Summary

Name CSNK1E
Full Name Casein kinase I isoform epsilon
Synonyms CKI-epsilon, CKIe
Primary ID P49674
Links - -
Type protein
Relations 44
Pathways Hippo Signaling
Inhibitors N-(2-aminoethyl)-5-chloroisoquinoline-8-sulfonamide
Function Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. Can phosphorylate a large number of proteins. Participates in Wnt signaling. Phosphorylates DVL1 and DVL2. Central component of the circadian clock. In balance with PP1, determines the circadian period length, through the regulation of the speed and rhythmicity of PER1 and PER2 phosphorylation. Controls PER1 and PER2 nuclear transport and degradation. Inhibits cytokine-induced granuloytic differentiation.

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Modifications Tables

Relations

Regulator Mechanism target score
+ up-regulates activity img/direct-activation.png phosphorylation APC 0.22
Publications: 2 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation DVL1 0.36
Publications: 2 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation LRP6 0.31
Publications: 2 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation DVL2 0.42
Publications: 2 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation CTNND1 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation WWTR1 0.22
Publications: 1 Organism: Homo Sapiens
Pathways:Hippo Signaling
+ down-regulates activity img/direct_inhibition.png phosphorylation CSNK1E 0.22
Publications: 8 Organism: Homo Sapiens
Pathways:Hippo Signaling
+ down-regulates img/direct_inhibition.png phosphorylation YAP1 0.28
Publications: 4 Organism: Homo Sapiens
Pathways:Hippo Signaling
+ down-regulates activity img/direct_inhibition.png phosphorylation CTNNB1 0.2
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation CTNNB1 0.2
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation PER3 0.14
Publications: 6 Organism: Chlorocebus Aethiops
+ up-regulates activity img/direct-activation.png phosphorylation BID 0.14
Publications: 2 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation PER2 0.49
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation EIF4EBP1 0.14
Publications: 2 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png chemical inhibition CSNK1E 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation ROR2 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation PER1 0.53
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png phosphorylation LEF1 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation GSK3B/Axin/APC 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation AXIN1 0.22
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation DVL2 0.42
Publications: 1 Organism: Caenorhabditis Elegans
+ up-regulates img/direct-activation.png binding CSNK1E 0.22
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation TCF3 0.14
Publications: 1 Organism: Homo Sapiens