Summary

Name CSNK1E
Full Name Casein kinase I isoform epsilon
Synonyms CKI-epsilon, CKIe
Primary ID P49674
Links - -
Type protein
Relations 51
Pathways Circadian clock
Inhibitors N-(2-aminoethyl)-5-chloroisoquinoline-8-sulfonamide
Function Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. Can phosphorylate a large number of proteins. Participates in Wnt signaling. Phosphorylates DVL1 and DVL2. Central component of the circadian clock. In balance with PP1, determines the circadian period length, through the regulation of the speed and rhythmicity of PER1 and PER2 phosphorylation. Controls PER1 and PER2 nuclear transport and degradation. Inhibits cytokine-induced granuloytic differentiation.

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Modifications Tables

Relations

Regulator Mechanism target score
+ up-regulates activity img/direct-activation.png phosphorylation APC 0.592
Publications: 2 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation DVL1 0.617
Publications: 2 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation LRP6 0.267
Publications: 2 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation DVL2 0.677
Publications: 2 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation CTNND1 0.291
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation WWTR1 0.337
Publications: 1 Organism: Homo Sapiens
Pathways:Hippo Signaling
+ down-regulates activity img/direct_inhibition.png phosphorylation CSNK1E 0.2
Publications: 8 Organism: Homo Sapiens
Pathways:Circadian clock, Hippo Signaling
+ down-regulates img/direct_inhibition.png phosphorylation YAP1 0.397
Publications: 4 Organism: Homo Sapiens
Pathways:Hippo Signaling
+ down-regulates img/direct_inhibition.png phosphorylation CTNNB1 0.641
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation CTNNB1 0.641
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation PER3 0.734
Publications: 6 Organism: Chlorocebus Aethiops
Pathways:Circadian clock
+ up-regulates activity img/direct-activation.png phosphorylation BID 0.349
Publications: 2 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation CDH1 0.263
Publications: 1
Pathways:Hippo Signaling
+ down-regulates img/direct_inhibition.png phosphorylation EIF4EBP1 0.2
Publications: 2 Organism: Homo Sapiens
+ up-regulates quantity img/direct-activation.png binding CSNK1E 0.2
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by destabilization img/direct_inhibition.png phosphorylation PER1 0.833
Publications: 1 Organism: Mus Musculus
Pathways:Circadian clock
+ up-regulates quantity img/direct-activation.png binding CSNK1E 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity img/direct-activation.png binding CSNK1E 0.338
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by destabilization img/direct_inhibition.png phosphorylation PER2 0.897
Publications: 1 Organism: Mus Musculus
Pathways:Circadian clock
+ up-regulates img/direct-activation.png phosphorylation AXIN1 0.736
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation PER1 0.833
Publications: 1 Organism: Homo Sapiens
Pathways:Circadian clock
+ up-regulates img/direct-activation.png phosphorylation TCF3 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation ROR2 0.272
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation DVL2 0.677
Publications: 1 Organism: Caenorhabditis Elegans
+ down-regulates img/direct_inhibition.png phosphorylation LEF1 0.273
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png chemical inhibition CSNK1E 0.8
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity img/direct-activation.png binding CSNK1E 0.257
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by destabilization img/direct_inhibition.png phosphorylation PER3 0.734
Publications: 1 Organism: Mus Musculus
Pathways:Circadian clock
+ up-regulates img/direct-activation.png binding CSNK1E 0.649
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation GSK3B/Axin/APC 0.621
Publications: 1 Organism: Homo Sapiens