Relation Results

Summary

Name PTPRS
Full Name Receptor-type tyrosine-protein phosphatase S
Synonyms R-PTP-S, Receptor-type tyrosine-protein phosphatase sigma, R-PTP-sigma
Primary ID Q13332
Links - -
Type protein
Relations 4
Function Cell surface receptor that binds to glycosaminoglycans, including chondroitin sulfate proteoglycans and heparan sulfate proteoglycan (PubMed:21454754) ...
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Type: Score: Layout: SPV 
0.440.2550.3760.7PTPRSEGFRHSPG2LRFN5Synaptic_plasticity

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Relations
Regulator
Mechanism
target
score ℹ
+ PTPRSdown-regulates activity img/direct_inhibition.png dephosphorylation EGFR 0.44
Identifier Residue Sequence Organism Cell Line
SIGNOR-277145 Homo sapiens
pmid sentence
Similarly, Pestana et al. (89) have reported that overexpression of RPTPsigma in human A431 carcinoma cells partially inhibits EGFR activation, whereas antisense mediated suppression of RPTPsigma expression enhances EGFR activation, substrate phosphorylation, and signalling.|These data indicate that LAR and RPTPsigma may have a significant role in GPCR induced EGFR signalling.Whereas in A431 cells LAR and RPTPsigma may act to suppress the EGFR in response to GPCR activation, it is possible that the converse may also be true in other cell types.
Publications: 1 Organism: Homo Sapiens
+ HSPG2up-regulates img/direct-activation.png binding PTPRS 0.255
Identifier Residue Sequence Organism Cell Line
SIGNOR-115246 Homo sapiens
pmid sentence
We demonstrate here that cptpsigma is a heparin-binding protein and that its basal lamina ligands include the heparan sulfate proteoglycans (hspgs) agrin and collagen xviii.
Publications: 1 Organism: Homo Sapiens
+ LRFN5up-regulates activity img/direct-activation.png binding PTPRS 0.376
Identifier Residue Sequence Organism Cell Line
SIGNOR-264088 Homo sapiens
pmid sentence
SALM5 trans-synaptically interacts with LAR-RPTPs in a splicing-dependent manner to regulate synapse development. we identified LAR-RPTPs as novel ligands of SALM5 that mediates SALM5-dependent presynaptic differentiation in a splicing-dependent manner. Our data indicate that SALM5 interacts with all three known LAR-RPTPs—LAR, PTPδ, and PTPσ (Fig. 1).
Publications: 1 Organism: Homo Sapiens
+ PTPRSup-regulates img/indirect-activation.png Synaptic_plasticity 0.7
Identifier Residue Sequence Organism Cell Line
SIGNOR-264091 Homo sapiens Neuron
pmid sentence
LAR (for leukocyte common antigen-related) is a family of receptor protein tyrosine phosphatases (LAR-RPTPs) with three known members: LAR/PTPRF, PTPδ/PTPRD, and PTPσ/PTPRS. In mammals, LAR-RPTPs have been shown to regulate dendrite and excitatory synapse development and maintenance
Publications: 1 Organism: Homo Sapiens
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