Summary

Name CBX3
Full Name Chromobox protein homolog 3
Synonyms HECH, Heterochromatin protein 1 homolog gamma, HP1 gamma, Modifier 2 protein
Primary ID Q13185
Links - -
Type protein
Relations 7
Function Seems to be involved in transcriptional silencing in heterochromatin-like complexes. Recognizes and binds histone H3 tails methylated at 'Lys-9', leading to epigenetic repression. May contribute to the association of the heterochromatin with the inner nuclear membrane through its interaction with lamin B receptor (LBR). Involved in the formation of functional kinetochore through interaction with MIS12 complex proteins. Contributes to the conversion of local chromatin to a heterochromatin-like repressive state through H3 'Lys-9' trimethylation, mediates the recruitment of the methyltransferases SUV39H1 and/or SUV39H2 by the PER complex to the E-box elements of the circadian target genes such as PER2 itself or PER1. Mediates the recruitment of NIPBL to sites of DNA damage at double-strand breaks (DSBs) (PubMed:28167679).

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▶Modifications Tables

Relations

Regulator Mechanism target score ℹ
+ PRKACAup-regulates img/direct-activation.png phosphorylation CBX3 0.2
Publications: 1 Organism: Homo Sapiens
+ CBX3up-regulates activity img/direct-activation.png binding H3-3A 0.2
Publications: 1 Organism: Homo Sapiens
+ CBX3up-regulates activity img/direct-activation.png binding NIPBL 0.447
Publications: 1 Organism: Homo Sapiens
+ CBX3up-regulates activity img/direct-activation.png binding Histone H3 0.2
Publications: 1 Organism: Homo Sapiens
+ CBX3form complex img/form-complex.png binding ChAHP 0.416
Publications: 1 Organism: Mus Musculus
+ CBX3up-regulates activity img/direct-activation.png binding H3-4 0.2
Publications: 1 Organism: Homo Sapiens
+ CBX3up-regulates activity img/direct-activation.png binding H3C1 0.2
Publications: 1 Organism: Homo Sapiens