3.0
Summary
| Name |  MTF1View Modifications |
| Full Name | Metal regulatory transcription factor 1 |
| Synonyms | MRE-binding transcription factor, Transcription factor MTF-1 | |
| Primary ID | Q14872 |
| Links |  -  -  |
| Type | protein |
| Relations | 5 |
| Function | Zinc-dependent transcriptional regulator of cellular adaption to conditions of exposure to heavy metals (PubMed:8065932). Binds to metal responsive elements (MRE) in promoters and activates the transcription of metallothionein genes like metallothionein-2/MT2A (PubMed:8065932). Also regulates the expression of metalloproteases in response to intracellular zinc and functions as a catabolic regulator of cartilages (By similarity). |
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Modifications Tables
Relations
| Regulator | Mechanism | target | score ℹ | |
|---|---|---|---|---|
| + | LATS2 | down-regulates activity 
phosphorylation
|
MTF1 | 0.2 |
| Publications: | 1 | |||
| + | LATS1 | down-regulates activity
phosphorylation
|
MTF1 | 0.2 |
| Publications: | 1 | |||
| + | MTF1 | up-regulates quantity by expression 
transcriptional regulation
|
MCAT | 0.2 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | MTF1 | up-regulates quantity by expression
transcriptional regulation
|
SOD1 | 0.292 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | MTF1 | up-regulates quantity by expression
transcriptional regulation
|
GCLC | 0.293 |
| Publications: | 1 | Organism: | Homo Sapiens | |