| + |
BMP7 | down-regulates quantity by repression 
transcriptional regulation
|
MMP13 |
0.358 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254801 |
|
|
Homo sapiens |
Chondrocyte Cell Line |
| pmid |
sentence |
| 12734180 |
In the present study we investigated the inhibitory effects of IGF-1 and OP-1 on MMP-13 expression in human chondrocytes. We found that the suppressive effect of IGF-1 and OP-1 on the MMP-13 promoter activity was dose-dependent at the transcriptional level with a corresponding decrease in the level of MMP-13 protein. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SMAD1/4 | up-regulates quantity by expression 
transcriptional regulation
|
BMP7 |
0.562 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-248843 |
|
|
Drosophila melanogaster |
|
| pmid |
sentence |
| 19896409 |
BMPs first bind to and activate their transmembrane serine/threonine kinase receptors, which in turn phosphorylate the transcription factors Smad1/5/8 at its two C-terminal serines (SVS). Phosphorylated Smad1Cter binds to Smad4 (co-Smad) and translocates and accumulates in the nucleus, activating BMP-responsive genes (Fig. 2) [21] and [22], such as BMP4/7 and others. |
|
| Publications: |
1 |
Organism: |
Drosophila Melanogaster |
| + |
BMP7 | up-regulates quantity by expression
transcriptional regulation
|
UCP1 |
0.44 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-180354 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 18719589 |
Bmp7 activates a full program of brown adipogenesis including induction of early regulators of brown fat fate prdm16 (pr-domain-containing 16;ref. 4) and pgc-1alpha (peroxisome proliferator-activated receptor-gamma (ppargamma) coactivator-1alpha;ref. 5), increased expression of the brown-fat-defining marker uncoupling protein 1 (ucp1) and adipogenic transcription factors ppargamma and ccaat/enhancer-binding proteins (c/ebps), and induction of mitochondrial biogenesis via p38 mitogen-activated protein (map) kinase-(also known as mapk14) and pgc-1-dependent pathways |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
BMP7 | up-regulates 
binding
|
BMPR1A/1B/2 |
0.77 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-217520 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 7644468 |
In transfected cos-1 cells, osteogenic protein (op)-1/bmp-7, and less efficiently bmp-4, bound to bmpr-ii. Bmpr-ii bound ligands only weakly alone, but the binding was facilitated by the presence of previously identified type i receptors for bmps. Binding of op-1/bmp-7 to bmpr-ii was also observed in nontransfected cell lines. Moreover, a transcriptional activation signal was transduced by bmpr-ii in the presence of type i receptors after stimulation by op-1/bmp-7. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Adipogenesis |
| + |
BMP7 | up-regulates
|
MAPK14 |
0.318 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-180308 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 18719589 |
Bmp7 activates a full program of brown adipogenesis including induction of early regulators of brown fat fate prdm16 (pr-domain-containing 16;ref. 4) and pgc-1alpha (peroxisome proliferator-activated receptor-gamma (ppargamma) coactivator-1alpha;ref. 5), increased expression of the brown-fat-defining marker uncoupling protein 1 (ucp1) and adipogenic transcription factors ppargamma and ccaat/enhancer-binding proteins (c/ebps), and induction of mitochondrial biogenesis via p38 mitogen-activated protein (map) kinase-(also known as mapk14) and pgc-1-dependent pathways |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
BMP7 | up-regulates
binding
|
ACVR2A |
0.76 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-60237 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 9748228 |
We show that bmp7 and activin bind to the same type ii receptors, actrii and iib, but recruit distinct type i receptors into heteromeric receptor complexes |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
BMP7 | up-regulates
binding
|
BMPR2 |
0.797 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-30512 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 7644468 |
In transfected cos-1 cells, osteogenic protein (op)-1/bmp-7, and less efficiently bmp-4, bound to bmpr-ii. Bmpr-ii bound ligands only weakly alone, but the binding was facilitated by the presence of previously identified type i receptors for bmps. Binding of op-1/bmp-7 to bmpr-ii was also observed in nontransfected cell lines. Moreover, a transcriptional activation signal was transduced by bmpr-ii in the presence of type i receptors after stimulation by op-1/bmp-7. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
BMP7 | up-regulates activity
binding
|
BMPR1A/1B/2 |
0.77 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-232216 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 7791754 |
BMPR-II is a transmembrane serine/threonine kinase that binds BMP-2 and BMP-7 in association with multiple type I receptors, including BMPR-IA/Brk1, BMPR-IB, and ActR-I, which is also an activin type I receptor. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Adipogenesis |
