3.0
Summary
| Name |  BAZ1BView Modifications |
| Full Name | Tyrosine-protein kinase BAZ1B |
| Synonyms | Bromodomain adjacent to zinc finger domain protein 1B, Williams syndrome transcription factor, Williams-Beuren syndrome chromosomal region 10 protein, Williams-Beuren syndrome chromosomal region 9 protein, hWALp2 | WBSC10, WBSCR10, WBSCR9, WSTF |
| Primary ID | Q9UIG0 |
| Links |  -  -  |
| Type | protein |
| Relations | 7 |
| Function | Atypical tyrosine-protein kinase that plays a central role in chromatin remodeling and acts as a transcription regulator. Involved in DNA damage response by phosphorylating 'Tyr-142' of histone H2AX (H2AXY142ph). H2AXY142ph plays a central role in DNA repair and acts as a mark that distinguishes between apoptotic and repair responses to genotoxic stress. Essential component of the WICH complex, a chromatin remodeling complex that mobilizes nucleosomes and reconfigures irregular chromatin to a regular nucleosomal array structure. The WICH complex regulates the transcription of various genes, has a role in RNA polymerase I and RNA polymerase III transcription, mediates the histone H2AX phosphorylation at 'Tyr-142', and is involved in the maintenance of chromatin structures during DNA replication processes. In the complex, it mediates the recruitment of the WICH complex to replication foci during DNA replication. |
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Modifications Tables
Relations
| Regulator | Mechanism | target | score ℹ | |
|---|---|---|---|---|
| + | MAPK3 | up-regulates 
phosphorylation
|
BAZ1B | 0.2 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | MAPK14 | up-regulates
phosphorylation
|
BAZ1B | 0.2 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | MAPK9 | up-regulates
phosphorylation
|
BAZ1B | 0.2 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | BAZ1B | up-regulates
phosphorylation
|
H2AX | 0.2 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | BAZ1B | down-regulates 
|
MDC1 | 0.371 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | BAZ1B | form complex 
binding
|
B-WICH complex | 0.553 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | BAZ1B | form complex
binding
|
WICH | 0.923 |
| Publications: | 1 | Organism: | Homo Sapiens | |