Relation Results

Summary

Name GRIN1
Full Name Glutamate receptor ionotropic, NMDA 1
Synonyms GluN1, Glutamate [NMDA] receptor subunit zeta-1, N-methyl-D-aspartate receptor subunit NR1, NMD-R1 | NMDAR1
Primary ID Q05586
Links - -
Type protein
Relations 8
Function Component of NMDA receptor complexes that function as heterotetrameric, ligand-gated ion channels with high calcium permeability and voltage-dependent ...
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Type: Score: Layout: SPV 
0.3520.4190.2880.6090.7240.6610.6090.726PRKCGGRIN1PRKCALNX1NMDA receptor_2CNMDA receptor_2ANMDA receptor_2DGRIN2CNMDA receptor_2B

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▶Modifications Tables

Relations
Regulator
Mechanism
target
score ℹ
+ PRKCGup-regulates activity img/direct-activation.png phosphorylation GRIN1 0.352
Identifier Residue Sequence Organism Cell Line
SIGNOR-263176 Ser890 ITSTLASsFKRRRSS Rattus norvegicus Neuron
pmid sentence
Serines 890 and 896 of the NMDA receptor subunit NR1 are differentially phosphorylated by protein kinase C isoforms. The results show that PKC alpha phosphorylates preferentially S896 and PKC gamma preferentially S890.
Publications: 1 Organism: Rattus Norvegicus
+ PRKCAup-regulates activity img/direct-activation.png phosphorylation GRIN1 0.419
Identifier Residue Sequence Organism Cell Line
SIGNOR-263177 Ser896 SSFKRRRsSKDTSTG Rattus norvegicus Neuron
pmid sentence
Serines 890 and 896 of the NMDA receptor subunit NR1 are differentially phosphorylated by protein kinase C isoforms. The results show that PKC alpha phosphorylates preferentially S896 and PKC gamma preferentially S890.
Publications: 1 Organism: Rattus Norvegicus
+ LNX1down-regulates quantity by destabilization img/direct_inhibition.png ubiquitination GRIN1 0.288
Identifier Residue Sequence Organism Cell Line
SIGNOR-272901 in vitro
pmid sentence
We used the Ligand of Numb protein X (LNX) family of E3s, a group of PDZ domain-containing RING-type E3 ubiquitin ligases, to demonstrate the feasibility of this strategy. Many potential substrates of LNX E3s were identified. Eight of the nine selected candidates were ubiquitinated in vitro, and two novel endogenous substrates, PDZ-binding kinase (PBK) and breakpoint cluster region protein (BCR), were confirmed in vivo.
Publications: 1 Organism: In Vitro
+ GRIN1form complex img/form-complex.png binding NMDA receptor_2C 0.609
Identifier Residue Sequence Organism Cell Line
SIGNOR-264124 Homo sapiens Neuron
pmid sentence
The NMDA receptor, a ligand-gated ion channel composed of the NR1 and NR2 subunits, is located mainly at synapses of CNS neurons. The NMDA receptor subtypes are encoded by three gene families that process mRNA transcripts to yield six distinct subunits (NR1, NR2A-2D, NR3A). Receptors are thought to be tetrameric complexes of two NR1 and two NR2 subunits
Publications: 1 Organism: Homo Sapiens
+ GRIN1form complex img/form-complex.png binding NMDA receptor_2A 0.724
Identifier Residue Sequence Organism Cell Line
SIGNOR-264120 Homo sapiens Neuron
pmid sentence
The NMDA receptor, a ligand-gated ion channel composed of the NR1 and NR2 subunits, is located mainly at synapses of CNS neurons. The NMDA receptor subtypes are encoded by three gene families that process mRNA transcripts to yield six distinct subunits (NR1, NR2A-2D, NR3A). Receptors are thought to be tetrameric complexes of two NR1 and two NR2 subunits
Publications: 1 Organism: Homo Sapiens
+ GRIN1form complex img/form-complex.png binding NMDA receptor_2D 0.661
Identifier Residue Sequence Organism Cell Line
SIGNOR-264126 Homo sapiens Neuron
pmid sentence
The NMDA receptor, a ligand-gated ion channel composed of the NR1 and NR2 subunits, is located mainly at synapses of CNS neurons. The NMDA receptor subtypes are encoded by three gene families that process mRNA transcripts to yield six distinct subunits (NR1, NR2A-2D, NR3A). Receptors are thought to be tetrameric complexes of two NR1 and two NR2 subunits
Publications: 1 Organism: Homo Sapiens
+ GRIN2Cup-regulates activity img/direct-activation.png binding GRIN1 0.609
Identifier Residue Sequence Organism Cell Line
SIGNOR-262621 Mus musculus Cerebellar Granule Cell
pmid sentence
Here, we demonstrate that PKB/Akt directly phosphorylates NR2C on serine 1096 (S1096). In addition, we identify 14-3-3epsilon as an NR2C interactor, whose binding is dependent on S1096 phosphorylation. These data are all consistent with a model in which NR1 and NR2C oligomerize, PKB phosphorylates S1096, and 14-3-3ε binds to phosphorylated NR2C thereby promoting NR2C-containing NMDA receptor surface expression in cerebellar granule cells.
Publications: 1 Organism: Mus Musculus
+ GRIN1form complex img/form-complex.png binding NMDA receptor_2B 0.726
Identifier Residue Sequence Organism Cell Line
SIGNOR-264122 Homo sapiens Neuron
pmid sentence
The NMDA receptor, a ligand-gated ion channel composed of the NR1 and NR2 subunits, is located mainly at synapses of CNS neurons. The NMDA receptor subtypes are encoded by three gene families that process mRNA transcripts to yield six distinct subunits (NR1, NR2A-2D, NR3A). Receptors are thought to be tetrameric complexes of two NR1 and two NR2 subunits
Publications: 1 Organism: Homo Sapiens
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