| + |
NOG | down-regulates activity 
binding
|
BMP7 |
0.858 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-256484 |
|
|
in vitro |
|
| pmid |
sentence |
| 12478285 |
We report the crystal structure of the antagonist Noggin bound to BMP-7, which shows that Noggin inhibits BMP signalling by blocking the molecular interfaces of the binding epitopes for both type I and type II receptors. |
|
| Publications: |
1 |
Organism: |
In Vitro |
| + |
BMP7 | up-regulates
binding
|
ACVR1 |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-236913 |
|
|
Mus musculus |
C2C12 Cell |
| pmid |
sentence |
| 11282024 |
Bmp-4 and gdf-5 are known to bind to activin receptor-like kinase 3 (alk-3) and/or alk-6 (also termed bmp type ia and type ib receptors, respectively), whereas bmp-6 and bmp-7 preferentially bind to alk-2 |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
SOSTDC1 | down-regulates activity
|
BMP7 |
0.761 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-242752 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 18032587 |
SOSTDC1 is orthologous to a recently characterized murine antagonist of BMPs-2, -4, and -7 |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
BMP7 | up-regulates quantity by expression
transcriptional regulation
|
PRDM16 |
0.414 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-180317 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 18719589 |
Bmp7 activates a full program of brown adipogenesis including induction of early regulators of brown fat fate prdm16 (pr-domain-containing 16;ref. 4) and pgc-1alpha (peroxisome proliferator-activated receptor-gamma (ppargamma) coactivator-1alpha;ref. 5), increased expression of the brown-fat-defining marker uncoupling protein 1 (ucp1) and adipogenic transcription factors ppargamma and ccaat/enhancer-binding proteins (c/ebps), and induction of mitochondrial biogenesis via p38 mitogen-activated protein (map) kinase-(also known as mapk14) and pgc-1-dependent pathways |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
BMP7 | up-regulates
|
Brown_adipogenesis |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-180305 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 18719589 |
Here we demonstrate that whereas some members of the family of bone morphogenetic proteins (bmps) support white adipocyte differentiation, bmp7 singularly promotes differentiation of brown preadipocytes even in the absence of the normally required hormonal induction cocktail. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
BMP7 | up-regulates quantity by expression
transcriptional regulation
|
PPARGC1A |
0.294 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-180314 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 18719589 |
Bmp7 activates a full program of brown adipogenesis including induction of early regulators of brown fat fate prdm16 (pr-domain-containing 16;ref. 4) and pgc-1alpha (peroxisome proliferator-activated receptor-gamma (ppargamma) coactivator-1alpha;ref. 5), increased expression of the brown-fat-defining marker uncoupling protein 1 (ucp1) and adipogenic transcription factors ppargamma and ccaat/enhancer-binding proteins (c/ebps), and induction of mitochondrial biogenesis via p38 mitogen-activated protein (map) kinase-(also known as mapk14) and pgc-1-dependent pathways |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
BMP7 | up-regulates
transcriptional regulation
|
UCP1 |
0.44 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-210059 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 18719589 |
Bmp7 activates a full program of brown adipogenesis including induction of early regulators of brown fat fate prdm16 (pr-domain-containing 16; ref. 4) and pgc-1alpha (peroxisome proliferator-activated receptor-gamma (ppargamma) coactivator-1alpha; ref. 5), increased expression of the brown-fat-defining marker uncoupling protein 1 (ucp1) and adipogenic transcription factors ppargamma and ccaat/enhancer-binding proteins (c/ebps), and induction of mitochondrial biogenesis via p38 mitogen-activated protein (map) kinase-(also known as mapk14) and pgc-1-dependent pathways |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
BMP7 | up-regulates
binding
|
BMP7 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-236172 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 11178121 |
Bmps are dimeric proteins with a single inter-chain disulfide bond. The dimeric conformation is an absolute requirement for the biological action and interac- tion with receptors |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Tissue: |
Muscle |
| Pathways: | Adipogenesis |
| + |
BMP7 | up-regulates
binding
|
ACVR1/BMPR2 |
0.799 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-235364 |
|
|
Mus musculus |
C2C12 Cell |
| pmid |
sentence |
| 11282024 |
Bmp-4 and gdf-5 are known to bind to activin receptor-like kinase 3 (alk-3) and/or alk-6 (also termed bmp type ia and type ib receptors, respectively), whereas bmp-6 and bmp-7 preferentially bind to alk-2 |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
