4.0
Summary
| Name |  EIF2AK3View Modifications |
| Full Name | Eukaryotic translation initiation factor 2-alpha kinase 3 |
| Synonyms | PRKR-like endoplasmic reticulum kinase, Pancreatic eIF2-alpha kinase, HsPEK | PEK, PERK |
| Primary ID | Q9NZJ5 |
| Links |  -  -  |
| Type | protein |
| Relations | 18 |
| Pathways | COVID-19 Causal Network, SARS-CoV ER STRESS, Unfolded Protein Response |
| Function | Metabolic-stress sensing protein kinase that phosphorylates the alpha subunit of eukaryotic translation initiation factor 2 (EIF2S1/eIF-2-alpha) in response to various stress conditions. Key activator of the integrated stress response (ISR) required for adaptation to various stress, such as unfolded protein response (UPR) and low amino acid availability. EIF2S1/eIF-2-alpha phosphorylation in response to stress converts EIF2S1/eIF-2-alpha in a global protein synthesis inhibitor, leading to a global attenuation of cap-dependent translation, while concomitantly initiating the preferential translation of ISR-specific mRNAs, such as the transcriptional activator ATF4, and hence allowing ATF4-mediated reprogramming. Serves as a critical effector of unfolded protein response (UPR)-induced G1 growth arrest due to the loss of cyclin-D1 (CCND1). Involved in control of mitochondrial morphology and function. |
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Modifications Tables
Relations
| Regulator | Mechanism | target | score ℹ | |
|---|---|---|---|---|
| + | EIF2AK3 | down-regulates activity 
phosphorylation
|
EIF2S1 | 0.767 |
| Publications: | 3 | Organism: | Homo Sapiens | |
| Pathways: | COVID-19 Causal Network, SARS-CoV ER STRESS | |||
| + | EIF2AK3 | down-regulates
phosphorylation
|
EIF2S1 | 0.767 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| Pathways: | COVID-19 Causal Network, SARS-CoV ER STRESS | |||
| + | EIF2AK3 | up-regulates activity 
phosphorylation
|
DLG4 | 0.271 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | JAK1 | up-regulates activity
phosphorylation
|
EIF2AK3 | 0.2 |
| Publications: | 2 | Organism: | Mus Musculus | |
| Pathways: | COVID-19 Causal Network | |||
| + | EIF2AK3 | up-regulates
phosphorylation
|
EIF2AK3 | 0.2 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| Pathways: | COVID-19 Causal Network, SARS-CoV ER STRESS | |||
| + | EIF2AK3 | up-regulates activity
phosphorylation
|
OGT | 0.2 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | SOD1 | up-regulates activity
binding
|
EIF2AK3 | 0.277 |
| Publications: | 1 | Organism: | Mus Musculus | |
| + | EIF2AK3 | down-regulates activity
phosphorylation
|
PPP3CA | 0.2 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | PDIA6 | down-regulates activity
|
EIF2AK3 | 0.2 |
| Publications: | 1 | Organism: | Rattus Norvegicus | |
| + | PTPN1 | down-regulates activity
dephosphorylation
|
EIF2AK3 | 0.27 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | RHEB | down-regulates activity
binding
|
EIF2AK3 | 0.2 |
| Publications: | 1 | Organism: | In Vitro | |
| + | EIF2AK3 | up-regulates quantity
transcriptional regulation
|
PPP1R15A | 0.499 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| Pathways: | COVID-19 Causal Network, SARS-CoV ER STRESS | |||
| + | HSPA5 | down-regulates activity
binding
|
EIF2AK3 | 0.729 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| Pathways: | COVID-19 Causal Network, SARS-CoV ER STRESS | |||
| + | DNAJC3 | down-regulates activity
binding
|
EIF2AK3 | 0.615 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | S | up-regulates activity 
|
EIF2AK3 | 0.2 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| Pathways: | COVID-19 Causal Network, SARS-CoV ER STRESS | |||