Relation Results

Summary

Name BAZ1B
Full Name Tyrosine-protein kinase BAZ1B
Synonyms Bromodomain adjacent to zinc finger domain protein 1B, Williams syndrome transcription factor, Williams-Beuren syndrome chromosomal region 10 protein, Williams-Beuren syndrome chromosomal region 9 protein, hWALp2 | WBSC10, WBSCR10, WBSCR9, WSTF
Primary ID Q9UIG0
Links - -
Type protein
Relations 7
Function Atypical tyrosine-protein kinase that plays a central role in chromatin remodeling and acts as a transcription regulator. Involved in DNA damage respo ...
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Type: Score: Layout: SPV 
0.20.20.20.20.9230.3690.553MAPK14BAZ1BMAPK3MAPK9H2AXWICHMDC1B-WICH complex

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▶Modifications Tables

Relations
Regulator
Mechanism
target
score ℹ
+ MAPK14up-regulates img/direct-activation.png phosphorylation BAZ1B 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-188160 Ser158 KSDGACDsPSSDKEN Homo sapiens
pmid sentence
Moreover, this region (wac domain) was also phosphorylated by recombinant proteins of p38_? And jnk2_? But not by akt1
Publications: 1 Organism: Homo Sapiens
+ MAPK3up-regulates img/direct-activation.png phosphorylation BAZ1B 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-188164 Ser158 KSDGACDsPSSDKEN Homo sapiens
pmid sentence
Wstf, a specific component of two chromatin remodeling complexes (swi/snf-type winac and iswi-type wich), was phosphorylated by the stimulation of mapk cascades in vitro and in vivo. Ser-158 residue in the wac (wstf/acf1/cbpq46) domain, located close to the n terminus of wstf, was identified as a major phosphorylation target
Publications: 1 Organism: Homo Sapiens
+ MAPK9up-regulates img/direct-activation.png phosphorylation BAZ1B 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-188168 Ser158 KSDGACDsPSSDKEN Homo sapiens
pmid sentence
Wstf, a specific component of two chromatin remodeling complexes (swi/snf-type winac and iswi-type wich), was phosphorylated by the stimulation of mapk cascades in vitro and in vivo. Ser-158 residue in the wac (wstf/acf1/cbpq46) domain, located close to the n terminus of wstf, was identified as a major phosphorylation target
Publications: 1 Organism: Homo Sapiens
+ BAZ1Bup-regulates img/direct-activation.png phosphorylation H2AX 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-182831 Tyr143 ATQASQEy Homo sapiens
pmid sentence
We show that wstf phosphorylates tyr 142 of h2a.x, and that wstf activity has an important role in regulating several events that are critical for the dna damage response
Publications: 1 Organism: Homo Sapiens
+ BAZ1Bform complex img/form-complex.png binding WICH 0.923
Identifier Residue Sequence Organism Cell Line
SIGNOR-268828 Homo sapiens
pmid sentence
We show here that the WICH complex (WSTF-SNF2h) interacts with several nuclear proteins as follows: Sf3b155/SAP155, RNA helicase II/Gualpha, Myb-binding protein 1a, CSB, the proto-oncogene Dek, and nuclear myosin 1 in a large 3-MDa assembly, B-WICH, during active transcription. Our results show that a WSTF-SNF2h assembly is involved in RNA polymerase III transcription, and we suggest that WSTF-SNF2h-NM1 forms a platform in transcription while providing chromatin remodeling.
Publications: 1 Organism: Homo Sapiens
+ BAZ1Bdown-regulates img/indirect_inhibition.png MDC1 0.369
Identifier Residue Sequence Organism Cell Line
SIGNOR-168831 Homo sapiens
pmid sentence
H2ax tyr142 is constitutively phosphorylated by the kinase wstf, a member of the baz/wal family of chromatin remodelling enzymes, and blocks mdc1 recruitment
Publications: 1 Organism: Homo Sapiens
+ BAZ1Bform complex img/form-complex.png binding B-WICH complex 0.553
Identifier Residue Sequence Organism Cell Line
SIGNOR-268826 Homo sapiens
pmid sentence
The B-WICH complex is an extended form of WICH [26], and is involved in both RNA pol I and RNA pol III transcription [20], [21]. In addition to the three core proteins, WSTF, SNF2h, and nuclear myosin (NM1); the myb binding protein 1b, RNA helicase II/DXX21, and SAP155 all also associate via RNA species [21]. The subunit SNF2h is an ISWI ATPase, which slides nucleosomes in an ATP-dependent manner [27]. WSTF is a component of several complexes: two SNF2h complexes, B-WICH [21] and WICH [26], and one SWI/SNF type of chromatin remodelling complex, the WINAC complex, which is involved in vitamin D-mediated RNA pol II transcription
Publications: 1 Organism: Homo Sapiens
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