| + |
SYK | up-regulates activity 
phosphorylation
|
IL15RA |
0.334 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-246556 |
Tyr227 |
AVSLLACyLKSRQTP |
Homo sapiens |
RAJI Cell |
| pmid |
sentence |
| 11714793 |
Mutation of a defined region of the intracellular signaling portion of IL-15Ralpha (Tyr227) abrogates both the IL-15Ralpha/Syk association and IL-15Ralpha phosphorylation. Taken together, this suggests that Syk kinase physically and functionally associates with the IL-15Ralpha chain in B cells and that Syk plays a key role in mediating IL-15-induced signal transduction, thus accounting for the distinct functional consequences of IL-15 vs IL-2 binding to B cells |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
IL15RA | up-regulates 
|
TIMP3 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-256232 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 30029643 |
Since recent study demonstrated desert Hedgehog (DHH) signaling can repressed FAP-derived adipocyte differentiation through Timp3 [30], we tested the mRNA expression of DHH and Timp3 in injured muscle with injection of IL-15. As expected, mRNA levels of DHH and Timp3 were both upregulated (Fig. 2f). |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
IL15RA | up-regulates
, phosphorylation
|
JAK3 |
0.478 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-256226 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 30029643 |
Since Jak-STAT pathway primarily activated in IL-15-me- diated cell proliferation, we tested whether it is also participates in IL-15-mediated proliferation of FAPs. Interestingly, we found the expression of phospho-Jak3 and phospho-Tyk2, as well as their downstream, phospho- STAT3 and phospho-STAT5, was significantly upregulated |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-256225 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 30029643 |
Since Jak-STAT pathway primarily activated in IL-15-me- diated cell proliferation, we tested whether it is also participates in IL-15-mediated proliferation of FAPs. Interestingly, we found the expression of phospho-Jak3 and phospho-Tyk2, as well as their downstream, phospho- STAT3 and phospho-STAT5, was significantly upregulated |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
IL15RA | up-regulates
|
TYK2 |
0.248 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-256253 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 30029643 |
Since Jak-STAT pathway primarily activated in IL-15-me- diated cell proliferation, we tested whether it is also participates in IL-15-mediated proliferation of FAPs. Interestingly, we found the expression of phospho-Jak3 and phospho-Tyk2, as well as their downstream, phospho- STAT3 and phospho-STAT5, was significantly upregulated |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
IL15RA | up-regulates
binding
|
IL2RB |
0.788 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-157418 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 17709786 |
The il-15 receptor comprises a heterotrimeric complex consisting of the common ?cytokine Receptor (?c), the il-2 ? Receptor subunit (il-2r?), And an il-15-specific ? Receptor (il-15r?) |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Tissue: |
Muscle, Skeletal Muscle |
| + |
IL15RA | down-regulates activity 
|
PPARG |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-256228 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 30029643 |
In addition, level of mRNAs encoding C/EBPa, PPARg and FABP4, the classic adipogenic markers, was significantly lower in samples administrated with IL-15 |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
IL15RA | up-regulates
|
JAK1 |
0.436 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-256227 |
|
|
|
T-lymphocyte |
| pmid |
sentence |
| 30029643 |
Since Jak-STAT pathway primarily activated in IL-15-me- diated cell proliferation, we tested whether it is also participates in IL-15-mediated proliferation of FAPs. Interestingly, we found the expression of phospho-Jak3 and phospho-Tyk2, as well as their downstream, phospho- STAT3 and phospho-STAT5, was significantly upregulated |
|
| Publications: |
1 |
| + |
IL15 | up-regulates
binding
|
IL15RA |
0.861 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-157415 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 17709786 |
Interleukin-15 specificity and high affinity binding are conferred by the IL-5-specific but nonsignaling IL-15R alpha subunit, which is structurally similar (but not homologous) to the alpha receptor subunit of IL-2 |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Tissue: |
Muscle, Skeletal Muscle |
3.0
IL15RA
- 
- 