| + |
FRS2 | up-regulates 
binding
|
GRAP |
0.339 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-87169 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 11997436 |
Complex formation between grb2 and frs2_ is mediated by y196, y306, y349, and y392 of frs2_ (designated direct grb2-binding sites;ref. 1). In addition, frs2_ recruits grb2 indirectly by means of the protein tyrosine phosphatase shp2 by way of residues y436 and y471 (designated shp2-binding sites;ref. 2). |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
VAV1 | up-regulates
binding
|
GRAP |
0.297 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-33840 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 7809090 |
Here we report that both in cell extracts and within intact mammalian cells vav binds to grb2 (sem-5/ash/drk), an adaptor molecule which plays a key role in ras activation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
ABL1 | up-regulates
binding
|
GRAP |
0.267 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-200871 |
|
|
Homo sapiens |
Leukemia Cell |
| pmid |
sentence |
| 23399893 |
We show that the grb2-related adapter protein, gads, also associates with bcr-abl, specifically through y177 and demonstrate that bcr-abl-driven lymphoid disease requires gads |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SHC1 | up-regulates
binding
|
GRAP |
0.507 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-45528 |
|
|
Homo sapiens |
T-lymphocyte |
| pmid |
sentence |
| 8995379 |
T cell activation effects an increase in grap association with p36/38, shc, sos, and dynamin. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
MET | up-regulates
binding
|
GRAP |
0.269 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-42358 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 8662889 |
To efficiently promote transformation met requires direct binding with grb2. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
4.0
GRAP
- 
- 