| + |
LCK |
phosphorylation
|
VAV1 |
0.778 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-251389 |
Tyr142 |
SVGDEDIySGLSDQI |
in vitro |
|
| pmid |
sentence |
| 10669745 |
Lck recognizes preferentially the tyrosine residue of Vav located at position 174 and, with significantly less affinity, those present at positions 142 and 160. It is now clear that this posttranslational modification will be involved in the activation of Vav, in the regulation of the strength of the signals emanating from this molecule, and also in the negative regulation of its function. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-251390 |
Tyr160 |
VEEDEDLyDCVENEE |
in vitro |
|
| pmid |
sentence |
| 10669745 |
Lck recognizes preferentially the tyrosine residue of Vav located at position 174 and, with significantly less affinity, those present at positions 142 and 160. It is now clear that this posttranslational modification will be involved in the activation of Vav, in the regulation of the strength of the signals emanating from this molecule, and also in the negative regulation of its function. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-251391 |
Tyr174 |
EAEGDEIyEDLMRSE |
in vitro |
|
| pmid |
sentence |
| 10669745 |
Lck recognizes preferentially the tyrosine residue of Vav located at position 174 and, with significantly less affinity, those present at positions 142 and 160. It is now clear that this posttranslational modification will be involved in the activation of Vav, in the regulation of the strength of the signals emanating from this molecule, and also in the negative regulation of its function. |
|
| Publications: |
3 |
Organism: |
In Vitro |
| + |
SOCS1 | down-regulates quantity by destabilization 
binding
|
VAV1 |
0.583 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-272559 |
|
|
Chlorocebus aethiops |
COS-7 Cell |
| pmid |
sentence |
| 10747851 |
SOCS1 stimulates the polyubiquitination of VAV proteins in vivo, which was stabilized by proteasomal inhibitors. These results suggest that SOCS1 programs VAV degradation by acting as a substrate-specific recognition component of a VCB-like ubiquitin ligase complex. |
|
| Publications: |
1 |
Organism: |
Chlorocebus Aethiops |
| + |
LAT | up-regulates activity 
binding
|
VAV1 |
0.745 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-246045 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 11368773 |
By substituting these tyrosine residues in LAT with phenylalanine and by utilizing phosphorylated peptides derived from these sites, we mapped the tyrosine residues in LAT required for the direct interaction and activation of Vav, p85/p110alpha and phospholipase Cgamma1 (PLCgamma1). Our results indicate that Tyr(226) and Tyr(191) are required for Vav binding, whereas Tyr(171) and Tyr(132) are necessary for association and activation of phosphoinositide 3-kinase activity and PLCgamma1 respectively. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
VCB-Cul2 | down-regulates quantity by destabilization
polyubiquitination
|
VAV1 |
0.248 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-272563 |
|
|
Chlorocebus aethiops |
|
| pmid |
sentence |
| 10747851 |
Recent evidence indicates that SOCS1 interacts with elongins B and C, which are components of a ubiquitin ligase complex, VCB (VHL/elonginC/B), based on the VHL (von Hippel Lindau) tumor suppressor protein. |
|
| Publications: |
1 |
Organism: |
Chlorocebus Aethiops |
| + |
DNM2 | up-regulates quantity by stabilization
binding
|
VAV1 |
0.499 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-259080 |
|
|
Homo sapiens |
Pancreatic Cancer Cell |
| pmid |
sentence |
| 23537630 |
Disruption of the Dyn2-Vav1 interaction targets Vav1 to the lysosome for degradation via an interaction with the cytoplasmic chaperone Hsc70, resulting in a dramatic reduction of Vav1 protein stability. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
VAV1 | up-regulates 
|
ERK1/2 |
0.521 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-244640 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 9013873 |
Vav may link gp130 activation to downstream mapk activation in hematopoietic cells. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
VAV1 | up-regulates
|
MAPK1 |
0.521 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-46064 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 9013873 |
Vav may link gp130 activation to downstream mapk activation in hematopoietic cells. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
FYN | up-regulates
phosphorylation
|
VAV1 |
0.623 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-82287 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 11005864 |
Study of t cells from a fyn-deficient tcr transgenic mouse also showed that fyn was required for tyrosine phosphorylation and activation of vav induced by both antagonist and agonist peptides. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
VAV1 | up-regulates
binding
|
SYK |
0.918 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-107049 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 11331248 |
Vav interacts with the tyrosine kinase syk |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
VAV1 | up-regulates activity
binding
|
ZAP70 |
0.834 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-274150 |
|
|
Homo sapiens |
Hematopoietic Stem Cell |
| pmid |
sentence |
| 9151714 |
In summary, we demonstrate here that Y315 in ZAP-70 is required to interact with the Vav SH2 domain, and is critical for ZAP-70–mediated gene activation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CD19 | up-regulates activity
binding
|
VAV1 |
0.716 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-242897 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 25673924 |
