Relation Results

Summary

Name RASGRF1
Full Name Ras-specific guanine nucleotide-releasing factor 1
Synonyms Ras-GRF1, Guanine nucleotide-releasing protein, GNRP, Ras-specific nucleotide exchange factor CDC25 | CDC25, GNRP, GRF1
Primary ID Q13972
Links - -
Type protein
Relations 2
Function Promotes the exchange of Ras-bound GDP by GTP.

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Type: Score: Layout: SPV 
0.40.516CHEK2RASGRF1PRKACA

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▶Modifications Tables

Relations
Regulator
Mechanism
target
score ℹ
+ CHEK2down-regulates img/direct_inhibition.png phosphorylation RASGRF1 0.4
Identifier Residue Sequence Organism Cell Line
SIGNOR-150843 Ser287 PITHDDVsSIFLNSE Homo sapiens
pmid sentence
During interphase, cdc25 is inhibited by ser287 phosphorylation (xenopus cdc25;ser 216 in human cdc25c) and this inhibitory phosphorylation is maintained by dna-responsive checkpoints / s287 is targeted by many kinases, including chk1, chk2, ctak-1, pka, p38 and mapkap kinase-2 suggesting that phosphorylation of this site may integrate multiple signaling inputs.
Publications: 1 Organism: Homo Sapiens
+ PRKACAup-regulates img/direct-activation.png phosphorylation RASGRF1 0.516
Identifier Residue Sequence Organism Cell Line
SIGNOR-73202 Ser927 KEKYRRMsLASAGFP Homo sapiens Neuron
pmid sentence
Phosphorylation of serine 916 of ras-grf1 contributes to the activation of exchange factor activity by muscarinic receptors.
Publications: 1 Organism: Homo Sapiens
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