Summary

Name PTPRS
Full Name Receptor-type tyrosine-protein phosphatase S
Synonyms R-PTP-S, Receptor-type tyrosine-protein phosphatase sigma, R-PTP-sigma
Primary ID Q13332
Links - -
Type protein
Relations 4
Function Cell surface receptor that binds to glycosaminoglycans, including chondroitin sulfate proteoglycans and heparan sulfate proteoglycan (PubMed:21454754). Binding to chondroitin sulfate and heparan sulfate proteoglycans has opposite effects on PTPRS oligomerization and regulation of neurite outgrowth. Contributes to the inhibition of neurite and axonal outgrowth by chondroitin sulfate proteoglycans, also after nerve transection. Plays a role in stimulating neurite outgrowth in response to the heparan sulfate proteoglycan GPC2. Required for normal brain development, especially for normal development of the pituitary gland and the olfactory bulb. Functions as tyrosine phosphatase (PubMed:8524829). Mediates dephosphorylation of NTRK1, NTRK2 and NTRK3 (By similarity). Plays a role in down-regulation of signaling cascades that lead to the activation of Akt and MAP kinases (By similarity). Down-regulates TLR9-mediated activation of NF-kappa-B, as well as production of TNF, interferon alpha and interferon beta (PubMed:26231120).

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Relations

Regulator Mechanism target score ℹ
+ LRFN5up-regulates activity img/direct-activation.png binding PTPRS 0.377
Publications: 1 Organism: Homo Sapiens
+ PTPRSdown-regulates activity img/direct_inhibition.png dephosphorylation EGFR 0.44
Publications: 1 Organism: Homo Sapiens
+ PTPRSup-regulates img/indirect-activation.png Synaptic_plasticity 0.7
Publications: 1 Organism: Homo Sapiens
+ HSPG2up-regulates img/direct-activation.png binding PTPRS 0.256
Publications: 1 Organism: Homo Sapiens