CD19 has an extracellular region containing two C2-type Ig-like domains and a cytoplasmic region of ~240 amino acids with 9 conserved tyrosine residues24. Lyn, a Src-family protein tyrosine kinase member, is the dominant kinase that phosphorylates CD19 upon stimulation. Once tyrosyl-phosphorylated, CD19 serves as a membrane-bound adaptor protein for Src homology 2-containing signaling molecules such as Lyn, Vav, and phosphatidylinositol 3-kinase, which further mediate downstream activation cascades. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
PTPN6 | down-regulates activity
dephosphorylation
|
VAV1 |
0.564 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-277171 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 30567306 |
SHP-1 dephosphorylates and inactivates the guanine exchange factor Vav1. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
VAV1 | up-regulates
binding
|
GRAP |
0.301 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-33840 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 7809090 |
Here we report that both in cell extracts and within intact mammalian cells vav binds to grb2 (sem-5/ash/drk), an adaptor molecule which plays a key role in ras activation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
VAV1 | up-regulates
binding
|
GRB2 |
0.674 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-49362 |
|
|
Homo sapiens |
Leukemia Cell |
| pmid |
sentence |
| 9209406 |
Recently, we have shown that the proto-oncogene vav product (vav) is also tyrosine-phosphorylated by treatment with gm-csf and epo and is constitutively associated with the sh3 domain of grb2/ash in ut-7. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
VAV1 | up-regulates activity
guanine nucleotide exchange factor
|
RAC1 |
0.758 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-259081 |
|
|
Drosophila melanogaster |
|
| pmid |
sentence |
| 23525006 |
We identify the GTP exchange factor (GEF) Vav as a key regulator of Rac activity downstream of RTKs in a developmentally regulated cell migration event |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-260581 |
|
|
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 32203420 |
We therefore developed a screening-compatible live-cell imaging assay, using FRET-based biosensors for the prototype GTPases RHOA, RAC1 and CDC4215,19,20 (Extended Data Fig. 2 and Supplementary Note 1)|We found catalytic activities for 45/75 RhoGEFs and 48/63 RhoGAPs| Our data thus not only reveal extensive promiscuity among regulators, but also that the inactivating RhoGAPs are less selective than the activating RhoGEFs (p-value=0.02)(Supplementary Table 2). |
|
| Publications: |
2 |
Organism: |
Drosophila Melanogaster, Homo Sapiens |
| + |
VAV1 | up-regulates
binding
|
CBL |
0.683 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-49188 |
|
|
Homo sapiens |
T-lymphocyte |
| pmid |
sentence |
| 9200440 |
Hese data imply that c-cbl is a molecular adapter that regulates the function of vav |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
ABL1 | up-regulates
phosphorylation
|
VAV1 |
0.408 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-114091 |
|
|
Homo sapiens |
Leukemia Cell |
| pmid |
sentence |
| 11790798 |
Thus, the c-terminal tail of vav serves as a direct substrate of bcr-abl in vitro. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
BCR-ABL | up-regulates
phosphorylation
|
VAV1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-114094 |
|
|
Homo sapiens |
Leukemia Cell |
| pmid |
sentence |
| 11790798 |
Thus, the c-terminal tail of vav serves as a direct substrate of bcr-abl in vitro. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
VAV1 | up-regulates activity
guanine nucleotide exchange factor
|
RHOA |
0.742 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-260580 |
|
|
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 32203420 |
We therefore developed a screening-compatible live-cell imaging assay, using FRET-based biosensors for the prototype GTPases RHOA, RAC1 and CDC4215,19,20 (Extended Data Fig. 2 and Supplementary Note 1)|We found catalytic activities for 45/75 RhoGEFs and 48/63 RhoGAPs| Our data thus not only reveal extensive promiscuity among regulators, but also that the inactivating RhoGAPs are less selective than the activating RhoGEFs (p-value=0.02)(Supplementary Table 2). |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SYK | up-regulates
phosphorylation
|
VAV1 |
0.918 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-107046 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 11331248 |
Vav interacts with the tyrosine kinase syk. inhibition of syk kinase activity prevents tyrosine phosphorylation of vav and its interaction with pi 3-k. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
ZAP70 | up-regulates activity
phosphorylation
|
VAV1 |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-278390 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 23620790 |
These results suggest that CBAP may serve as an adaptor or scaffold in the integrin \u03b21/CBAP/ZAP70-containing complex that, upon chemokine treatment, would allow Vav1 or ZAP70 (or both) to adopt an optimal conformation(s) for ZAP70 to phosphorylate Vav1.|Together, these results suggested that CBAP is an important component in ZAP70 dependent activation of the Vav1 and Rac1 signaling axis. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
VAV1 | up-regulates
|
PRKCQ |
0.608 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-75827 |
|
|
Homo sapiens |
T-lymphocyte |
| pmid |
sentence |
| 10725744 |
Vav synergizes with protein kinase c theta to mediate il-4 gene expression in response to cd28 costimulation in t cells |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
VAV1
- 
- 