| + |
AML1-ETO | down-regulates activity 
binding
|
Core Binding Factor complex |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-256100 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 15829516 |
Two classes of models can describe how AML1-ETO could interfere with normal AML1 activity. First, because AML1-ETO has the potential to interact with AML1 co-factors (such as CBFβ) through its RD, it could act as a dominant-negative molecule by competing with AML1 for these co-factors. Although AML1-ETO has been shown to interact with CBFβ and repress the expression of AML1-regulated genes in vitro and in cell culture, the available data do not distinguish between these two models. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | AML1-ETO in AML |
| + |
CBFbeta-MYH11 | down-regulates activity 
relocalization
|
Core Binding Factor complex |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255741 |
|
|
Homo sapiens |
JURKAT Cell |
| pmid |
sentence |
| 9632809 |
The polyomavirus enhancer binding protein 2 (PEBP2)/core binding factor (CBF) is a transcription factor composed of two subunits, α and β. The gene encoding the β subunit is disrupted by inv(16), resulting in the formation of a chimeric protein, β-SMMHC, which is associated with acute myelogenous leukemia.Thus, the result suggess that β-SMMHC inhibits PEBP2-mediated transcription via cytoplasmic sequestration of the α subunit. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
Core Binding Factor complex | up-regulates quantity by expression 
methylation
|
SPI1 |
0.53 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255875 |
|
|
Mus musculus |
416B Cell |
| pmid |
sentence |
| 22012064 |
Furthermore, we show that both MLL and AML1/CBFβ are required for maintaining the H3K4-me3 mark at the PU.1 upstream regulatory element (URE) and promoter region, and for full PU.1 gene expression. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| Pathways: | AML1-ETO in AML |
| + |
MLL-AF4 | down-regulates quantity by repression
transcriptional regulation
|
Core Binding Factor complex |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255972 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 24449215 |
However, the functional consequence of MLL fusions on RUNX1/CBFβ activity has not been fully understood. In this report, we show that MLL fusion proteins and the N-terminal MLL portion of MLL fusions downregulate RUNX1 and CBFβ protein expression via the MLL CXXC domain and flanking regions. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
RUNX1 | form complex 
binding
|
Core Binding Factor complex |
0.841 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255710 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 12495904 |
The core binding factor (CBF) transcription complex, consisting of the interacting proteins RUNX1 and CBFβ, is essential for normal hematopoiesis |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
MLL-ENL | down-regulates quantity by repression
transcriptional regulation
|
Core Binding Factor complex |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255971 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 24449215 |
However, the functional consequence of MLL fusions on RUNX1/CBFβ activity has not been fully understood. In this report, we show that MLL fusion proteins and the N-terminal MLL portion of MLL fusions downregulate RUNX1 and CBFβ protein expression via the MLL CXXC domain and flanking regions. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
Core Binding Factor complex | up-regulates 
|
Differentiation |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255740 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 19813271 |
The core binding factor (CBF), consisting of a Runx protein and the CBFβ protein, is a transcription factor complex that is essential for emergence of the hematopoietic stem cell (HSC) from an endothelial cell stage. The hematopoietic defects observed in either Runx1 or CBFβ knockout mice underscore the necessity of this complex for definitive hematopoiesis. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| Pathways: | AML1-ETO in AML |
| + |
CBFB | form complex
binding
|
Core Binding Factor complex |
0.841 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255711 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 12495904 |
The core binding factor (CBF) transcription complex, consisting of the interacting proteins RUNX1 and CBFβ, is essential for normal hematopoiesis |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
MLL-AF9 | down-regulates quantity by repression
transcriptional regulation
|
Core Binding Factor complex |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255970 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 24449215 |
However, the functional consequence of MLL fusions on RUNX1/CBFβ activity has not been fully understood. In this report, we show that MLL fusion proteins and the N-terminal MLL portion of MLL fusions downregulate RUNX1 and CBFβ protein expression via the MLL CXXC domain and flanking regions. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
Core Binding Factor complex