Summary

Name CBFB
Full Name Core-binding factor subunit beta
Synonyms CBF-beta, Polyomavirus enhancer-binding protein 2 beta subunit, PEA2-beta, PEBP2-beta, SL3-3 enhancer factor 1 subunit beta, SL3/AKV core-binding factor beta subunit |
Primary ID Q13951
Links - -
Type protein
Relations 7
Pathways HaematopoiesisTranscriptionalControl
Function Forms the heterodimeric complex core-binding factor (CBF) with RUNX family proteins (RUNX1, RUNX2, and RUNX3). RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'-TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX. The heterodimers bind to the core site of a number of enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers, LCK, IL3 and GM-CSF promoters. CBF complexes repress ZBTB7B transcription factor during cytotoxic (CD8+) T cell development. They bind to RUNX-binding sequence within the ZBTB7B locus acting as transcriptional silencer and allowing for cytotoxic T cell differentiation.

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Relations

Regulator Mechanism target score
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation CBFB 0.2
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation CBFB 0.2
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation CBFB 0.489
Publications: 1 Organism: Mus Musculus
Pathways:HaematopoiesisTranscriptionalControl
+ form complex img/form-complex.png binding Core Binding Factor complex 0.838
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by stabilization img/direct-activation.png binding RUNX1 0.838
Publications: 2 Organism: Mus Musculus
Pathways:HaematopoiesisTranscriptionalControl
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation CBFB 0.2
Publications: 1 Organism: Homo Sapiens