| + |
TEAD | up-regulates quantity by expression 
transcriptional regulation
|
CNTF |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-278034 |
|
|
Homo sapiens |
Pancreatic Cancer Cell |
| pmid |
sentence |
| 31296870 |
In this model, treatment with LIF, but not IL-6, significantly elevated YAP/TAZ-TEAD transcriptional activity and sequentially increased expression of YAP1-targeted genes, CNTF and ANKRD at mRNA, in human PDAC cells |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
TEAD | up-regulates quantity by expression
transcriptional regulation
|
ANKRD1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-278035 |
|
|
Homo sapiens |
Pancreatic Cancer Cell |
| pmid |
sentence |
| 31296870 |
In this model, treatment with LIF, but not IL-6, significantly elevated YAP/TAZ-TEAD transcriptional activity and sequentially increased expression of YAP1-targeted genes, CNTF and ANKRD at mRNA, in human PDAC cells |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
TEAD | up-regulates activity
binding
|
AP1 |
0.358 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-277658 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 26258633 |
YAP/TAZ/TEAD and AP-1 form a complex that synergistically activates target genes directly involved in the control of S-phase entry and mitosis. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
YAP1 | up-regulates activity
binding
|
TEAD |
0.94 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-230719 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 23431053 |
YAP/TAZ do not contain intrinsic DNA-binding domains but instead bind to the promoters of target genes by interacting with DNA-binding transcription factors. YAP/TAZ mainly bind to the transcription factors TEAD1–4 to regulate genes involved in cell proliferation and cell death |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Hippo in cancer, Hippo Signaling, Integrin Signaling |
| + |
WWTR1 | up-regulates activity
binding
|
TEAD |
0.895 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-230722 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 23431053 |
YAP/TAZ do not contain intrinsic DNA-binding domains but instead bind to the promoters of target genes by interacting with DNA-binding transcription factors. YAP/TAZ mainly bind to the transcription factors TEAD1–4 to regulate genes involved in cell proliferation and cell death |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Hippo in cancer, Hippo Signaling, Integrin Signaling |
| + |
YAP/TAZ | up-regulates activity
binding
|
TEAD |
0.94 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-277635 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 23431053 |
YAP/TAZ do not contain intrinsic DNA-binding domains but instead bind to the promoters of target genes by interacting with DNA-binding transcription factors. YAP/TAZ mainly bind to the transcription factors TEAD1–4 to regulate genes involved in cell proliferation and cell death |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
TEAD