4.0
Summary
| Name |  LPIN1View Modifications |
| Full Name | Phosphatidate phosphatase LPIN1 |
| Synonyms | Lipin-1 | KIAA0188 |
| Primary ID | Q14693 |
| Links |  -  -  |
| Type | protein |
| Relations | 5 |
| Function | Acts as a magnesium-dependent phosphatidate phosphatase enzyme which catalyzes the conversion of phosphatidic acid to diacylglycerol during triglyceride, phosphatidylcholine and phosphatidylethanolamine biosynthesis and therefore controls the metabolism of fatty acids at different levels (PubMed:20231281). Acts also as nuclear transcriptional coactivator for PPARGC1A/PPARA regulatory pathway to modulate lipid metabolism gene expression. Is involved in adipocyte differentiation. Isoform 1 is recruited at the mitochondrion outer membrane and is involved in mitochondrial fission by converting phosphatidic acid to diacylglycerol (By similarity). |
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Modifications Tables
Relations
| Regulator | Mechanism | target | score ℹ | |
|---|---|---|---|---|
| + | CTDNEP1 | up-regulates activity 
dephosphorylation
|
LPIN1 | 0.781 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | SRC | up-regulates activity
phosphorylation
|
LPIN1 | 0.2 |
| Publications: | 3 | Organism: | Homo Sapiens | |
| + | CHKA | down-regulates activity 
phosphorylation
|
LPIN1 | 0.273 |
| Publications: | 1 | Organism: | Homo Sapiens | |