| + |
FGFR1 | up-regulates activity 
phosphorylation
|
FRS2 |
0.868 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-280013 |
Tyr196 |
AEEQVHTyVNTTGVQ |
Homo sapiens |
|
| pmid |
sentence |
| 25394172 |
As shown in xref , wild type FGFR1c phosphorylated FRS2\u03b1 on tyrosine 196 whereas the V429E mutant did not. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-236944 |
|
|
Rattus norvegicus |
L-6 Myoblast Cell |
| pmid |
sentence |
| 9182757 |
In this report, we demonstrate that FGF stimulation induces tyrosine phosphorylation of a novel lipid anchored docking protein, termed FRS2, that forms a complex with Grb2/Sos, thus linking FGF-receptor activation to the Ras/MAPK signaling pathway. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens, Rattus Norvegicus |
| Pathways: | Luminal Breast Cancer |
| + |
FGFR4 | up-regulates activity
phosphorylation
|
FRS2 |
0.687 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-242661 |
|
|
Rattus norvegicus |
|
| pmid |
sentence |
| 9182757 |
In this report, we demonstrate that FGF stimulation induces tyrosine phosphorylation of a novel lipid anchored docking protein, termed FRS2, that forms a complex with Grb2/Sos, thus linking FGF-receptor activation to the Ras/MAPK signaling pathway. |
|
| Publications: |
1 |
Organism: |
Rattus Norvegicus |
| + |
CBL | down-regulates 
ubiquitination
|
FRS2 |
0.577 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-87166 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 11997436 |
The experiments presented in this report illustrate that in response to fgf stimulation, cbl is recruited by grb2 binding to the frs2_ multiprotein complex, resulting in ubiquitination of frs2_ and fgfr. grb2 functions as a link between frs2_ and cbl;grb2 is bound to tyrosine-phosphorylated frs2_ by means of its sh2 domain and to a proline-rich region in the c terminus of cbl by means of its sh3 domains. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
FRS2 | up-regulates
phosphorylation
|
PTPN11 |
0.782 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-58196 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 9632781 |
In addition to the direct interactions with grb2, tyrosine-phosphorylated frs2 forms a complex with the sh2 domain-containing protein tyrosine phosphatase shp2. This interaction results in tyrosine phosphorylation of shp2 and complex formation between shp2 and grb2. the catalytic activity of shp2 is essential for a sustained map kinase response and for potentiation of fgf-induced neurite outgrowth in pc12 cells |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
FRS2 | up-regulates activity
binding
|
GRB2 |
0.803 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-236953 |
|
|
Rattus norvegicus |
L-6 Myoblast Cell |
| pmid |
sentence |
| 9182757 |
In this report, we demonstrate that FGF stimulation induces tyrosine phosphorylation of a novel lipid anchored docking protein, termed FRS2, that forms a complex with Grb2/Sos, thus linking FGF-receptor activation to the Ras/MAPK signaling pathway. |
|
| Publications: |
1 |
Organism: |
Rattus Norvegicus |
| Pathways: | Luminal Breast Cancer |
| + |
FGFR2 | up-regulates activity
phosphorylation
|
FRS2 |
0.779 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-236950 |
|
|
Rattus norvegicus |
L-6 Myoblast Cell |
| pmid |
sentence |
| 9182757 |
In this report, we demonstrate that FGF stimulation induces tyrosine phosphorylation of a novel lipid anchored docking protein, termed FRS2, that forms a complex with Grb2/Sos, thus linking FGF-receptor activation to the Ras/MAPK signaling pathway. |
|
| Publications: |
1 |
Organism: |
Rattus Norvegicus |
| + |
FRS2 | up-regulates
binding
|
GRAP |
0.339 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-87169 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 11997436 |
Complex formation between grb2 and frs2_ is mediated by y196, y306, y349, and y392 of frs2_ (designated direct grb2-binding sites;ref. 1). In addition, frs2_ recruits grb2 indirectly by means of the protein tyrosine phosphatase shp2 by way of residues y436 and y471 (designated shp2-binding sites;ref. 2). |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
NTRK1 | up-regulates
binding
|
FRS2 |
0.778 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-65955 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 10092678 |
The signaling adapter frs-2 competes with shc for binding to the nerve growth factor receptor trka:a model for discriminating proliferation and differentiation |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
INSR | up-regulates activity
phosphorylation
|
FRS2 |
0.37 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-278945 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 10650943 |
We found that insulin receptor can directly phosphorylate FRS2. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Luminal Breast Cancer |
| + |
RET | up-regulates
binding
|
FRS2 |
0.679 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-108244 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 11360177 |
Tyrosine 1062 in ret provides a site for the interaction of multiple signaling molecules and that the balance of shc and snt/frs2 binding may affect the nature of the intracellular signaling for cell proliferation, differentiation and survival induced by activated ret |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
4.0
FRS2
- 
- 