BMP7 | up-regulates
transcriptional regulation
|
PPARGC1A |
0.294 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-210056 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 18719589 |
Bmp7 activates a full program of brown adipogenesis including induction of early regulators of brown fat fate prdm16 (pr-domain-containing 16; ref. 4) and pgc-1alpha (peroxisome proliferator-activated receptor-gamma (ppargamma) coactivator-1alpha; ref. 5), increased expression of the brown-fat-defining marker uncoupling protein 1 (ucp1) and adipogenic transcription factors ppargamma and ccaat/enhancer-binding proteins (c/ebps), and induction of mitochondrial biogenesis via p38 mitogen-activated protein (map) kinase-(also known as mapk14) and pgc-1-dependent pathways |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
BMP7 | up-regulates
binding
|
ACTR2 |
0.294 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-144144 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 16446785 |
The two ligands induce the formation of two ligand-receptor complexes, cbmp7 (blue) and ctgf-b (red), that share the type i receptor alk2 |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
BMP7 | down-regulates quantity by repression
transcriptional regulation
|
DLK1 |
0.295 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-166426 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 20584981 |
Bmp7 could directly suppress pref-1 expression, thereby allowing the initiation of the adipogenic program. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
BMP7 | up-regulates
binding
|
ACVR2B |
0.561 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-60240 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 9748228 |
We show that bmp7 and activin bind to the same type ii receptors, actrii and iib, but recruit distinct type i receptors into heteromeric receptor complexes. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
BMP7 | up-regulates
transcriptional regulation
|
PRDM16 |
0.414 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-210053 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 18719589 |
Bmp7 activates a full program of brown adipogenesis including induction of early regulators of brown fat fate prdm16 (pr-domain-containing 16; ref. 4) and pgc-1alpha (peroxisome proliferator-activated receptor-gamma (ppargamma) coactivator-1alpha; ref. 5), increased expression of the brown-fat-defining marker uncoupling protein 1 (ucp1) and adipogenic transcription factors ppargamma and ccaat/enhancer-binding proteins (c/ebps), and induction of mitochondrial biogenesis via p38 mitogen-activated protein (map) kinase-(also known as mapk14) and pgc-1-dependent pathways |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
BMP7 | down-regulates
transcriptional regulation
|
DLK1 |
0.295 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-210074 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 20584981 |
Bmp7 could directly suppress pref-1 expression, thereby allowing the initiation of the adipogenic program. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
BMP7 | up-regulates quantity by expression
transcriptional regulation
|
PPARG |
0.328 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-180311 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 18719589 |
Bmp7 activates a full program of brown adipogenesis including induction of early regulators of brown fat fate prdm16 (pr-domain-containing 16;ref. 4) and pgc-1alpha (peroxisome proliferator-activated receptor-gamma (ppargamma) coactivator-1alpha;ref. 5), increased expression of the brown-fat-defining marker uncoupling protein 1 (ucp1) and adipogenic transcription factors ppargamma and ccaat/enhancer-binding proteins (c/ebps), and induction of mitochondrial biogenesis via p38 mitogen-activated protein (map) kinase-(also known as mapk14) and pgc-1-dependent pathways |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| Pathways: | Adipogenesis |
| + |
SOX17/POU5F1 | up-regulates quantity by expression
transcriptional regulation
|
BMP7 |
0.318 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-269260 |
|
|
|
|
| pmid |
sentence |
| 31583686 |
Both SOX2 and SOX17 are able to partner with OCT4 and, as a consequence, recognize and bind specific binding motifs.6, 7 In human and mouse ESCs, SOX2/OCT4 bind to canonical motifs (CTTTGTCATGCAAAT-like), which are composite SOX (CATTGTC-like) and OCT (ATGCAAAT-like) motifs|This way SOX17 and SOX2 regulate a common set of pluripotency and GC-related genes (PRDM14, DPPA4, TDGF1, NANOG, LIN28A, TRIM71, OTX2, PIM2) (Fig. 6). Additionally, in TCam-2 cells SOX17 binds to compressed motifs or SOX motifs (not bound by SOX2 in ECs), thereby regulating the PGC specifiers PRDM1 and TFAP2C, the GC-related genes NANOS3 and BMP7 and the cancer-related genes MYC and IGF1 (Fig. 6). In 2102EP cells, SOX2 further binds canonical elements or SOX motifs (not bound by SOX17 in TCam-2), regulating additional pluripotency genes (GDF3, LEFTY2, SALL4, SOX2 and POU5F1) (Fig. 6). |
|
| Publications: |
1 |
3.0
BMP7
- 
- 