3.0
Summary
| Name |  PDE3BView Modifications |
| Full Name | cGMP-inhibited 3',5'-cyclic phosphodiesterase B |
| Synonyms | CGIPDE1, CGIP1, Cyclic GMP-inhibited phosphodiesterase B, CGI-PDE B |
| Primary ID | Q13370 |
| Links |  -  -  |
| Type | protein |
| Relations | 7 |
| Function | Cyclic nucleotide phosphodiesterase with a dual-specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes. May play a role in fat metabolism. Regulates cAMP binding of RAPGEF3. Through simultaneous binding to RAPGEF3 and PIK3R6 assembles a signaling complex in which the PI3K gamma complex is activated by RAPGEF3 and which is involved in angiogenesis. |
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Modifications Tables
Relations
| Regulator | Mechanism | target | score ℹ | |
|---|---|---|---|---|
| + | AKT1 | up-regulates 
phosphorylation
|
PDE3B | 0.679 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | AKT | up-regulates activity
phosphorylation
|
PDE3B | 0.2 |
| Publications: | 2 | Organism: | Mus Musculus | |
| + | AKT1 | up-regulates activity
phosphorylation
|
PDE3B | 0.679 |
| Publications: | 2 | Organism: | Mus Musculus | |
| + | AKT | up-regulates
phosphorylation
|
PDE3B | 0.2 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | PRKACA |
phosphorylation
|
PDE3B | 0.462 |
| Publications: | 1 | Organism: | In Vitro | |