3.0
Summary
| Name |  PDIA6
|
| Full Name | Protein disulfide-isomerase A6 |
| Synonyms | Endoplasmic reticulum protein 5, ER protein 5, ERp5, Protein disulfide isomerase P5, Thioredoxin domain-containing protein 7 | ERP5, P5, TXNDC7 |
| Primary ID | Q15084 |
| Links |  -  -  |
| Type | protein |
| Relations | 3 |
| Function | May function as a chaperone that inhibits aggregation of misfolded proteins (PubMed:12204115). Negatively regulates the unfolded protein response (UPR) through binding to UPR sensors such as ERN1, which in turn inactivates ERN1 signaling (PubMed:24508390). May also regulate the UPR via the EIF2AK3 UPR sensor (PubMed:24508390). Plays a role in platelet aggregation and activation by agonists such as convulxin, collagen and thrombin (PubMed:15466936). |
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