| + |
CRP | down-regulates quantity by repression 
translation regulation
|
IL10 |
0.481 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-251824 |
|
|
Homo sapiens |
Macrophage |
| pmid |
sentence |
| 16917108 |
CRP significantly decreased IL-10 mRNA stability |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
IRF5 | down-regulates
transcriptional regulation
|
IL10 |
0.436 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254514 |
|
|
Homo sapiens |
Macrophage |
| pmid |
sentence |
| 21240265 |
The role of IRF5 in inhibiting the transcription of the gene encoding IL-10 that we have identified here is important given its well- documented immunosuppressive activity. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
STAT3 | up-regulates 
transcriptional regulation
|
IL10 |
0.783 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254515 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 22378047 |
IL-10 activates STAT3-mediated expression of genes (Il10, Tgfb1, Mrc1) associated with an M2-like phenotype |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-256234 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 28713870 |
These data argue that, in TH2 cells, STAT3 is required for T cell IL-10 production, which in turn reinforces its own expression |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| Pathways: | Macrophage polarization, Multiple sclerosis, SARS-CoV CYTOKINE STORM |
| + |
IL10 | down-regulates quantity by repression
transcriptional regulation
|
SCN1A |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253497 |
|
|
Rattus norvegicus |
|
| pmid |
sentence |
| 23357618 |
Interleukin-10 down-regulates voltage gated sodium channels in rat dorsal root ganglion neurons. Consistent with the electrophysiological results, real-time PCR and western blot revealed that IL-10 (200 pg/ml) down-regulated VGSCs in both mRNA and protein levels and reversed the up-regulation of VGSCs by TNF-α. |
|
| Publications: |
1 |
Organism: |
Rattus Norvegicus |
| + |
FOXP3 | up-regulates quantity by expression
transcriptional regulation
|
IL10 |
0.508 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254525 |
|
|
Homo sapiens |
T-lymphocyte |
| pmid |
sentence |
| 24315995 |
FoxP3, a lineage-specification factor, executes its multiple activities mostly through transcriptional regulation of target genes. We identified an interleukin-10 (IL-10)-producing FoxP3(+) T regulatory cell population that contributes to IL-10-dependent type 2 cytokine bias in breast-cancer patients. Although genetic ablation of FOXP3 inhibited IL10 transcription, genome-wide analysis ruled out its role as a transcription factor for IL10 |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
PPARG | up-regulates quantity by expression
transcriptional regulation
|
IL10 |
0.379 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-271688 |
|
|
|
|
| pmid |
sentence |
| 20553736 |
Pigment epithelium-derived factor induces interleukin-10 expression in human macrophages by induction of PPAR gamma. |
|
| Publications: |
1 |
| Pathways: | Macrophage polarization |
| + |
CRP | down-regulates quantity
post transcriptional regulation
|
IL10 |
0.481 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-251825 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 16917108 |
CRP significantly decreased IL-10 mRNA stability |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
IL10 | down-regulates quantity by repression
transcriptional regulation
|
SCN4A |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253500 |
|
|
Rattus norvegicus |
|
| pmid |
sentence |
| 23357618 |
Interleukin-10 down-regulates voltage gated sodium channels in rat dorsal root ganglion neurons. Consistent with the electrophysiological results, real-time PCR and western blot revealed that IL-10 (200 pg/ml) down-regulated VGSCs in both mRNA and protein levels and reversed the up-regulation of VGSCs by TNF-α. |
|
| Publications: |
1 |
Organism: |
Rattus Norvegicus |
| + |
FLI1 | up-regulates
transcriptional regulation
|
IL10 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254516 |
|
|
Homo sapiens |
Macrophage |
| pmid |
sentence |
| 20879862 |
In terms of cytokine expression, increased FLI-1 levels specifically enhanced IL-10 expression |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
IL10 | down-regulates quantity by repression
transcriptional regulation
|
SCN11A |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253502 |
|
|
Rattus norvegicus |
|
| pmid |
sentence |
| 23357618 |
Interleukin-10 down-regulates voltage gated sodium channels in rat dorsal root ganglion neurons. Consistent with the electrophysiological results, real-time PCR and western blot revealed that IL-10 (200 pg/ml) down-regulated VGSCs in both mRNA and protein levels and reversed the up-regulation of VGSCs by TNF-α. |
|
| Publications: |
1 |
Organism: |
Rattus Norvegicus |
| + |
IL10 | down-regulates quantity by repression
transcriptional regulation
|
SCN10A |
0.267 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253503 |
|
|
Rattus norvegicus |
Neuron |
| pmid |
sentence |
| 23357618 |
Interleukin-10 down-regulates voltage gated sodium channels in rat dorsal root ganglion neurons. Consistent with the electrophysiological results, real-time PCR and western blot revealed that IL-10 (200 pg/ml) down-regulated VGSCs in both mRNA and protein levels and reversed the up-regulation of VGSCs by TNF-α. |
|
| Publications: |
1 |
Organism: |
Rattus Norvegicus |
