Relation Results

Summary

Name TBX2
Full Name T-box transcription factor TBX2
Synonyms T-box protein 2
Primary ID Q13207
Links - -
Type protein
Relations 7
Pathways Rhabdomyosarcoma
Function Involved in the transcriptional regulation of genes required for mesoderm differentiation. Probably plays a role in limb pattern formation. Acts as a ...
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Type: Score: Layout: SPV 
0.70.2510.5010.3510.3520.70.315TBX2Skeletal_muscle_differentiationMYOGCDKN2ACDKN1APAX3ProliferationMYOD1

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Relations
Regulator
Mechanism
target
score ℹ
+ TBX2down-regulates img/indirect_inhibition.png Skeletal_muscle_differentiation 0.7
Identifier Residue Sequence Organism Cell Line
SIGNOR-251563 Homo sapiens
pmid sentence
TBX2 blocks myogenesis and promotes proliferation in rhabdomyosarcoma cells
Publications: 1 Organism: Homo Sapiens
Pathways:Rhabdomyosarcoma
+ TBX2down-regulates activity img/direct_inhibition.png binding MYOG 0.251
Identifier Residue Sequence Organism Cell Line
SIGNOR-251561 Homo sapiens
pmid sentence
We have found that TBX2 is highly up regulated in both ERMS and ARMS subtypes of RMS and demonstrate that TBX2 is a repressor of myogenesis by binding to MyoD and myogenin and inhibiting their activity.
Publications: 1 Organism: Homo Sapiens
Pathways:Rhabdomyosarcoma
+ TBX2down-regulates quantity by repression img/direct_inhibition.png transcriptional regulation CDKN2A 0.501
Identifier Residue Sequence Organism Cell Line
SIGNOR-249594 Homo sapiens
pmid sentence
TBX2 and TBX3 function as transcriptional repressors and both have been shown to inhibit myogenesis (Carlson et al, 2002; Zhu et al, 2014). Abnormal expression of TBX2 has been reported in several cancers including breast, pancreas, and melanoma, where it has been shown to drive proliferation (reviewed in Abrahams et al (2010)). As has been previously shown in other cell types, TBX2 was found to induce a downregulation of p14/19ARF and function as a direct repressor of p21 in RMS
Publications: 1 Organism: Homo Sapiens
+ TBX2down-regulates quantity by repression img/direct_inhibition.png transcriptional regulation CDKN1A 0.351
Identifier Residue Sequence Organism Cell Line
SIGNOR-249593 Homo sapiens Rhabdomyosarcoma Cell Line
pmid sentence
TBX2 and TBX3 function as transcriptional repressors and both have been shown to inhibit myogenesis (Carlson et al, 2002; Zhu et al, 2014). Abnormal expression of TBX2 has been reported in several cancers including breast, pancreas, and melanoma, where it has been shown to drive proliferation (reviewed in Abrahams et al (2010)). As has been previously shown in other cell types, TBX2 was found to induce a downregulation of p14/19ARF and function as a direct repressor of p21 in RMS
Publications: 1 Organism: Homo Sapiens
Pathways:Rhabdomyosarcoma
+ PAX3up-regulates quantity by expression img/direct-activation.png transcriptional regulation TBX2 0.352
Identifier Residue Sequence Organism Cell Line
SIGNOR-249596 Homo sapiens Rhabdomyosarcoma Cell Line
pmid sentence
We have recently found that a T-box gene family member, TBX2, is highly overexpressed in both ERMS and ARMS cells (Zhu et al, 2014). The regulation of TBX2 is uncharacterised in RMS cells, but is likely to link TBX2 expression to the known deregulation of signalling pathways in RMS. In melanoma cells, TBX2 is regulated by PAX3
Publications: 1 Organism: Homo Sapiens
Pathways:Rhabdomyosarcoma
+ TBX2up-regulates img/indirect-activation.png Proliferation 0.7
Identifier Residue Sequence Organism Cell Line
SIGNOR-251562 Homo sapiens
pmid sentence
TBX2 blocks myogenesis and promotes proliferation in rhabdomyosarcoma cells
Publications: 1 Organism: Homo Sapiens
Pathways:Rhabdomyosarcoma
+ TBX2down-regulates activity img/direct_inhibition.png binding MYOD1 0.315
Identifier Residue Sequence Organism Cell Line
SIGNOR-251560 Homo sapiens
pmid sentence
We have found that TBX2 is highly up regulated in both ERMS and ARMS subtypes of RMS and demonstrate that TBX2 is a repressor of myogenesis by binding to MyoD and myogenin and inhibiting their activity.
Publications: 1 Organism: Homo Sapiens
Pathways:Rhabdomyosarcoma
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