| + |
IL10RB | up-regulates 
binding
|
TYK2 |
0.667 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-68013 |
|
|
Homo sapiens |
Macrophage, B-lymphocyte |
| pmid |
sentence |
| 10347215 |
Specifically, il-10 effects the activation of jak1 (associated with the il-10 receptor ? Chain) and tyk2 (associated with the il-10 receptor ? Chain) and induces the activation of stat1, stat3, and, in some cells, stat5. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
IL22 | up-regulates
binding
|
IL10RB |
0.709 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-151880 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 17208301 |
See table 2 |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
IL10 | up-regulates
binding
|
IL10RB |
0.727 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-83191 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 11035029 |
The il-10r2 chain is ubiquitously expressed, whereas the il-10 activity is restricted mainly to cells of hematopoietic origin (35, 36). This raised the question of why the second chain of the il-10 receptor complex is widely expressed when its function was required only in limited cellular subsets. One hypothesis is that the il-10r2 chain is shared by receptors for ligands other than il-10 |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-68007 |
|
|
Homo sapiens |
Macrophage, B-lymphocyte |
| pmid |
sentence |
| 10347215 |
Functionally active il-10 receptors are composed of two distinct subunits. The il-10 receptor ? Chain is a 110-kda polypeptide that plays the dominant role in mediating high affinity ligand binding and signal transduction. The il-10 receptor ? Subunit (also known as crf2_4) is predicted to be a 40-kda polypeptide that is largely required only for signaling. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| Tissue: |
Kidney |
| + |
IFNL2 | up-regulates
binding
|
IL10RB |
0.712 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-96209 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 12469119 |
Il-28 and il-29 interacted with a heterodimeric class ii cytokine receptor that consisted of il-10 receptor beta (il-10rbeta) and an orphan class ii receptor chain, designated il-28ralpha. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
IFNL3 | up-regulates
binding
|
IL10RB |
0.853 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-96246 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 12469119 |
Il-28 and il-29 interacted with a heterodimeric class ii cytokine receptor that consisted of il-10 receptor beta (il-10rbeta) and an orphan class ii receptor chain, designated il-28ralpha. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
IFNL1 | up-regulates
binding
|
IL10RB |
0.634 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-96177 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 12469119 |
Il-28 and il-29 interacted with a heterodimeric class ii cytokine receptor that consisted of il-10 receptor beta (il-10rbeta) and an orphan class ii receptor chain, designated il-28ralpha. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
IL26 | up-regulates
binding
|
IL10RB |
0.62 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-151917 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 17208301 |
See table 2 |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
4.0
IL10RB
- 
- 