| Tissue: |
Spinal Ganglion |
| + |
IL10 | up-regulates activity 
binding
|
IL10RA |
0.911 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-249544 |
|
|
Homo sapiens |
Macrophage |
| pmid |
sentence |
| 26260587 |
IL10 is a classic anti-inflammatory cytokine and its molecular signalling pathway has been well characterized in macrophages and T lymphocytes. Secreted IL10 cytokine binds to the IL10 receptor 1 (IL10R1) on membrane surfaces, and IL10R1 dimerizes with IL10R2 to exert its downstream effects. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Macrophage polarization, Multiple sclerosis, SARS-CoV CYTOKINE STORM |
| + |
IL10 | up-regulates
binding
|
IL10RB |
0.704 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-68007 |
|
|
Homo sapiens |
Macrophage, B-lymphocyte |
| pmid |
sentence |
| 10347215 |
Functionally active il-10 receptors are composed of two distinct subunits. The il-10 receptor ? Chain is a 110-kda polypeptide that plays the dominant role in mediating high affinity ligand binding and signal transduction. The il-10 receptor ? Subunit (also known as crf2_4) is predicted to be a 40-kda polypeptide that is largely required only for signaling. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-83191 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 11035029 |
The il-10r2 chain is ubiquitously expressed, whereas the il-10 activity is restricted mainly to cells of hematopoietic origin (35, 36). This raised the question of why the second chain of the il-10 receptor complex is widely expressed when its function was required only in limited cellular subsets. One hypothesis is that the il-10r2 chain is shared by receptors for ligands other than il-10 |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| Tissue: |
Kidney |
| + |
IL10 | up-regulates quantity by expression
transcriptional regulation
|
IL1RN |
0.601 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254793 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 20032313 |
The interleukin 1 receptor antagonist (IL-1ra) is an important negative regulator of the inflammatory response, whose genetic deficiency has been recently shown to cause a severe autoinflammatory syndrome in humans. In this study we characterized the molecular mechanisms whereby interleukin 10 (IL-10) potentiates IL-1ra transcription in LPS-stimulated monocytes and neutrophils. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | SARS-CoV CYTOKINE STORM |
| + |
CREB1 | up-regulates quantity by expression
transcriptional regulation
|
IL10 |
0.442 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254522 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 10540320 |
Our data suggest that intracellular cAMP may directly affect expression of the immunoregulatory cytokine IL-10 in monocytic cells via activation of the eukaryotic transcription factors CREB-1 and ATF-1 and their binding to CRE1 and CRE4 in the upstream enhancer of the IL-10 promoter |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
IL10 | up-regulates
binding
|
IL10RA |
0.911 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-67964 |
|
|
Homo sapiens |
Macrophage, B-lymphocyte |
| pmid |
sentence |
| 10347215 |
Functionally active il-10 receptors are composed of two distinct subunits. The il-10 receptor ? Chain is a 110-kda polypeptide that plays the dominant role in mediating high affinity ligand binding and signal transduction. The il-10 receptor ? Subunit (also known as crf2_4) is predicted to be a 40-kda polypeptide that is largely required only for signaling |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Macrophage polarization, Multiple sclerosis, SARS-CoV CYTOKINE STORM |
| + |
IRF5 | down-regulates quantity by repression
transcriptional regulation
|
IL10 |
0.436 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-249509 |
|
|
Homo sapiens |
Macrophage |
| pmid |
sentence |
| 22025054 |
IRF5 is directly recruited to gene promoters associated with the M1 phenotype (including Il12b), but it represses Il10, probably also by binding to an ISRE in the gene promoter |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
TBX21 | down-regulates quantity by repression
transcriptional regulation
|
IL10 |
0.46 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254524 |
|
|
Mus musculus |
T-lymphocyte |
| pmid |
sentence |
| 20154735 |
Similarly, an increase in IL-10 expression was observed in mice deficient for the TH1 cell-specific transcription factor T-bet (also known as TBX21) that were infected with M.tuberculosis, suggesting that T-bet might have a role in the negative regulation of IL-10 expression by TH1 cells |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
IL10 | down-regulates quantity by repression
transcriptional regulation
|
SCN3A |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253504 |
|
|
Rattus norvegicus |
|
| pmid |
sentence |
| 23357618 |
Interleukin-10 down-regulates voltage gated sodium channels in rat dorsal root ganglion neurons. Consistent with the electrophysiological results, real-time PCR and western blot revealed that IL-10 (200 pg/ml) down-regulated VGSCs in both mRNA and protein levels and reversed the up-regulation of VGSCs by TNF-α. |
|
| Publications: |
1 |
Organism: |
Rattus Norvegicus |
| + |
CEBPB | up-regulates quantity by expression
transcriptional regulation
|
IL10 |
0.364 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254523 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 12493739 |
