Summary

Name GRIN1
Full Name Glutamate receptor ionotropic, NMDA 1
Synonyms GluN1, Glutamate [NMDA] receptor subunit zeta-1, N-methyl-D-aspartate receptor subunit NR1, NMD-R1 | NMDAR1
Primary ID Q05586
Links - -
Type protein
Relations 8
Function Component of NMDA receptor complexes that function as heterotetrameric, ligand-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Channel activation requires binding of the neurotransmitter glutamate to the epsilon subunit, glycine binding to the zeta subunit, plus membrane depolarization to eliminate channel inhibition by Mg(2+) (PubMed:7685113, PubMed:28126851, PubMed:26919761, PubMed:26875626, PubMed:28105280). Sensitivity to glutamate and channel kinetics depend on the subunit composition (PubMed:26919761).

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Modifications Tables

Relations

Regulator Mechanism target score
+ up-regulates activity img/direct-activation.png phosphorylation GRIN1 0.359
Publications: 1 Organism: Rattus Norvegicus
+ up-regulates activity img/direct-activation.png phosphorylation GRIN1 0.429
Publications: 1 Organism: Rattus Norvegicus
+ up-regulates activity img/direct-activation.png binding GRIN1 0.59
Publications: 1 Organism: Mus Musculus
+ form complex img/form-complex.png binding NMDA receptor_2B 0.711
Publications: 1 Organism: Homo Sapiens
+ form complex img/form-complex.png binding NMDA receptor_2D 0.644
Publications: 1 Organism: Homo Sapiens
+ form complex img/form-complex.png binding NMDA receptor_2A 0.709
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by destabilization img/direct_inhibition.png ubiquitination GRIN1 0.292
Publications: 1 Organism: In Vitro
+ form complex img/form-complex.png binding NMDA receptor_2C 0.59
Publications: 1 Organism: Homo Sapiens