.692
Publications: 1 Organism: Caenorhabditis Elegans
+ up-regulates img/direct-activation.png phosphorylation GSK3B/Axin/APC 0.636
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation TCF3 0.2
Publications: 1 Organism: Homo Sapiens