The C/EBP5 motif, which is located between the TATA-box and the translation start point, is essential for the C/EBP-mediated constitutive and most of the cAMP-stimulated expression as its mutation nearly abolished IL-10 promoter activity. Our results suggest a dominant role of C/EBP transcription factors relative to CREB/ATF in tissue-specific and differentiation-dependent IL-10 transcription |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
TRAF3 | up-regulates quantity by expression
transcriptional regulation
|
IL10 |
0.337 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-256077 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 16306937 |
TRAF3 is essential for the induction of type I interferons (IFN) and the anti-inflammatory cytokine interleukin-10 (IL-10), but is dispensable for expression of pro-inflammatory cytokines. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
ERK1/2 | up-regulates quantity
|
IL10 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-256080 |
|
|
Mus musculus |
Bone Marrow-derived Macrophage |
| pmid |
sentence |
| 26208884 |
The mitogen activated protein kinases ERK1/2 play an important role in response to toll like receptor (TLR) activation and cytokine production, including IL-10 and IL-12. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
M2_polarization | up-regulates quantity by expression
|
IL10 |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255448 |
|
|
|
|
| pmid |
sentence |
| 22933625 |
P38 activation contributes to the macrophage phenotype switch in injured muscle, which could elevate production of IL-10 (63), creating positive feedback for the phenotype switch |
|
| Publications: |
1 |
| Pathways: | Macrophage polarization, Multiple sclerosis |
| + |
IL10 | down-regulates quantity by repression
transcriptional regulation
|
SCN8A |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253501 |
|
|
Rattus norvegicus |
Neuron |
| pmid |
sentence |
| 23357618 |
Interleukin-10 down-regulates voltage gated sodium channels in rat dorsal root ganglion neurons. Consistent with the electrophysiological results, real-time PCR and western blot revealed that IL-10 (200 pg/ml) down-regulated VGSCs in both mRNA and protein levels and reversed the up-regulation of VGSCs by TNF-α. |
|
| Publications: |
1 |
Organism: |
Rattus Norvegicus |
| Tissue: |
Spinal Ganglion |
| + |
IL10 | down-regulates quantity by repression
transcriptional regulation
|
SCN2A |
0.274 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253499 |
|
|
Rattus norvegicus |
|
| pmid |
sentence |
| 23357618 |
Interleukin-10 down-regulates voltage gated sodium channels in rat dorsal root ganglion neurons. Consistent with the electrophysiological results, real-time PCR and western blot revealed that IL-10 (200 pg/ml) down-regulated VGSCs in both mRNA and protein levels and reversed the up-regulation of VGSCs by TNF-α. |
|
| Publications: |
1 |
Organism: |
Rattus Norvegicus |
| + |
IL10 | down-regulates quantity by repression
transcriptional regulation
|
SCN5A |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253496 |
|
|
Rattus norvegicus |
Neuron |
| pmid |
sentence |
| 23357618 |
Interleukin-10 down-regulates voltage gated sodium channels in rat dorsal root ganglion neurons. Consistent with the electrophysiological results, real-time PCR and western blot revealed that IL-10 (200 pg/ml) down-regulated VGSCs in both mRNA and protein levels and reversed the up-regulation of VGSCs by TNF-α. |
|
| Publications: |
1 |
Organism: |
Rattus Norvegicus |
| Tissue: |
Spinal Ganglion |
| + |
M2_polarization | up-regulates
|
IL10 |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-263823 |
|
|
Homo sapiens |
Macrophage |
| pmid |
sentence |
| 32454942 |
Macrophages and microglia show a high plasticity and have been arbitrarily classified into “M1” (proinflammatory) and “M2” (prorepair, anti-inflammatory) phenotypes depending on their activation state, although it is now widely accepted that this classification is hugely oversimplified, particularly for microglia, and only partially reflects the real situation. M2 polarized cells express a variety of anti-inflammatory mediators, such as IL-4, IL-10, and transforming growth factor-β (TGF-β), and contribute to immunoregulation |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Macrophage polarization, Multiple sclerosis |
| + |
ATF1 | up-regulates quantity by expression
transcriptional regulation
|
IL10 |
0.252 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254521 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 10540320 |
Our data suggest that intracellular cAMP may directly affect expression of the immunoregulatory cytokine IL-10 in monocytic cells via activation of the eukaryotic transcription factors CREB-1 and ATF-1 and their binding to CRE1 and CRE4 in the upstream enhancer of the IL-10 promoter |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
IL10 | down-regulates quantity by repression
transcriptional regulation
|
SCN9A |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253498 |
|
|
Rattus norvegicus |
|
| pmid |
sentence |
| 23357618 |
Interleukin-10 down-regulates voltage gated sodium channels in rat dorsal root ganglion neurons. Consistent with the electrophysiological results, real-time PCR and western blot revealed that IL-10 (200 pg/ml) down-regulated VGSCs in both mRNA and protein levels and reversed the up-regulation of VGSCs by TNF-α. |
|
| Publications: |
1 |
Organism: |
Rattus Norvegicus |
3.0
IL10
- 
- 